Abstract: The present invention relates to a device and a method for normalising nucleic acid concentrations, preferably for normalising nucleic acid concentrations in enzymatic nucleic acid amplification and modification methods.

Abstract: The present invention relates to a method for enriching nucleic acids with a length of not more than 300 nucleotides The invention also relates to a kit for enriching nucleic acids with a length of not more than 300 nucleotides, to the use of such a kit, to the use of an anion exchange matrix and to a method for treating a disease.

Abstract: The present in invention relates to a method for the separation of living cells from a mixture of dead and living cells which optionally can also possibly contain cell fragments.

Abstract: The present invention relates to an improved method for isolating nucleic acids, particularly genomic desoxyribonucleic acid (DNA) from blood.

Abstract: The present invention provides copolymers that facilitate nucleic acid analysis, compositions that comprise such copolymers, and methods for making or using such copolymers.

Abstract: The invention generally provides a method for the sample preparation for a subsequent preparation, processing or analysis method of a sample containing an at least one species of nucleic acid and/or one species of protein, whereby the method comprises the following steps: A) providing a sample which contains at least one species of a nucleic acid and/or of a protein, B) contacting the sample with a fluid or solid composition to produce a fluid sample preparation, whereby the composition contains at least a nitrogenous compound, which is selected from the group consisting of a) polyamines, b) amino acids, and oligo- and polypeptides, c) nitrogenous heterocyclic compounds, including homo-older heteropolymeres, which comprise these nitrogenous compounds, d) amines of the type R1R2NR3, whereby R1, R2 and R3 are chosen independently from one another from the group consisting of H, C1-C5-alkyl groups and aryl groups, whereby R1, R2 and R3 are not H simultaneously, e) carboxylic acid amides, f) inorganic ammonium sa

Abstract: The invention relates to a rapid method for isolating nucleic acid from a nucleic acid source, wherein the nucleic acid source is lysed in the absence of a chaotropic salt and in the absence of an alcohol. The lysate is subsequently filtered through a porous matrix consisting of a material based on silica or of a silica coated material, which binds the nucleic acid in the absence of a chaotropic salt and in the absence of an alcohol. Finally, the nucleic acid is eluted from the porous matrix by an aqueous buffer solution. Furthermore, this invention relates to a test kit in order to isolate the nucleic acid.

Abstract: The present invention provides a method for isolating biopolymers, particularly nucleic acids, such as DNA or RNA or hybrid molecules of DNA and RNA, from an aqueous solution utilizing magnetic particles, particularly silica magnetic particles. The method of the present invention involves forming a complex of the magnetic particles and the biopolymer in a mixture of said particles and said aqueous solution, comprising a salt and an additive; separating the complex from the mixture by a magnetic force, and eluting the biopolymer from the complex, wherein advantageously no substantial clustering of said magnetic particles occurs during the performance of the method. In a preferred embodiment the method of the invention is performed as an automated process.

Abstract: The present invention relates to a method for separation of a mixture comprising an organic and an aqueous phase making use of a solid phase system. Still further the invention refers to a specific solid phase system, namely a spin column which can be used in order to carry out said method in an easy way. According to preferred embodiments the organic phase is phenol or phenol/chloroform.

Abstract: The invention provides titanium dioxide pigments for plastics resin compositions which are excellent in dispersibility, light resistance, and weather resistance and little cause surface imperfection. In particular, the invention provides a titanium dioxide pigment suitable for general-purpose plastics resin compositions which can attain excellent dispersion and lacing resistance even when blended in a high concentration; a titanium dioxide pigment suitable for engineering plastics resin compositions which can attain dispersion properties, silver streaking resistance, inhibition of reduction in molecular weight, and thermal discoloration resistance at high levels; a process for the production of the pigments; and resin compositions containing the pigments. A titanium dioxide pigment for plastics resin compositions, characterized in that each titanium dioxide particle has a dense hydrous silica coat covering its surface and an organic compound coat formed on the silica coat not through an interlayer.

Abstract: Novel vanadium(IV) oxide bis(dialkyldithiocarbamates) of the formula ##STR1## which R and R.sup.1 denote identical or different, branched or straight-chain, saturated or unsaturated alkyl radicals having 1-18 carbon atoms or cycloalkyl radicals having 4-7 carbon atoms, with the proviso that R.sup.1 is not identical to R when R is C.sub.1 -C.sub.4 -alkyl, cyclobutyl or cyclohexyl, are prepared by a process comprising reacting 2 mols of an alkali metal dialkyldithiocarbamate of the formula ##STR2## in which R and R.sup.1 are as defined above and Me represents sodium, potassium or ammonium, with 1 mol of vanadium(IV) oxide sulfate pentahydrate in methanol or water as a solvent. The novel vanadium dithiocarbamates can be used as additives for permanent gear lubricating oils or hydraulic fluids to prolong the life of such oils.

Abstract: Novel tungsten hexa(dialkyldithiocarbamates) of the general formula I ##STR1## in which R and R.sup.1 can be identical or different, branched or straight-chain, saturated or unsaturated alkyl radicals having 1-18 carbon atoms are prepared by a process in which 6 mols of an alkali metal dialkyldithiocarbamate of the general formula II ##STR2## in which R and R.sup.1 are as signified above and Me can be sodium, potassium or ammonium, are reacted with 1 mol of tungsten hexachloride in a solvent which is inert with respect to the reaction. The alkali metal chloride or ammonium chloride formed is separated off and the tungsten hexa(dialkyldithiocarbamate) is isolated. The tungsten hexa(dialkyldithiocarbamates) of the invention can be used as additives for prolonging the life of hydraulic oils or permanent gear lubrication oils.