Patents by Inventor Ralf Kellmann

Ralf Kellmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes to make neosaxitoxin and analogues thereof
    Patent number: 11566271
    Abstract: The present invention relates to processes to make neosaxitoxin, and analogues and variants thereof, and intermediates in the production of neosaxitoxin in recombinant host cells. Neosaxitoxin and the analogues and variants thereof may be used in the production of pharmaceutical compositions.
    Type: Grant
    Filed: October 19, 2020
    Date of Patent: January 31, 2023
    Assignees: Vestlandets Innovasjonsseiskap AS, Newsouth Innovations Pty Limited
    Inventors: Ralf Kellmann, Brett Neilan
  • PROCESS
    Publication number: 20210108239
    Abstract: The present invention relates to processes to make neosaxitoxin, and analogues and variants thereof, and intermediates in the production of neosaxitoxin in recombinant host cells. Neosaxitoxin and the analogues and variants thereof may be used in the production of pharmaceutical compositions.
    Type: Application
    Filed: October 19, 2020
    Publication date: April 15, 2021
    Inventors: Ralf Kellmann, Brett Neilan
  • Detection of saxitoxin-producing dinoflagellates
    Patent number: 10947601
    Abstract: The invention generally relates to the field of saxitoxins and the identification of microorganisms capable of producing them. More specifically, the invention relates to the identification of genes encoding saxitoxin in dinoflagellates, and methods for the specific detection of dinoflagellates that are producers of saxitoxins.
    Type: Grant
    Filed: December 6, 2016
    Date of Patent: March 16, 2021
    Assignees: EWSOUTH INNOVATIONS PTY LIMITED, UNIVERSITETET I OSLO
    Inventors: Brett A. Neilan, Shauna Ann Murray, Anke Stuken, Kjetill S. Jakobsen, Russel J. S. Orr, Ralf Kellmann
  • Process
    Patent number: 10920256
    Abstract: The present invention relates to processes to make neosaxitoxin, and analogues and variants thereof, and intermediates in the production of neosaxitoxin in recombinant host cells. Neosaxitoxin and the analogues and variants thereof may be used in the production of pharmaceutical compositions.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: February 16, 2021
    Assignees: Vestlandets Innovasjonsseiskap AS, NEWSOUTH INNOVATIONS PTY LIMITED
    Inventors: Ralf Kellmann, Brett Neilan
  • Cyanobacteria saxitoxin gene cluster and detection of cyanotoxic organisms
    Patent number: 10415097
    Abstract: The present invention provides methods for the detection of cyanobacteria, and in particular, methods for the detection of cyanotoxic organisms. The invention further relates to methods of screening for compounds that modulate the activity of polynucleotides and/or polypeptides of the saxitoxin biosynthetic pathways.
    Type: Grant
    Filed: November 16, 2015
    Date of Patent: September 17, 2019
    Assignee: Newsouth Innovations PTY Limited
    Inventors: Brett A. Neilan, Troco Kaan Mihali, Ralf Kellmann, Young Jae Jeon
  • PROCESS
    Publication number: 20190048375
    Abstract: The present invention relates to processes to make neosaxitoxin, and analogues and variants thereof, and intermediates in the production of neosaxitoxin in recombinant host cells. Neosaxitoxin and the analogues and variants thereof may be used in the production of pharmaceutical compositions.
    Type: Application
    Filed: February 10, 2017
    Publication date: February 14, 2019
    Applicants: Bergen Teknologioverføring AS, University of New South Wales Innovations, University of New South Wales Innovations
    Inventors: Ralf Kellmann, Brett Neilan
  • DETECTION OF SAXITOXIN-PRODUCING DINOFLAGELLATES
    Publication number: 20170081733
    Abstract: The invention generally relates to the field of saxitoxins and the identification of microorganisms capable of producing them. More specifically, the invention relates to the identification of genes encoding saxitoxin in dinoflagellates, and methods for the specific detection of dinoflagellates that are producers of saxitoxins.
    Type: Application
    Filed: December 6, 2016
    Publication date: March 23, 2017
    Inventors: Brett A. Neilan, Shauna Ann Murray, Anke Stuken, Kjetill S. Jakobsen, Russel J. S. Orr, Ralf Kellmann
  • Detection of saxitoxin-producing dinoflagellates
    Patent number: 9580759
    Abstract: The current disclosure generally relates to the field of saxitoxins and the identification of microorganisms capable of producing them. In particular, the saxitoxin A (sxtA) gene comprising catalytic domain sequences saxitoxin A1 (sxtA1) and saxitoxin A4 (sxtA4) is identified in a number of dinoflagellate species. The disclosure relates to methods of detection of saxitoxin-producing dinoflagellates by amplification and detection of the sxtA gene (in particular by PCR) and kits and primers for use in the method are also disclosed. Saxitoxin-producing dinoflagellate genera detected by the method include Alexandrium, Pyrodinium or Gymnodinium.
    Type: Grant
    Filed: May 16, 2012
    Date of Patent: February 28, 2017
    Assignees: UNIVERSITETET I OSLO, NEWSOUTH INNOVATIONS PTY LIMITED
    Inventors: Brett A. Neilan, Shauna Ann Murray, Anke Corinna Stüken, Kjetill S. Jakobsen, Russel J. S. Orr, Ralf Kellmann
  • CYANOBACTERIA SAXITOXIN GENE CLUSTER AND DETECTION OF CYANOTOXIC ORGANISMS
    Publication number: 20160153030
    Abstract: The present invention provides methods for the detection of cyanobacteria, and in particular, methods for the detection of cyanotoxic organisms. The invention further relates to methods of screening for compounds that modulate the activity of polynucleotides and/or polypeptides of the saxitoxin biosynthetic pathways.
    Type: Application
    Filed: November 16, 2015
    Publication date: June 2, 2016
    Inventors: Brett A. NEILAN, Troco Kaan MIHALI, Ralf KELLMANN, Young Jae JEON
  • DETECTION OF SAXITOXIN-PRODUCING DINOFLAGELLATES
    Publication number: 20140113301
    Abstract: The current disclosure generally relates to the field of saxitoxins and the identification of microorganisms capable of producing them. In particular, the saxitoxin A (sxtA) gene comprising catalytic domain sequences saxitoxin A1 (sxtA1) and saxitoxin A4 (sxtA4) is identified in a number of dinoflagellate species. The disclosure relates to methods of detection of saxitoxin-producing dinoflagellates by amplification and detection of the sxtA gene (in particular by PCR) and kits and primers for use in the method are also disclosed. Saxitoxin-producing dinoflagellate genera detected by the method include Alexandrium, Pyrodinium or Gymnodinium.
    Type: Application
    Filed: May 16, 2012
    Publication date: April 24, 2014
    Applicants: UNIVERSITETET I OSLO, NEWSOUTH INNOVATIONS PTY LIMITED
    Inventors: Brett A. Neilan, Shauna Ann Murray, Anke Stuken, Kjetill S. Jakobsen, Russel J. S. Orr, Ralf Kellmann
  • CYANOBACTERIA SAXITOXIN GENE CLUSTER AND DETECTION OF CYANOTOXIC ORGANISMS
    Publication number: 20110129842
    Abstract: The present invention relates to methods for the detection of cyanobacteria, dinoflagellates, and in particular, methods for the detection of cyanotoxic organisms. Kits for the detection of cyanobacteria, dinoflagellates, and cyanotoxic organisms are provided. The invention further relates to methods of screening for compounds that modulate the activity of polynucleotides and/or polypeptides of the saxitoxin and cylindrospermopsin biosynthetic pathways.
    Type: Application
    Filed: December 5, 2008
    Publication date: June 2, 2011
    Applicant: NEWSOUTH INNOVATIONS PTY LIMITED
    Inventors: Brett A. Neilan, Troco Kaan Mihali, Ralf Kellmann, Young Jae Jeon