Patents by Inventor Ralf Jungmann

Ralf Jungmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HIGH-THROUGHPUT AND HIGHLY MULTIPLEXED IMAGING WITH PROGRAMMABLE NUCLEIC ACID PROBES
    Publication number: 20230027974
    Abstract: The present invention provides, inter alia, methods and compositions for imaging, at high spatial resolution, targets of interest.
    Type: Application
    Filed: July 8, 2022
    Publication date: January 26, 2023
    Applicant: President and Fellows of Harvard College
    Inventors: Peng Yin, Sarit Agasti, Xi Chen, Ralf Jungmann
  • Quantitative DNA-based imaging and super-resolution imaging
    Patent number: 11536715
    Abstract: The present disclosure provides, inter alia, methods and compositions (e.g., conjugates) for imaging, at high spatial resolution, targets of interest.
    Type: Grant
    Filed: September 3, 2019
    Date of Patent: December 27, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: Ralf Jungmann, Peng Yin, Mingjie Dai, Maier S. Avendano Amado, Johannes B. Woehrstein
  • Nucleic acid nanostructure barcode probes
    Patent number: 10876971
    Abstract: Provided herein are, inter alia, barcode probes comprised of transiently or stably fluorescently labeled nucleic acid nanostructures that are fully addressable and able to be read using standard fluorescent microscope and methods of use thereof including methods of use as detectable labels for probes.
    Type: Grant
    Filed: June 14, 2018
    Date of Patent: December 29, 2020
    Assignees: President and Fellows of Harvard College, Dana-Farber Cancer Institute, Inc.
    Inventors: Chenxiang Lin, Chao Li, William M. Shih, Peng Yin, Ralf Jungmann
  • Molecular identification with subnanometer localization accuracy
    Patent number: 10851411
    Abstract: The present invention relates to methods of determining the sequence of nucleotides in target nucleic acid molecules. Thus, the invention relates to methods of sub-unit sequencing. The methods comprise the use of identification nucleic acid detection entities which specifically hybridize to the target nucleic acid, bind identification tags and have localization tags transiently bind thereto.
    Type: Grant
    Filed: February 6, 2017
    Date of Patent: December 1, 2020
    Assignees: Ludwig-Maximilians-Universität München, XGenomes Corp.
    Inventors: Johannes B. Wöhrstein, Kalim Mir, Ralf Jungmann, Florian Schüder
  • QUANTITATIVE DNA-BASED IMAGING AND SUPER-RESOLUTION IMAGING
    Publication number: 20200064340
    Abstract: The present disclosure provides, inter alia, methods and compositions (e.g., conjugates) for imaging, at high spatial resolution, targets of interest.
    Type: Application
    Filed: September 3, 2019
    Publication date: February 27, 2020
    Applicant: President and Fellows of Harvard College
    Inventors: Ralf Jungmann, Peng Yin, Mingjie Dai, Maier S. Avendano Amado, Johannes B. Woehrstein
  • HIGH-THROUGHPUT AND HIGHLY MULTIPLEXED IMAGING WITH PROGRAMMABLE NUCLEIC ACID PROBES
    Publication number: 20190323061
    Abstract: The present invention provides, inter alia, methods and compositions for imaging, at high spatial resolution, targets of interest.
    Type: Application
    Filed: March 18, 2019
    Publication date: October 24, 2019
    Applicant: President and Fellows of Harvard College
    Inventors: Peng Yin, Sarit Agasti, Xi Chen, Ralf Jungmann
  • High-throughput and highly multiplexed imaging with programmable nucleic acid probes
    Patent number: 10294510
    Abstract: The present invention provides, inter alia, methods and compositions for imaging, at high spatial resolution, targets of interest.
    Type: Grant
    Filed: March 11, 2015
    Date of Patent: May 21, 2019
    Assignee: President and Fellows of Harvard College
    Inventors: Peng Yin, Sarit Agasti, Xi Chen, Ralf Jungmann
  • High-throughput and highly multiplexed imaging with programmable nucleic acid probes
    Patent number: 10190151
    Abstract: The present invention provides, inter alia, methods and compositions for imaging, at high spatial resolution, targets of interest.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: January 29, 2019
    Assignee: President and Fellows of Harvard College
    Inventors: Peng Yin, Sarit Agasti, Xi Chen, Ralf Jungmann
  • MOLECULAR IDENTIFICATION WITH SUBNANOMETER LOCALIZATION ACCURACY
    Publication number: 20190024165
    Abstract: The present invention relates to methods of determining the sequence of nucleotides in target nucleic acid molecules. Thus, the invention relates to methods of sub-unit sequencing. The methods comprise the use of identification nucleic acid detection entities which specifically hybridize to the target nucleic acid, bind identification tags and have localization tags transiently bind thereto.
    Type: Application
    Filed: February 6, 2017
    Publication date: January 24, 2019
    Inventors: Johannes B. WÖHRSTEIN, Kalim MIR, Ralf JUNGMANN, Florian SCHÜDER
  • NUCLEIC ACID NANOSTRUCTURE BARCODE PROBES
    Publication number: 20190003973
    Abstract: Provided herein are, inter alia, barcode probes comprised of transiently or stably fluorescently labeled nucleic acid nanostructures that are fully addressable and able to be read using standard fluorescent microscope and methods of use thereof including methods of use as detectable labels for probes.
    Type: Application
    Filed: June 14, 2018
    Publication date: January 3, 2019
    Applicants: President and Fellows of Harvard College, Dana-Farber Cancer Institute, Inc.
    Inventors: Chenxiang Lin, Chao Li, William M. Shih, Peng Yin, Ralf Jungmann
  • HIGH-THROUGHPUT AND HIGHLY MULTIPLEXED IMAGING WITH PROGRAMMABLE NUCLEIC ACID PROBES
    Publication number: 20180216159
    Abstract: The present invention provides, inter alia, methods and compositions for imaging, at high spatial resolution, targets of interest.
    Type: Application
    Filed: March 23, 2018
    Publication date: August 2, 2018
    Applicant: President and Fellows of Harvard College
    Inventors: Peng Yin, Sarit Agasti, Xi Chen, Ralf Jungmann
  • Nucleic acid nanostructure barcode probes
    Patent number: 10024796
    Abstract: Provided herein are, inter alia, barcode probes comprised of transiently or stably fluorescently labeled nucleic acid nanostructures that are fully addressable and able to be read using standard fluorescent microscope and methods of use thereof including methods of use as detectable labels for probes.
    Type: Grant
    Filed: October 28, 2011
    Date of Patent: July 17, 2018
    Assignees: President and Fellows of Harvard College, Dana-Farber Cancer Institute, Inc.
    Inventors: Chenxiang Lin, Chao Li, William M. Shih, Peng Yin, Ralf Jungmann
  • Compositions and methods relating to complex nucleic acid nanostructures
    Patent number: 9975916
    Abstract: The invention provides SST motifs of controlled size and shape, comprised of a plurality of oligonucleotides, and methods for their synthesis. The motifs are formed, at least in part, by the self-assembly of single stranded oligonucleotides into curved, corrugated or twisted structures. The location of each oligonucleotide in the resultant motif is known. Accordingly, the motifs may be modified with specificity.
    Type: Grant
    Filed: November 6, 2013
    Date of Patent: May 22, 2018
    Assignee: President and Fellows of Harvard College
    Inventors: Peng Yin, Diming Wei, Mingjie Dai, Cameron Myhrvold, Yonggang Ke, Ralf Jungmann
  • High-throughput and highly multiplexed imaging with programmable nucleic acid probes
    Patent number: 9944972
    Abstract: The present invention provides, inter alia, methods and compositions for imaging, at high spatial resolution, targets of interest.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: April 17, 2018
    Assignee: President and Fellows of Harvard College
    Inventors: Peng Yin, Sarit Agasti, Xi Chen, Ralf Jungmann
  • TRIGGERED ASSEMBLY OF METAFLUOROPHORES
    Publication number: 20170327888
    Abstract: Aspects of the present disclosure relate to systems, kits and methods that comprise a nucleic acid capture strand linked to a first dye molecule, a nucleic acid trigger strand longer than the capture strand and comprising (a) a capture domain that is complementary to the capture strand and (b) at least two concatenated domains, each of which comprises two subdomains, and a partially double-stranded nucleic acid comprising a single-stranded toehold domain having a nucleotide sequence complementary to one of the subdomains of the two subdomains of the concatenated domains, a double-stranded region linked to a second dye molecule and having a nucleotide sequence complementary to the other of the two subdomains of the concatenated domains, and a single-stranded hairpin loop having a nucleotide sequence that is complementary to the single-stranded toehold domain.
    Type: Application
    Filed: June 14, 2017
    Publication date: November 16, 2017
    Applicant: President and Fellows of Harvard College
    Inventors: Luvena L. Ong, David Yu Zhang, Diming Wei, Ralf Jungmann, Peng Yin
  • HIGH-THROUGHPUT AND HIGHLY MULTIPLEXED IMAGING WITH PROGRAMMABLE NUCLEIC ACID PROBES
    Publication number: 20170137864
    Abstract: The present invention provides, inter alia, methods and compositions for imaging, at high spatial resolution, targets of interest.
    Type: Application
    Filed: January 19, 2017
    Publication date: May 18, 2017
    Applicant: President and Fellows of Harvard College
    Inventors: Peng Yin, Sarit Agasti, Xi Chen, Ralf Jungmann
  • NUCLEIC ACID POLYHEDRA FROM SELF-ASSEMBLED VERTEX-CONTAINING FIXED-ANGLE NUCLEIC ACID STRUCTURES
    Publication number: 20170015698
    Abstract: Provided herein are compositions comprising nucleic acid structures comprising three or more arms arranged at fixed angles from each other, composites thereof such as DNA cages, and methods for their synthesis and use.
    Type: Application
    Filed: March 6, 2015
    Publication date: January 19, 2017
    Applicant: President and Fellows of Harvard College
    Inventors: Ryosuke Iinuma, Yonggang Ke, Ralf Jungmann, Peng Yin
  • HIGH-THROUGHPUT AND HIGHLY MULTIPLEXED IMAGING WITH PROGRAMMABLE NUCLEIC ACID PROBES
    Publication number: 20160319328
    Abstract: The present invention provides, inter alia, methods and compositions for imaging, at high spatial resolution, targets of interest.
    Type: Application
    Filed: March 11, 2015
    Publication date: November 3, 2016
    Applicant: President and Fellows of Harvard College
    Inventors: Peng Yin, Sarit Agasti, Xi Chen, Ralf Jungmann
  • QUANTITATIVE DNA-BASED IMAGING AND SUPER-RESOLUTION IMAGING
    Publication number: 20160161472
    Abstract: The present disclosure provides, inter alia, methods and compositions (e.g., conjugates) for imaging, at high spatial resolution, targets of interest.
    Type: Application
    Filed: July 30, 2014
    Publication date: June 9, 2016
    Applicant: President and Fellows of Harvard College
    Inventors: Ralf Jungmann, Peng Yin, Mingjie Dai, Maier S. Avendano Amado, Johannes B. Woehrstein
  • COMPOSITIONS AND METHODS RELATING TO COMPLEX NUCLEIC ACID NANOSTRUCTURES
    Publication number: 20150329584
    Abstract: The invention provides SST motifs of controlled size and shape, comprised of a plurality of oligonucleotides, and methods for their synthesis. The motifs are formed, at least in part, by the self-assembly of single stranded oligonucleotides into curved, corrugated or twisted structures. The location of each oligonucleotide in the resultant motif is known. Accordingly, the motifs may be modified with specificity.
    Type: Application
    Filed: November 6, 2013
    Publication date: November 19, 2015
    Applicant: President and Fellows of Harvard College
    Inventors: Peng Yin, Diming Wei, Mingjie Dai, Cameron Myhrvold, Yonggang Ke, Ralf Jungmann