Patents by Inventor Ralf Hoffmann

Ralf Hoffmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11028171
    Abstract: The present invention relates to a bispecific antibody construct comprising a first human binding domain which binds to human CDH3 on the surface of a target cell and a second binding domain which binds to human CDS on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
    Type: Grant
    Filed: April 18, 2016
    Date of Patent: June 8, 2021
    Assignee: AMGEN RESEARCH (MUNICH) GMBH
    Inventors: Bertram Weiss, Ann-Lena Frisk, Ruprecht Zierz, Peter Kufer, Tobias Raum, Doris Rau, Jonas Anlahr, Ralf Lutterbüse, Lisa Nahrwold, Christoph Dahlhoff, Claudia Blümel, Patrick Hoffmann
  • Patent number: 11007533
    Abstract: A material-bed roller mill including two adjacently arranged rollers which are oriented in an axially parallel manner and which rotate in opposite directions and between which a roller gap is formed, a foundation, two roller mountings, in each of which a roller is rotatably mounted, each roller mounting being secured to the foundation in a pivotal manner; and a clamping device. The clamping device is arranged outside of the roller gap and connects the two roller mountings. Each roller mounting has two rockers which are designed as separate components and each of which is arranged at an end of a roller and can be deflected independently of the other.
    Type: Grant
    Filed: June 15, 2016
    Date of Patent: May 18, 2021
    Assignee: GEBR. PFEIFFER SE
    Inventors: Dirk Hoffmann, Ralf Frankenberger, Karl-Heinz Schütte, Hardy Lessmeister, Lukas Schmitt
  • Publication number: 20210134550
    Abstract: A modular switching contactor arrangement for use in a safety-oriented application, has two switching contactor modules that can be arranged in succession by means of a coupling module, the switching contactor modules and the coupling module merely having to be joined together by a user, without any external wiring, so as to be mechanically and electrically coupled to one another. In the mounted state, the switching contactor arrangement has a reduced construction width that is substantially delimited by the narrow faces of the switching contactor modules. In particular, the construction width can be 22.5 mm.
    Type: Application
    Filed: December 21, 2017
    Publication date: May 6, 2021
    Inventor: Ralf Hoffmann
  • Publication number: 20210119364
    Abstract: A female connector for a relay includes a housing, a contact wall, and a spring tongue. The contact wall is arranged in the housing, and has a first deformation with at least one first contact elevation. The spring tongue is arranged in the housing, facing the contact wall, and has a second deformation having a plurality of second contact elevations. A dip is formed between two successive second contact elevations, and the second contact elevations are arranged opposite the at least one first contact elevation. The second contact elevations are configured to press contact pins of different lengths against the at least one first contact elevation in sprung manner.
    Type: Application
    Filed: May 21, 2019
    Publication date: April 22, 2021
    Inventor: Ralf Hoffmann
  • Publication number: 20210074500
    Abstract: A relay for assembling in terminal blocks includes an electromagnetic drive arrangement including an armature, an armature bearing spring, and a yoke. The armature is at least partially spaced from the yoke, is movably mounted, and is reduces the distance between the yoke and the armature under an effect of an electromagnetic force. The armature bearing spring applies a spring force counteracting the electromagnetic force. The yoke interacts electromagnetically with the armature to apply the electromagnetic force. A contact spring has a first contact surface and a contact arm, and the contact arm is spaced from the first contact surface and comes into contact with the first contact surface via a pressure force acting to establish an electrical connection between the first contact surface and the contact arm. An insulating element electrically isolates the armature from the contact arm and actuates the contact arm to produce the pressure force.
    Type: Application
    Filed: April 10, 2019
    Publication date: March 11, 2021
    Inventor: Ralf Hoffmann
  • Publication number: 20210075132
    Abstract: A plug-in connection arrangement for arranging a relay includes a terminal block comprising a relay holder configured to hold a relay. The relay comprises a bottom wall, a side wall, and a contact plug which projects out of the bottom wall. The side wall is arranged perpendicular to the bottom wall and includes an offset section which contacts the bottom wall and projects out into the relay in a direction of a surface normal of the side wall. The relay holder includes a socket configured to hold the contact plug of the relay when the relay is inserted into the relay holder. The relay holder also includes an insulating wall which, when the relay is inserted into the relay holder, is aligned parallel to the side wall and projects beyond the bottom wall to form an angled insulation section for the contact plug along a surface of the insulating wall.
    Type: Application
    Filed: April 10, 2019
    Publication date: March 11, 2021
    Inventor: Ralf Hoffmann
  • Publication number: 20200381187
    Abstract: The present disclosure relates to an electromechanical switching device comprising switching contacts configured to close an electrical circuit, wherein the switching contacts have a first switching contact and a second switching contact, wherein the first switching contact and the second switching contact can be brought into contact in order to close the electrical circuit, wherein at least one of the switching contacts s formed from a plurality of closed bodies which are arranged against one another, and wherein hollow spaces for receiving liquid are arranged between the closed bodies.
    Type: Application
    Filed: March 22, 2018
    Publication date: December 3, 2020
    Inventors: Ralf Hoffmann, Thomas Gundlach
  • Publication number: 20200211747
    Abstract: A method for magnetizing at least two magnets having different magnetic coercivities, includes the steps of: a) simultaneously exposing the at least two magnets to a first substantially homogeneous magnetic field having a predeterminable first field strength and a first magnetic field direction for completely magnetizing the magnets in the first magnetic field direction; b) simultaneously exposing the magnets magnetized in step a) to a second substantially homogeneous magnetic field having a predeterminable second field strength and a second magnetic field direction opposite to the first magnetic field direction such that the at least two magnets are differently magnetized.
    Type: Application
    Filed: August 10, 2018
    Publication date: July 2, 2020
    Inventors: Jens Heinrich, Ralf Hoffmann, Christian Mueller
  • Patent number: 10541097
    Abstract: An electromechanical relay, which can be inserted into a modular terminal in an insertion direction, wherein the relay is arranged in a housing and has two toggle switches, each of which is connected to connecting elements. At least one of the connecting elements leads out of the housing at the side and extends perpendicular to the insertion direction in at least some segments.
    Type: Grant
    Filed: July 6, 2017
    Date of Patent: January 21, 2020
    Assignee: Phoenix Contact GmbH & Co. KG
    Inventor: Ralf Hoffmann
  • Publication number: 20190326086
    Abstract: Methods, systems, and devices for a switching contact arrangement for a relay are described. A switching contact arrangement may include a first contact carrier including a first contact plug and a first contact pole in a first switching plane, a second contact carrier including a second contact plug and a second contact pole in a second switching plane, and a contact spring arranged between the first switching plane and the second switching plane. The contact spring may include a third contact carrier, a third contact plug, a third contact pole facing the first contact pole of the first contact carrier, and a fourth contact pole facing the second contact pole of the second contact carrier. The contact carriers may be acted upon by electrical signals via the respective contact plugs.
    Type: Application
    Filed: April 23, 2019
    Publication date: October 24, 2019
    Inventor: Ralf Hoffmann
  • Patent number: 10450544
    Abstract: Methods of producing, propagating and multiplying viruses, methods of identifying the presence of a virus in a sample, specifically methods using Japanese eel cell cultures. Also provided are an isolated Japanese eel cell culture, optionally infected with a virus, vaccines comprising viruses grown according to the methods of the invention, and a kit for propagating viruses comprising the Japanese eel cell culture. The virus may be a fish virus such as nodavirus, Infectious Pancreatic Necrosis Virus (IPNV) and Salmon Pancreas Disease Virus (SPDV).
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: October 22, 2019
    Assignee: Benchmark Animal Health Limited
    Inventors: Lindsey Ann Toon, Ralf Hoffmann
  • Patent number: 10435437
    Abstract: This invention relates to modified antibiotic peptides, particularly for use in medicine. The invention further relates to composite and methods for destroying microorganisms, such as bacteria, viruses or fungi, and to methods for treating microbial infections. The object of the invention is to develop novel antibiotic peptides, particularly having enhanced antibiotic activity and an expanded spectrum of activity against other strains of bacteria, particularly gram-positive bacteria such as Staphylococcus aureus. According to the invention, the object is attained in a first aspect by a peptide according to claim 1.
    Type: Grant
    Filed: December 23, 2016
    Date of Patent: October 8, 2019
    Assignee: UNIVERSITAET LEIPZIG
    Inventors: Ralf Hoffmann, Daniel Knappe, Kai Hilpert, Ralf Mikut, Serge Ruden
  • Publication number: 20190304722
    Abstract: An electromechanical relay, which can be inserted into a modular terminal in an insertion direction, wherein the relay is arranged in a housing and has two toggle switches, each of which is connected to connecting elements. At least one of the connecting elements leads out of the housing at the side and extends perpendicular to the insertion direction in at least some segments.
    Type: Application
    Filed: July 6, 2017
    Publication date: October 3, 2019
    Inventor: Ralf Hoffmann
  • Publication number: 20190304712
    Abstract: The disclosure relates to an electromagnetic switch, comprising: an armature; a slider configured to manually move to actuate the armature; and a deformable force transfer element positioned between the slider and the armature, wherein the slider is configured to be pressed against the deformable force transfer element to actuate the armature with a press force, and wherein the deformable force transfer element is configured to deform when a press force threshold value is exceeded to limit a transferable force from the slider onto the armature.
    Type: Application
    Filed: May 23, 2017
    Publication date: October 3, 2019
    Inventor: Ralf Hoffmann
  • Patent number: 10324431
    Abstract: The disclosure relates to a method for monitoring an electromechanical component of an automation system. The method may include acquiring of a mechanical state variable of the electromechanical component, acquiring of an electrical state variable of the electromechanical component, and determining of a state of the electromechanical component based on a multidimensional characteristic line field with a plurality of states of the electromechanical component, wherein the mechanical state variable and the electrical state variable are associated with each state of the electromechanical component.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: June 18, 2019
    Assignee: Phoenix Contact GmbH & Co. KG
    Inventors: Ralf Hoffmann, Jens Heinrich, Sebastian Heinrich, Christian Müller
  • Publication number: 20190040354
    Abstract: Methods of producing, propagating and multiplying viruses, methods of identifying the presence of a virus in a sample, specifically methods using Japanese eel cell cultures. Also provided are an isolated Japanese eel cell culture, optionally infected with a virus, vaccines comprising viruses grown according to the methods of the invention, and a kit for propagating viruses comprising the Japanese eel cell culture. The virus may be a fish virus such as nodavirus, Infectious Pancreatic Necrosis Virus (IPNV) and Salmon Pancreas Disease Virus (SPDV).
    Type: Application
    Filed: February 2, 2017
    Publication date: February 7, 2019
    Inventors: Lindsey Ann TOON, Ralf HOFFMANN
  • Publication number: 20180164759
    Abstract: The disclosure relates to a method for monitoring an electromechanical component of an automation system. The method may include acquiring of a mechanical state variable of the electromechanical component, acquiring of an electrical state variable of the electromechanical component, and determining of a state of the electromechanical component based on a multidimensional characteristic line field with a plurality of states of the electromechanical component, wherein the mechanical state variable and the electrical state variable are associated with each state of the electromechanical component.
    Type: Application
    Filed: December 11, 2017
    Publication date: June 14, 2018
    Inventors: Ralf Hoffmann, Jens Heinrich, Sebastian Heinrich, Christian Müller
  • Publication number: 20180148794
    Abstract: The present invention pertains to methods for determining gene expression signatures for diagnosing patients with prostate cancer, e.g., to establish a prognosis for such patients, for determining the predisposition of said patient to develop aggressive or indolent disease, for example after primary treatment, and/or for identification and stratification of patients for available therapies. The invention also relates to products used in such methods, e.g. kits, software, and the like. The present invention further relates to therapies for use in the treatment of patients that have been diagnosed, identified, or stratified in any of the methods dis closed herein.
    Type: Application
    Filed: May 26, 2016
    Publication date: May 31, 2018
    Inventors: RALF HOFFMANN, EVELINE DEN BIEZEN-TIMMERMANS, DIANNE ARNOLDINA MARGARETHA WILHELMINA VAN STRIJP, ANNE GODEFRIDA CATHARINA VAN BRUSSEL, MARCIA ALVES DE INDA, JANNEKE WROBEL
  • Publication number: 20180148795
    Abstract: The present invention relates to methods for diagnosing, monitoring or prognosticating prostate cancer or the progression state of prostate cancer wherein said method determines the state of the prostate cancer, based on the expression level of phosphodiesterase 4D (PDE4D) variants. The invention further relates to a method of identifying an individual for eligibility for prostate cancer therapy. The invention also relates to products for the analysis of phosphodiesterase 4D (PDE4D) variants as well as pharmaceutical compositions modulating the activity and/or expression of PDE4D variants.
    Type: Application
    Filed: May 26, 2016
    Publication date: May 31, 2018
    Inventors: RALF HOFFMANN, EVELINE DEN BIEZEN-TIMMERMANS, DIANNE ARNOLDINA MARGARETHA WILHELMINA VAN STRIJP, ANNE GODEFRIDA CATHARINA VAN BRUSSEL, MARCIA ALVES DE INDA, JANNEKE WROBEL, JOANNES BAPTIST ADRIANUS DIONISIUS VAN ZON
  • Patent number: 9856298
    Abstract: The invention relates to modified antibiotic peptides, in particular derivatives of apidaecin and oncocin, preferably having increased stability, reduced immunoreaction, and improved pharmacokinetics. In the invention, the peptide antibiotics are reversibly protected by means of a linker having the polymer polyethylene glycol (PEG). The peptide linker contains a recognition sequence for trypsin-like serum proteases. In the apidaecin derivatives, the linker and the PEG are bonded to a side chain. In the serum, the linker is cut by serum proteases and PEG is separated off. The released peptide still contains remnants of the linker, which are still bonded to the amino group in the side chain. Astonishingly, said remaining remnants of the linker impair the activity of the antimicrobial peptide only a little or not at all.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: January 2, 2018
    Assignee: UNIVERSITAET LEIPZIG
    Inventors: Ralf Hoffmann, Nicole Berthold, Friederike Nollmann