Patents by Inventor Ralf Hoffman

Ralf Hoffman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ASSESSMENT OF CELLULAR SIGNALING PATHWAY ACTIVITY USING PROBABILISTIC MODELING OF TARGET GENE EXPRESSION
    Publication number: 20230105263
    Abstract: The present application mainly relates to specific methods for inferring activity of one or more cellular signaling pathway(s) in tissue of a medical subject based at least on the expression level(s) of one or more target gene(s) of the cellular signaling pathway(s) measured in an extracted sample of the tissue of the medical subject, an apparatus comprising a digital compressor configured to perform such methods and a non-transitory storage medium storing instructions that are executable by a digital processing device to perform such methods.
    Type: Application
    Filed: August 24, 2022
    Publication date: April 6, 2023
    Applicant: InnoSIGN B.V.
    Inventors: WILHELMUS FRANCISCUS JOHANNES VERHAEGH, ANJA VAN DE STOLPE, HENDRIK JAN VAN OOIJEN, KALYANA CHAKRAVARTHI DULLA, MARCIA ALVES DE INDA, RALF HOFFMAN
  • RISK SCORES BASED ON HUMAN PHOSPHODIESTERASE 4 D VARIANT 7 EXPRESSION
    Publication number: 20210277479
    Abstract: Methods are described for stratifying patient risk for patients with prostate cancer and for providing a treatment recommendation to a patient based on a phosphodiesterase 4D variant 7 (PDE4D7) risk score. A diagnostic kit and a computer program product for the analysis and determination of the PDE4D7 risk score are also described.
    Type: Application
    Filed: November 28, 2017
    Publication date: September 9, 2021
    Inventors: Ralf HOFFMAN, Dianne Arnoldina Margaretha Wilhelmina VAN STRIJP, Anne Godefrida Catharina VAN BRUSSEL, Janneke WROBEL, Johannes Baptist Adrianus Dionisius VAN ZON, Eveline Catharina Anna Clasina DEN BIEZEN, Márcia ALVES DE INDA
  • ANALYSIS OF PROTEOLYTIC PROCESSING BY MASS SPECTROMETRY
    Publication number: 20100075356
    Abstract: The present invention relates to the simultaneous analysis of samples for determining differential proteolytic processing based on isotopic labelling of N-terminal peptides, wherein the isotopic labelling is achieved by incorporation of 18O during enzymatic proteolysis.
    Type: Application
    Filed: October 22, 2007
    Publication date: March 25, 2010
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventor: Ralf Hoffman
  • Use of reactive amines for the preparation of polyurethane foams
    Publication number: 20020016376
    Abstract: The invention relates to a process for preparing polyurethane foams (PUR foams) which uses reactive amines of the formula 1
    Type: Application
    Filed: June 18, 2001
    Publication date: February 7, 2002
    Inventors: Oliver Eyrisch, Ralf Hoffman, Hans-Heinrich Schlons
  • Electromagnetic relay
    Patent number: 5864270
    Abstract: In the case of the relay, an insulating wall which has at least three insulating layers is formed between the magnet system and a live metal part, in that the insulating wall is formed from a wall base having at least one insulating gap, and in that the insulating layer is formed in the insulating gap by insulating material which is inserted in liquid form and is subsequently cured.
    Type: Grant
    Filed: September 19, 1997
    Date of Patent: January 26, 1999
    Assignee: Siemens Aktiengesellschaft
    Inventor: Ralf Hoffman