Patents by Inventor Ralf Glatthar

Ralf Glatthar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF METABOTROPIC GLUTAMATE RECEPTORS
    Publication number: 20140187600
    Abstract: The invention concerns the use an mGluR modulator, e.g. an mGluR5 modulator, for the treatment, prevention or delay of progression of cognitive dysfunction.
    Type: Application
    Filed: March 7, 2014
    Publication date: July 3, 2014
    Inventors: Ralf GLATTHAR, Donald JOHNS, Daniel UMBRICHT
  • USE OF METABOTROPIC GLUTAMATE RECEPTORS
    Publication number: 20120309742
    Abstract: The invention concerns the use an mGluR modulator, e.g. an mGluR5 modulator, for the treatment, prevention or delay of progression of cognitive dysfunction.
    Type: Application
    Filed: August 8, 2012
    Publication date: December 6, 2012
    Inventors: Ralf GLATTHAR, Donald JOHNS, Daniel UMBRICHT
  • FUSED PYRIMIDINONE COMPOUNDS AS MGLUR LIGANDS
    Publication number: 20100137340
    Abstract: The invention relates to compounds of Formula (I) wherein the substituents are as defined in claim 1; to compositions comprising said compounds and to their use as pharmaceutical agents.
    Type: Application
    Filed: March 3, 2008
    Publication date: June 3, 2010
    Inventors: Ralf Glatthar, Samuel Hintermann, Ivan-Toma Vranesic
  • ACETYLENE DERIVATIVES
    Publication number: 20100099682
    Abstract: The invention provides compounds of formula (I) wherein R1 represents hydrogen or alkyl; R2 represents an unsubstituted or substituted heterocycle or R2 represents an unsubstituted or substituted aryl; R3 represents alkyl or halogen; X represents a single bond or an alkandiyl-group, optionally interrupted by one or more oxygen atoms or carbonyl groups or carbonyloxy groups in free base or acid addition salt form, processes for their preparation and their use as pharmaceuticals.
    Type: Application
    Filed: September 17, 2009
    Publication date: April 22, 2010
    Inventors: Ralf GLATTHAR, Thomas J. Troxler, Thomas Zoller, Joachim Nozulak
  • Acetylene derivatives
    Patent number: 7696379
    Abstract: The invention provides compounds of formula (I) wherein R1 represents hydrogen or alkyl; R2 represents an unsubstituted or substituted heterocycle or R2 represents an unsubstituted or substituted aryl; R3 represents alkyl or halogen; X represents a single bond or an alkandiyl-group, optionally interrupted by one or more oxygen atoms or carbonyl groups or carbonyloxy groups in free base or acid addition salt form, processes for their preparation and their use as pharmaceuticals.
    Type: Grant
    Filed: April 24, 2006
    Date of Patent: April 13, 2010
    Assignee: Novartis AG
    Inventors: Ralf Glatthar, Thomas J. Troxler, Thomas Zoller, Joachim Nozulak
  • Certain substituted spirocyclic lactams and use thereof as pharmaceuticals
    Patent number: 7655686
    Abstract: The present invention relates to novel 2-(6-oxo-1,7-diaza-spiro[4.4]non-7-yl)-propionamides of the formula wherein R1, R2, R3, R4, R5, R6, m and p are as defined in the specification, to their preparation, to their use as pharmaceuticals and to pharmaceutical compositions containing them.
    Type: Grant
    Filed: June 26, 2007
    Date of Patent: February 2, 2010
    Assignee: Novartis AG
    Inventors: Yves Auberson, Ralf Glatthar, Rhys Salter, Oliver Simic, Marina Tintelnot-Blomley
  • Macrocyclic Lactams and Pharmaceutical Use Thereof
    Publication number: 20100022500
    Abstract: The present invention relates to novel macrocyclic compounds of the formula wherein R1, R2, R3, U, V, W, X, Y, Z and n are as defined in the specification, the number of ring atoms included in the macrocyclic ring being 14, 15, 16 or 17, in free base form or in acid addition salt form, to their preparation, to their use as pharmaceuticals and to pharmaceutical compositions comprising them.
    Type: Application
    Filed: September 25, 2009
    Publication date: January 28, 2010
    Inventors: Yves AUBERSON, Claudia Betschart, Ralf Glatthar, Kurt Laumen, Rainer MacHauer, Marina Tintelnot-Blomley, Thomas J. Troxler, Siem Jacob Veenstra
  • NOVEL BI-ARYL AMINES
    Publication number: 20090286827
    Abstract: The present invention relates to novel bi-aryl amines of formula (I) and to pharmaceutically acceptable prodrugs, salts, solvates, hydrates, and N-oxides thereof and to pharmaceutical compositions comprising them, methods of their use, and methods of their preparation.
    Type: Application
    Filed: April 2, 2007
    Publication date: November 19, 2009
    Inventors: Ralf Glatthar, David Carcache, Carsten Spanka, Ivan-toma Vranesic, Thomas J. Troxler
  • Macrocyclic lactams and pharmaceutical use thereof
    Patent number: 7612055
    Abstract: The present invention relates to novel macrocyclic compounds of the formula wherein R1, R2, R3, U, V, W, X, Y, Z and n are as defined in the specification, the number of ring atoms included in the macrocyclic ring being 14, 15, 16 or 17, in free base form or in acid addition salt form, to their preparation, to their use as pharmaceuticals and to pharmaceutical compositions comprising them.
    Type: Grant
    Filed: November 4, 2004
    Date of Patent: November 3, 2009
    Assignee: Novartis AG
    Inventors: Yves Auberson, Claudia Betschart, Ralf Glatthar, Kurt Laumen, Rainer Machauer, Marina Tintelnot-Blomley, Thomas J. Troxler, Siem Jacob Veenstra
  • Dibenzo[b,f]oxepine-10-carboxamides and pharmaceutical uses thereof
    Patent number: 7612054
    Abstract: The present invention pertains to novel dibenzo[b,f]oxepine-10-carboxamides compound to a process for the preparation of such compounds of formula I, their use as a pharmaceuticals, especially in the treatment of neurological and vascular disorders related to beta-amyloid generation and/or aggregation, and to pharmaceutical compositions and combinations comprising such compounds of formula I.
    Type: Grant
    Filed: July 23, 2004
    Date of Patent: November 3, 2009
    Assignee: Novartis AG
    Inventors: Yves Auberson, Claudia Betschart, Stefanie Flohr, Ralf Glatthar, Oliver Simic, Marina Tintelnot-Blomley, Thomas J. Troxler, Eric Vangrevelinghe, Siem Jacob Veenstra
  • Organic compounds
    Publication number: 20090105266
    Abstract: The present invention relates to novel benzimidazole derivatives, their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them, wherein the compounds have the formula (I): in which the substitutents are as defined in claim 1 and salts, solvates, hydrates and N-oxides thereof.
    Type: Application
    Filed: April 18, 2008
    Publication date: April 23, 2009
    Inventors: Ralf Glatthar, David Carcache
  • Organic Compounds
    Publication number: 20090005363
    Abstract: The present invention relates to novel nicotinic acid derivatives, of formula (I) wherein the substituents are defined in the specification, their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them.
    Type: Application
    Filed: December 18, 2006
    Publication date: January 1, 2009
    Inventors: Ralf Glatthar, David Orain, Carsten Spanka
  • Pyrrolidine and Piperidine Acetylene Derivatives for Use as Mglur5 Antagonists
    Publication number: 20080269250
    Abstract: The invention provides compounds of formula (I) wherein the substituents are as defined in the description, processes and intermediates for their preparation and their use as pharmaceuticals.
    Type: Application
    Filed: February 20, 2006
    Publication date: October 30, 2008
    Inventors: Ralf Glatthar, Thomas J. Troxler, Thomas Zoller, Joachim Nozulak
  • Acetylene Derivatives
    Publication number: 20080214673
    Abstract: The invention provides compounds of formula (I) wherein R1 represents hydrogen or alkyl; R2 represents an unsubstituted or substituted heterocycle or R2 represents an unsubstituted or substituted aryl; R3 represents alkyl or halogen; X represents a single bond or an alkandiyl-group, optionally interrupted by one or more oxygen atoms or carbonyl groups or carbonyloxy groups in free base or acid addition salt form, processes for their preparation and their use as pharmaceuticals.
    Type: Application
    Filed: April 24, 2006
    Publication date: September 4, 2008
    Inventors: Ralf Glatthar, Thomas J. Troxler, Thomas Zoller, Joachim Nozulak
  • Acetylene Derivatives
    Publication number: 20080194551
    Abstract: The invention provides compounds of formula (I), wherein the substituents are as defined in the specification, to processes for their preparation and their use as pharmaceuticals.
    Type: Application
    Filed: April 24, 2006
    Publication date: August 14, 2008
    Inventors: Ralf Glatthar, Thomas J. Troxler
  • Acetylene Derivatives
    Publication number: 20080188490
    Abstract: The invention provides compounds of formula (I) wherein the substituents are as defined in the specification, to processes for their preparation and corresponding intermediates, and their use as pharmaceuticals.
    Type: Application
    Filed: April 24, 2006
    Publication date: August 7, 2008
    Inventors: Ralf Glatthar, Thomas J. Troxler
  • Certain substituted spirocyclic lactams and use thereof as pharmaceuticals
    Publication number: 20070265328
    Abstract: The present invention relates to novel 2-(6-oxo-1,7-diaza-spiro[4.4]non-7-yl)-propionamides of the formula wherein R1, R2, R3, R4, R5, R6, m and p are as defined in the specification, to their preparation, to their use as pharmaceuticals and to pharmaceutical compositions containing them.
    Type: Application
    Filed: June 26, 2007
    Publication date: November 15, 2007
    Inventors: Yves Auberson, Ralf Glatthar, Rhys Salter, Oliver Simic, Marina Tintelnot-Blomley
  • Novel dibenzo [b, f] oxepine-10-carboxamides and pharmaceutical uses thereof
    Publication number: 20070111991
    Abstract: The present invention pertains to novel dibenzo[b,f]oxepine-10-carboxamides compound to a process for the preparation of such compounds of formula I, their use as a pharmaceuticals, especially in the treatment of neurological and vascular disorders related to beta-amyloid generation and/or aggregation, and to pharmaceutical compositions and combinations comprising such compounds of formula I.
    Type: Application
    Filed: July 23, 2004
    Publication date: May 17, 2007
    Inventors: Yves Auberson, Claudia Betschart, Stefanie Flohr, Ralf Glatthar, Oliver Simic, Marina Tintelnot-Blomley, Thomas Troxler, Eric Vangrevelinghe, Siem Veenstra
  • Macrocyclic lactams and pharmaceutical use thereof
    Publication number: 20070072792
    Abstract: The present invention relates to novel macrocyclic compounds of the formula wherein R1, R2, R3, U, V, W, X, Y, Z and n are as defined in the specification, the number of ring atoms included in the macrocyclic ring being 14, 15, 16 or 17, in free base form or in acid addition salt form, to their preparation, to their use as pharmaceuticals and to pharmaceutical compositions comprising them.
    Type: Application
    Filed: November 4, 2004
    Publication date: March 29, 2007
    Inventors: Yves Auberson, Claudia Betschart, Ralf Glatthar, Kurt Laumen, Rainer Machauer, Marina Tintelnot-Blomley, Thomas Troxler, Siem Veenstra
  • Certain substituted spirocyclic lactams and use thereof as pharmaceuticals
    Publication number: 20070015781
    Abstract: The present invention relates to novel 2-(6-oxo-1,7-diaza-spiro[4.4]non-7-yl)-propionamides of the formula wherein R1, R2, R3, R4, R5, R6, m and p are as defined in the specification, to their preparation, to their use as pharmaceuticals and to pharmaceutical compositions containing them.
    Type: Application
    Filed: October 4, 2004
    Publication date: January 18, 2007
    Inventors: Yves Auberson, Ralf Glatthar, Rhys Salter, Oliver Simic, Marina Tintelnot-Blomley