Patents by Inventor Ralf Karch

Ralf Karch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8288558
    Abstract: The present invention relates to novel compounds of the formula 1, their preparation, intermediates for the preparation and the use of the compounds of the formula 1 as catalysts in various metathesis reactions. The novel metathesis catalysts, which are obtained from readily available precursors, have a high activity and can be used for any type of metathesis reaction.
    Type: Grant
    Filed: September 13, 2007
    Date of Patent: October 16, 2012
    Assignee: Umicore AG & Co. KG
    Inventors: Dieter Arlt, Michal Bieniek, Ralf Karch
  • Patent number: 8288534
    Abstract: The invention relates to a novel process for the preparation of Ruthenium metathesis catalysts of the formula Ruthenium metathesis catalysts have been widely applied in the synthesis of macrocyclic drug compounds.
    Type: Grant
    Filed: May 6, 2010
    Date of Patent: October 16, 2012
    Assignee: Roche Palo Alto LLC
    Inventors: Angelino Doppiu, Ralf Karch, Kurt Puentener, Andreas Rivas-Nass, Michelangelo Scalone, Roland Winde, Eileen Woerner
  • Publication number: 20120101279
    Abstract: The invention relates to a method for preparation of ruthenium-based carbene catalysts with a chelating alkylidene ligand (“Hoveyda-type catalysts”) by reacting a penta-coordinated ruthenium (II)-alkylidene complex of the type (L) (Py)X1X2Ru(alkylidene) with a suitable olefin derivative in a cross metathesis reaction. The method delivers high yields and is conducted preferably in aromatic hydrocarbon solvents. The use of phosphine-containing Ru carbene complexes as starting materials can be avoided. Catalyst products with high purity, particularly with low Cu content, can be obtained.
    Type: Application
    Filed: May 4, 2010
    Publication date: April 26, 2012
    Inventors: Roland Winde, Angelino Doppiu, Eileen Woerner, Andreas Rivas-Nass, Ralf Karch, Christian Slugovc, Christina Schinagl
  • Publication number: 20110190524
    Abstract: The present invention is directed to a method for the preparation of ruthenium indenylidene carbene catalysts of the type (L)(L?)X2Ru(II)(aryl-indenylidene). The method comprises the steps of reacting the precursor compound Ru(PPh3)nX2 (n=3-4) with a propargyl alcohol derivative in an cyclic diether solvent such as 1,4-dioxane at temperatures in the range of 80 to 130° C. and reaction times of 1 to 60 minutes. Optionally, additional neutral electron donor ligands such as PCy3, phobane ligands or NHC ligands are added to the reaction mixture for ligand exchange. The method includes a precipitation step for purification, after which the product is isolated. The ruthenium-indenylidene carbene catalysts are obtained in high purity and are used as catalysts for metathesis reactions (RCM, ROMP and CM) and as precursors for the synthesis of modified ruthenium carbene catalysts.
    Type: Application
    Filed: October 2, 2009
    Publication date: August 4, 2011
    Inventors: Roland Winde, Ralf Karch, Andreas Rivas-Nass, Angelino Doppiu, Gerhard Peter, Eileen Woerner
  • Publication number: 20110184203
    Abstract: The present invention relates to a single-stage process for preparing dienyl-ruthenium complexes of the formula Ru(+II)(dienyl)2, wherein an Ru(II) starting compound of the formula Ru(X)p(Y)q is reacted with a diene ligand in the presence of an inorganic and/or organic base in a single-stage process. Here, polar organic solvents, preferably mixtures of polar organic solvents with water, are used. The dienyl-ruthenium complexes prepared according to the invention are used as precursors for homo-geneous catalysts, for producing functional coatings and for therapeutic applications.
    Type: Application
    Filed: May 30, 2009
    Publication date: July 28, 2011
    Applicant: UMICORE AG & Co. KG
    Inventors: Angelino Doppiu, Andreas Rrivas-Nass, Ralf Karch, Roland Winde
  • Patent number: 7951969
    Abstract: The present invention relates to a process for the preparation of indium acetate comprising the steps: (a) reacting an indium compound with an alkaline compound in a protic solvent to obtain an iridium containing precipitate, where the reaction is conducted in the presence of at least one component (i) selected from oxalic acid, a salt of oxalic acid, formic acid and a salt of formic acid, (b) reacting the precipitate in the presence of at least (i) one compound selected from oxalic acid, a salt of oxalic acid, formic acid and a salt of formic acid, and (ii) CH3CO2H and/or CH3(CO)O(CO)CH3 to give an iridium acetate containing solution. The invention also relates to indium acetate having a low halide content, to an indium containing precipitate and to uses of the iridium containing precipitate of the present invention and the iridium acetate of the present invention.
    Type: Grant
    Filed: May 24, 2006
    Date of Patent: May 31, 2011
    Assignee: Umicore AG & Co. KG
    Inventors: Ralf Karch, Bernd Kayser, Andreas Rivas-Nass, Jürgen Bodo Widmer, Roland Winde, Eileen Wörner
  • Publication number: 20110112318
    Abstract: The invention relates to ruthenium complexes which have a chiral diphosphorus donor ligand and in which the ruthenium has the oxidation state (+11) and the chiral diphosphorus donor ligand has bidentate P—P coordination to the ruthenium. The ruthenium complexes are present in two forms (cationic type A and uncharged type B), are cyclic and have a four- to six-membered ring incorporating the diphosphorus donor ligand. The chiral diphosphorus donor ligands are selected from the group consisting of diphosphines, diphospholanes, diphosphites, diphosphonites and diazaphospholanes. Furthermore, processes for preparing the ruthenium complexes of types A and B, which are based on ligand exchange reactions, are described. The Ru complexes are used as catalysts for homogeneous asymmetric catalysis for preparing organic compounds.
    Type: Application
    Filed: March 26, 2009
    Publication date: May 12, 2011
    Applicant: Umicore AG & Co. KG
    Inventors: Andreas Rivas-Nass, Ralf Karch, Roland Winde, Angelino Doppiu, Tina Schneider
  • Publication number: 20110021798
    Abstract: The invention relates to ruthenium complexes with a chiral ferrocenyldiphosphine ligand, wherein the ruthenium has the oxidation state (+II) and the chiral ferrocenyldiphosphine ligand has bidentate P—P coordination to the ruthenium. The ruthenium complexes are cyclic and with the ferrocenyldiphosphine ligand have an at least eight-membered ring. The ferrocenyldiphosphine ligands are selected from the group consisting of Taniaphos, Taniaphos-OH and Walphos ligands. A process for preparing the Ru complexes is described. The Rn complexes are used as catalysts for homogeneous asymmetric catalysis for preparing organic compounds.
    Type: Application
    Filed: May 8, 2008
    Publication date: January 27, 2011
    Applicant: UMICORE AG & CO. KG
    Inventors: Albrecht Salzer, Angelino Doppiu, Nadine Langenscheidt, Andreas Rivas-Nass, Ralf Karch, Roland Winde, Stefanie Mayrhofer
  • Publication number: 20100286403
    Abstract: The invention relates to a novel process for the preparation of Ruthenium metathesis catalysts of the formula Ruthenium metathesis catalysts have been widely applied in the synthesis of macrocyclic drug compounds.
    Type: Application
    Filed: May 6, 2010
    Publication date: November 11, 2010
    Inventors: Angelino Doppiu, Ralf Karch, Kurt Puentener, Andreas Rivas-Nass, Michelangelo Scalone, Roland Winde, Eileen Woerner
  • Publication number: 20100234628
    Abstract: The present invention relates to a process for the preparation of indium acetate comprising the steps: (a) reacting an indium compound with an alkaline compound in a protic solvent to obtain an iridium containing precipitate, where the reaction is conducted in the presence of at least one component (i) selected from oxalic acid, a salt of oxalic acid, formic acid and a salt of formic acid, (b) reacting the precipitate in the presence of at least (i) one compound selected from oxalic acid, a salt of oxalic acid, formic acid and a salt of formic acid, and (ii) CH3CO2H and/or CH3(CO)O(CO)CH3 to give an iridium acetate containing solution. The invention also relates to indium acetate having a low halide content, to an indium containing precipitate and to uses of the iridium containing precipitate of the present invention and the iridium acetate of the present invention.
    Type: Application
    Filed: May 24, 2006
    Publication date: September 16, 2010
    Inventors: Ralf Karch, Bernd Kayser, Andreas Rivas-Nass, Jurgen Bodo Widmer, Roland Winde, Eileen Worner
  • Publication number: 20100113795
    Abstract: The present invention relates to novel compounds of the formula 1, their preparation, intermediates for the preparation and the use of the compounds of the formula 1 as catalysts in various metathesis reactions. The novel metathesis catalysts, which are obtained from readily available precursors, have a high activity and can be used for any type of metathesis reaction.
    Type: Application
    Filed: September 13, 2007
    Publication date: May 6, 2010
    Inventors: Dieter Arlt, Michal Bieniek, Ralf Karch
  • Patent number: 7615659
    Abstract: The present invention relates to a process for preparing a palladium(0) compound, comprising the reaction of a palladium compound with one or more compounds of the general formula I, II or III in the presence of a base: Term-O—{[Si(R16)(CR19CR17R18)O]v[Si(R20)2O]w}-Term ??(III). The Palladium(0) compounds are suitable as homogeneous catalysts, as a precursor for preparing homogeneous catalysts, as a precursor for preparing homogeneous catalysts in situ or as a precursor for preparing heterogeneous catalysts.
    Type: Grant
    Filed: October 30, 2003
    Date of Patent: November 10, 2009
    Assignee: Umicore AG & Co. KG
    Inventors: Bernd Kayser, Ralf Karch, Oliver Briel, Ingo Kleinwächter
  • Patent number: 7312349
    Abstract: Diene-bis-aquo-rhodium(I) complex of the general formula [Rh(diene)(H2O)2]X where diene is a cyclic diene and X is a noncoordinating anion.
    Type: Grant
    Filed: August 10, 2004
    Date of Patent: December 25, 2007
    Assignee: Umicore AG & Co. KG
    Inventors: Andreas Rivas-Nass, Gerhard Peter, Jürgen Widmer, Ralf Karch, Oliver Briel
  • Patent number: 7268233
    Abstract: The invention relates to novel monocarbene complexes of nickel, palladium or platinum with electron-deficient olefin ligands, to their preparation and to their use in the homogeneous catalysis of organic reactions.
    Type: Grant
    Filed: August 7, 2003
    Date of Patent: September 11, 2007
    Assignee: Umicore AG & Co. KG
    Inventors: Ralf Karch, Oliver Briel, Bernd Kayser, Matthias Beller, Kumaravel Selvakumar, Anja Frisch, Alexander Zapf
  • Publication number: 20070142654
    Abstract: Diene-bis-aquo-rhodium(I) complex of the general formula [Rh(diene)(H2O)2]X where diene is a cyclic diene and X is a noncoordinating anion.
    Type: Application
    Filed: August 10, 2004
    Publication date: June 21, 2007
    Inventors: Andreas Rivas-Nass, Gerhard Peter, Jurgen Widmer, Ralf Karch, Oliver Briel
  • Publication number: 20060122398
    Abstract: The invention relates to novel monocarbene complexes of nickel, palladium or platinum with electron-deficient olefin ligands, to their preparation and to their use in the homogeneous catalysis of organic reactions.
    Type: Application
    Filed: August 7, 2003
    Publication date: June 8, 2006
    Inventors: Ralf Karch, Oliver Briel, Bernd Kayser, Matthias Beller, Kumaravel Selvakumar, Anja Frisch, Alexander Zapf
  • Publication number: 20060106239
    Abstract: The present invention relates to a process for preparing a palladium(0) compound, comprising the reaction of a palladium compound with one or more compounds of the general formula I, II or III in the presence of a base: Term-O—{[Si(R16)(CR19CR17R18)O]v[Si(R20)2O]w}-Term ??(III). The Palladium(0) compounds are suitable as homogeneous catalysts, as a precursor for preparing homogeneous catalysts, as a precursor for preparing homogeneous catalysts in situ or as a precursor for preparing heterogeneous catalysts.
    Type: Application
    Filed: October 30, 2003
    Publication date: May 18, 2006
    Inventors: Bernd Kayser, Ralf Karch, Oliver Briel, Ingo Kleinwachter
  • Publication number: 20040166361
    Abstract: The present invention provides a surface coating of platinum in which the coating is formed from platinum in a black modification. This can be obtained by applying an organic platinum complex compound with platinum in the oxidation state 0 that decomposes thermally at temperatures below 200° C., or a coating composition which consists substantially of such a platinum complex compound, to the surface of a substrate and then thermally decomposing the platinum complex compound. The surface coatings can be used in many ways, for example as protective layers against mechanical and/or chemical and/or thermal effects, as antiadhesion layers, as antireflective layers or as catalytically active layers.
    Type: Application
    Filed: April 12, 2004
    Publication date: August 26, 2004
    Inventors: Michael Oechsle, Ralf Karch, Bernd Kayser
  • Patent number: 6686495
    Abstract: A process for the preparation of mono-, bi- or poly-functional biaryls in the presence of a metal complex of the general formula IV as catalyst.
    Type: Grant
    Filed: October 16, 2001
    Date of Patent: February 3, 2004
    Assignee: OMG AG & Co KG
    Inventors: Matthias Beller, Mario Gómez-Andreu, Alexander Zapf, Ralf Karch, Ingo Kleinwächter, Oliver Briel
  • Publication number: 20020107426
    Abstract: A process for the preparation of mono-, bi- or poly-functional biaryls in the presence of a metal complex of the general formula IV 1
    Type: Application
    Filed: October 16, 2001
    Publication date: August 8, 2002
    Inventors: Matthias Beller, Mario Gomez-Andreo, Alexander Zapf, Ralf Karch, Ingo Kleinwachter, Oliver Briel