Patents by Inventor Ralf Altmeyer

Ralf Altmeyer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Composition and combined medication method for treating enterovirus infection
    Patent number: 10864210
    Abstract: The present invention provides a composition and a combined medication method for treating an enterovirus infection. In particular, the present invention provides a composition for inhibiting enteroviruses, wherein the composition at least contains an inhibitor of a 3D virus protein and an inhibitor of a capsid protein, or a combination of an inhibitor of a 3C protein and an inhibitor of a 3A protein.
    Type: Grant
    Filed: January 11, 2017
    Date of Patent: December 15, 2020
    Assignee: INSTITUT PASTEUR OF SHANGHAI, CHINESE ACADEMY OF SCIENCES
    Inventors: Gang Zou, Ralf Altmeyer, Yizhuo Wang
  • COMPOSITION AND COMBINED MEDICATION METHOD FOR TREATING ENTEROVIRUS INFECTION
    Publication number: 20190030027
    Abstract: The present invention provides a composition and a combined medication method for treating an enterovirus infection. In particular, the present invention provides a composition for inhibiting enteroviruses, wherein the composition at least contains an inhibitor of a 3D virus protein and an inhibitor of a capsid protein, or a combination of an inhibitor of a 3C protein and an inhibitor of a 3A protein.
    Type: Application
    Filed: January 11, 2017
    Publication date: January 31, 2019
    Inventors: Gang ZOU, Ralf ALTMEYER, Yizhuo WANG
  • Compound for treating respiratory syncytial virus infection and preparation method and use thereof
    Patent number: 10035816
    Abstract: The present invention declares a kind of compound to treat respiratory syncytial virus infection and its preparation method and application. The compound stated is cyclopamine's chemical analogs, has the property of inhibiting respiratory syncytial virus replication, and does not have the property of inhibiting Hedgehog signaling pathways. The preparation method stated is to get the cyclopamine's chemical analogs through drug chemical synthesis, then to screen the analogs with two parallel in vitro experiment. The compound described can be used to treat respiratory virus infection, paramyxovirus, respiratory syncytial virus infection, capillary bronchitis/pneumonia/tympanitis caused by respiratory syncytial virus. Furthermore, the compound described never cause the side effects of fetal malformation, and it overcame the teratogenicity of cyclopamine, and filled the gap of anti-human respiratory syncytial virus drug, especially of the field of pediatric drug.
    Type: Grant
    Filed: December 7, 2017
    Date of Patent: July 31, 2018
    Assignee: SHANDONG UNIVERSITY
    Inventors: Ralf Altmeyer, Jingjing Cao
  • COMPOUND FOR TREATING RESPIRATORY SYNCYTIAL VIRUS INFECTION AND PREPARATION METHOD AND USE THEREOF
    Publication number: 20180094021
    Abstract: The present invention declares a kind of compound to treat respiratory syncytial virus infection and its preparation method and application. The compound stated is cyclopamine's chemical analogs, has the property of inhibiting respiratory syncytial virus replication, and does not have the property of inhibiting Hedgehog signaling pathways. The preparation method stated is to get the cyclopamine's chemical analogs through drug chemical synthesis, then to screen the analogs with two parallel in vitro experiment. The compound described can be used to treat respiratory virus infection, paramyxovirus, respiratory syncytial virus infection, capillary bronchitis/pneumonia/tympanitis caused by respiratory syncytial virus. Furthermore, the compound described never cause the side effects of fetal malformation, and it overcame the teratogenicity of cyclopamine, and filled the gap of anti-human respiratory syncytial virus drug, especially of the field of pediatric drug.
    Type: Application
    Filed: December 7, 2017
    Publication date: April 5, 2018
    Applicant: SHANDONG UNIVERSITY
    Inventors: Ralf ALTMEYER, Jingjing Cao
  • Compositions, Methods, and Kits for Treating Influenza Viral Infections
    Publication number: 20110201665
    Abstract: The present invention provides compositions, methods, and kits for treating or preventing a viral infection (e.g., an infection caused by an influenza virus).
    Type: Application
    Filed: August 12, 2010
    Publication date: August 18, 2011
    Applicants: COMBINATORX (SINGAPORE) PTE. LTD., EXCRX (Singapore) PTE. LTD. (F.K.A. CombinatoRx (Singapore) PTE. LTD.
    Inventors: Ralf Altmeyer, Geeta Sharma, Vishal Vikas Pendharkar, Danilal Champalal Sharma
  • Compositions, Methods, and Kits for Treating Influenza Viral Infections
    Publication number: 20110028510
    Abstract: The present invention provides compositions, methods, and kits for treating or preventing a viral infection (e.g., an infection caused by an influenza virus).
    Type: Application
    Filed: February 18, 2010
    Publication date: February 3, 2011
    Applicants: COMBINATORX (SINGAPORE) PTE. LTD., EXCRX (Singapore) PTE. LTD. (F.K.A. CombinatoRx (Singapore) PTE. LTD.
    Inventors: Ralf Altmeyer, Geeta Sharma, Danilal Champalal Sharma, Vishal Vikas Pendharkar
  • COMPOSITIONS AND METHODS FOR TREATING VIRAL INFECTIONS
    Publication number: 20100081713
    Abstract: The present invention provides compositions, methods, and kits for treating or preventing a viral infection (e.g., an infection caused by an influenza virus).
    Type: Application
    Filed: March 18, 2009
    Publication date: April 1, 2010
    Inventors: Geeta Sharma, Ralf Altmeyer, Vishal Pendharker, Yu Chen, Michael Foley
  • COMPOSITIONS AND METHODS FOR TREATMENT OF VIRAL DISEASES
    Publication number: 20100009970
    Abstract: The present invention features compositions, methods, and kits useful in the treatment of viral diseases. In certain embodiments, the viral disease is caused by a single stranded RNA virus, a flaviviridae virus, or a hepatic virus. In particular embodiments, the viral disease is viral hepatitis (e.g., hepatitis A, hepatitis B, hepatitis C, hepatitis D, hepatitis E) and the agent or combination of agents includes sertraline, a sertraline analog, UK-416244, or a UK-416244 analog. Also featured are screening methods for identification of novel compounds that may be used to treat a viral disease.
    Type: Application
    Filed: March 18, 2009
    Publication date: January 14, 2010
    Applicant: Combinatorx (Singapore) Pte. Ltd.
    Inventors: Lisa M. Johansen, Christopher M. Owens, Christina Mawhinney, Todd W. Chappell, Alexander T. Brown, Michael G. Frank, Michael A. Foley, Ralf Altmeyer, Yu Chen
  • Compositions and methods for treatment of viral diseases
    Publication number: 20080161324
    Abstract: The present invention features compositions, methods, and kits useful in the treatment of viral diseases. In certain embodiments, the viral disease is caused by a single stranded RNA virus, a flaviviridae virus, or a hepatic virus. In particular embodiments, the viral disease is viral hepatitis (e.g., hepatitis A, hepatitis B, hepatitis C, hepatitis D, hepatitis E). Also featured are screening methods for identification of novel compounds that may be used to treat a viral disease.
    Type: Application
    Filed: September 13, 2007
    Publication date: July 3, 2008
    Inventors: Lisa M. Johansen, Christopher M. Owens, Christina Mawhinney, Todd W. Chappell, Alexander T. Brown, Michael G. Frank, Ralf Altmeyer
  • Nucleic acids, polypeptides, methods of expression, and immunogenic compositions associated with SARS corona virus spike protein
    Publication number: 20070190065
    Abstract: Nucleic acid molecules, polypeptides, immunogenic compositions, vaccines, and methods of making and using the nucleotides and encoded polypeptides associated with the Spike protein of SARS Corona Virus (SARS CoV) are disclosed.
    Type: Application
    Filed: December 4, 2006
    Publication date: August 16, 2007
    Inventors: Ralf Altmeyer, Beatrice Nal-Rogier, Cheman Chan, Francois Kien, Yiu Kam, Yu Siu, Kong Tse, Isabelle Staropoli, Jean-Claude Manuguerra
  • Process for vaccinating eucaryotic hosts and for protecting against SARS-CoV infection
    Publication number: 20060093616
    Abstract: The present invention relates to a process for vaccinating humans and for protecting against SARS-CoV infection.
    Type: Application
    Filed: September 28, 2005
    Publication date: May 4, 2006
    Inventors: Ralf Altmeyer, Beatrice Nal-Rogier, Cheman Chan, Yiu Kam, Francois Kien, Lewis Siu, Jane Tse, Isabelle Staropoli, J. Manugurrea, Malik Peiris