Patents by Inventor Ralf Anderskewitz

Ralf Anderskewitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200138780
    Abstract: This invention relates to 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides of formula 1 and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.
    Type: Application
    Filed: December 19, 2019
    Publication date: May 7, 2020
    Inventors: Ralf ANDERSKEWITZ, Florian BINDER, Matthias GRAUERT, Marc GRUNDL, Peter Wilhelm HAEBEL, Thorsten OOST, Alexander PAUTSCH, Stefan PETERS, Viktor VINTONYAK
  • Publication number: 20190167636
    Abstract: This invention relates to 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides of formula 1 and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.
    Type: Application
    Filed: February 8, 2019
    Publication date: June 6, 2019
    Inventors: Ralf ANDERSKEWITZ, Florian BINDER, Matthias GRAUERT, Marc GRUNDL, Peter Wilhelm HAEBEL, Thorsten OOST, Alexander PAUTSCH, Stefan PETERS, Viktor VINTONYAK
  • Patent number: 10238633
    Abstract: This invention relates to 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides of formula 1 and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: March 26, 2019
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Ralf Anderskewitz, Florian Binder, Matthias Grauert, Marc Grundl, Peter Wilhelm Haebel, Thorsten Oost, Alexander Pautsch, Stefan Peters, Viktor Vintonyak
  • Publication number: 20170266160
    Abstract: This invention relates to 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides of formula 1 and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.
    Type: Application
    Filed: June 6, 2017
    Publication date: September 21, 2017
    Inventors: Ralf ANDERSKEWITZ, Florian BINDER, Matthias GRAUERT, Marc GRUNDL, Peter Wilhelm HAEBEL, Thorsten OOST, Alexander PAUTSCH, Stefan PETERS, Viktor VINTONYAK
  • Patent number: 9713606
    Abstract: This invention relates to 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides of formula 1 and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: July 25, 2017
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Ralf Anderskewitz, Florian Binder, Matthias Grauert, Marc Grundl, Peter Wilhelm Haebel, Thorsten Oost, Alexander Pautsch, Stefan Peters, Viktor Vintonyak
  • Patent number: 9657015
    Abstract: Substituted bicyclic dihydropyrimidinones of formula 1 which are inhibitors of neutrophil elastase activity and useful as medicaments for the treatment of, inter alia, COPD.
    Type: Grant
    Filed: July 27, 2015
    Date of Patent: May 23, 2017
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Christian Gnamm, Ralf Anderskewitz, Holger Hoesch, Gerd Morschhaeuser, Thorsten Oost, Stefan Peters, Uwe Joerg Ries
  • Patent number: 9475779
    Abstract: Substituted bicyclic dihydropyrimidinones of formula 1 which are inhibitors of neutrophil elastase and useful as medicaments for the treatment of, inter alia, COPD.
    Type: Grant
    Filed: July 27, 2015
    Date of Patent: October 25, 2016
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Thorsten Oost, Ralf Anderskewitz, Christian Gnamm, Holger Hoesch, Gerd Morschhaeuser, Stefan Peters, Uwe Joerg Ries
  • Patent number: 9458113
    Abstract: Substituted dihydropyrimidinones of formula 1 which are neutrophil elastase inhibitors and useful as medicaments for the treatment of, inter alia, COPD.
    Type: Grant
    Filed: July 27, 2015
    Date of Patent: October 4, 2016
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Stefan Peters, Ralf Anderskewitz, Christian Gnamm, Holger Hoesch, Gerd Morschhaeuser, Thorsten Oost, Uwe Joerg Ries
  • Patent number: 9440930
    Abstract: Substituted bicyclic dihydropyrimidinones of formula 1 and their use as inhibitors of neutrophil elastase activity.
    Type: Grant
    Filed: July 27, 2015
    Date of Patent: September 13, 2016
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Thorsten Oost, Ralf Anderskewitz, Christian Gnamm, Gerd Morschhaeuser, Stefan Peters, Uwe Joerg Ries
  • Patent number: 9440960
    Abstract: This invention relates to a compound of formula I and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: September 13, 2016
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Matthias Grauert, Ralf Anderskewitz, Achim Bixenmann, Marc Grundl, Peter Wilhelm Haebel, Alexander Pautsch
  • Publication number: 20160081982
    Abstract: This invention relates to 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides of formula 1 and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.
    Type: Application
    Filed: December 1, 2015
    Publication date: March 24, 2016
    Inventors: Ralf ANDERSKEWITZ, Florian BINDER, Matthias GRAUERT, Marc GRUNDL, Peter Wilhelm HAEBEL, Thorsten OOST, Alexander PAUTSCH, Stefan PETERS, Viktor VINTONYAK
  • Patent number: 9290457
    Abstract: Substituted dihydropyrimidinones of formula 1 which are inhibitors of neutrophil elastase activity and which are useful as medicaments for the treatment of, inter alia, COPD.
    Type: Grant
    Filed: July 27, 2015
    Date of Patent: March 22, 2016
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Stefan Peters, Ralf Anderskewitz, Gerd Morschhaeuser, Thorsten Oost
  • Publication number: 20160039812
    Abstract: Substituted bicyclic dihydropyrimidinones of formula 1 which are inhibitors of neutrophil elastase activity and useful as medicaments for the treatment of, inter alia, COPD.
    Type: Application
    Filed: July 27, 2015
    Publication date: February 11, 2016
    Inventors: Christian GNAMM, Ralf ANDERSKEWITZ, Holger HOESCH, Gerd MORSCHHAEUSER, Thorsten OOST, Stefan PETERS, Uwe Joerg RIES
  • Publication number: 20160031831
    Abstract: Substituted bicyclic dihydropyrimidinones of formula 1 and their use as inhibitors of neutrophil elastase activity.
    Type: Application
    Filed: July 27, 2015
    Publication date: February 4, 2016
    Inventors: Thorsten OOST, Ralf ANDERSKEWITZ, Christian GNAMM, Gerd MORSCHHAEUSER, Stefan PETERS, Uwe Joerg RIES
  • Publication number: 20160031825
    Abstract: Substituted dihydropyrimidinones of formula 1 which are inhibitors of neutrophil elastase activity and which are useful as medicaments for the treatment of, inter alia, COPD.
    Type: Application
    Filed: July 27, 2015
    Publication date: February 4, 2016
    Inventors: Stefan PETERS, Ralf ANDERSKEWITZ, Gerd MORSCHHAEUSER, Thorsten OOST
  • Publication number: 20160031861
    Abstract: This invention relates to a compound of formula I and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.
    Type: Application
    Filed: July 31, 2015
    Publication date: February 4, 2016
    Inventors: Matthias GRAUERT, Ralf ANDERSKEWITZ, Achim BIXENMANN, Marc GRUNDL, Peter Wilhelm HAEBEL, Alexander PAUTSCH
  • Publication number: 20160031829
    Abstract: Substituted bicyclic dihydropyrimidinones of formula 1 which are inhibitors of neutrophil elastase and useful as medicaments for the treatment of, inter alia, COPD.
    Type: Application
    Filed: July 27, 2015
    Publication date: February 4, 2016
    Inventors: Thorsten OOST, Ralf ANDERSKEWITZ, Christian GNAMM, Holger HOESCH, Gerd MORSCHHAEUSER, Stefan PETERS, Uwe Joerg RIES
  • Publication number: 20160031830
    Abstract: Substituted dihydropyrimidinones of formula 1 which are neutrophil elastase inhibitors and useful as medicaments for the treatment of, inter alia, COPD.
    Type: Application
    Filed: July 27, 2015
    Publication date: February 4, 2016
    Inventors: Stefan PETERS, Ralf ANDERSKEWITZ, Christian GNAMM, Holger HOESCH, Gerd MORSCHHAEUSER, Thorsten OOST, Uwe Joerg RIES
  • Patent number: 9206164
    Abstract: The present invention relates to pyrazole compounds of formula (I) and pharmaceutically acceptable salts thereof having CRTH2 antagonistic activity, wherein L, Y1, Y2, Y3, Y4, Y5, Z, R1, R2, R3 and n have one of the meanings as indicated in the specification and claims, to their use as medicaments, to pharmaceutical compositions containing said compounds and to pharmaceutical compositions containing said compounds in combination with one or more active substances.
    Type: Grant
    Filed: March 15, 2012
    Date of Patent: December 8, 2015
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Domnic Martyres, Ralf Anderskewitz, Christoph Hoenke, Jan Kriegl, Thorsten Oost, Wolfgang Rist, Peter Seither
  • Patent number: 9115142
    Abstract: Dihydrothienopyrimidinesulphoxides of formula 1 wherein X is SO or SO2, R1 is H or C1-6-alkyl, R2 is H or an organic group as disclosed herein, and R3 is an optionally substituted, mono- or bicyclic, unsaturated, partially saturated or saturated heterocycle or an optionally substituted, mono- or bicyclic heteroaryl, and the pharmacologically acceptable salts thereof, as well as pharmaceutical compositions which contain these compounds. These dihydrothienopyrimidinesulphoxides are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin or eyes, diseases of the peripheral or central nervous system, or cancers.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: August 25, 2015
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Pascale Pouzet, Ralf Anderskewitz, Horst Dollinger, Dennis Fiegen, Thomas Fox, Rolf Goeggel, Christoph Hoenke, Domnic Martyres, Peter Nickolaus, Klaus Klinder