Patents by Inventor Ralf Knierieme

Ralf Knierieme has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7981897
    Abstract: The present invention relates to a hitherto unknown crystal form B of (3-cyano-1H-indol-7-yl)-[4-(4-fluorophenethyl)-piperazin-1-yl]methanone, hydrochloride, to a process for the preparation thereof, and to the use thereof for the preparation of a medicament.
    Type: Grant
    Filed: September 8, 2005
    Date of Patent: July 19, 2011
    Assignee: Merck Patent GmbH
    Inventors: Andreas Bathe, Bernd Helfert, Ralf Knierieme, Christoph Saal, Ronald Keiner
  • Patent number: 7528256
    Abstract: The invention relates to a process for the preparation of nicotinaldehydes by reduction of the corresponding nicotinic acid morpholinamides.
    Type: Grant
    Filed: March 27, 2004
    Date of Patent: May 5, 2009
    Assignee: Merck Patent GmbH
    Inventors: Heinz-Hermann Bokel, Mike Brandner, Ludwig Gantzert, Ralf Knierieme
  • Publication number: 20070259885
    Abstract: The present invention relates to a hitherto unknown crystal form B of (3-cyano-1H-indol-7-yl)-[4-(4-fluorophenethyl)-piperazin-1-yl]methanone, hydrochloride, to a process for the preparation thereof, and to the use thereof for the preparation of a medicament
    Type: Application
    Filed: September 8, 2005
    Publication date: November 8, 2007
    Inventors: Andreas Bathe, Bernd Helfert, Ralf Knierieme, Christoph Saal, Ronald Keiner
  • Publication number: 20060199965
    Abstract: The invention relates to a process for the preparation of nicotinaldehydes by reduction of the corresponding nicotinic acid morpholinamides.
    Type: Application
    Filed: March 27, 2004
    Publication date: September 7, 2006
    Inventors: Heinz-Hermann Bokel, Mike Brandner, Ludwig Gantzert, Ralf Knierieme
  • Patent number: 7045629
    Abstract: The present invention relates to a process for the preparation of 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chroman, the enantiomers and its salts, characterised in that 5-(4-fluorophenyl)pyridine-3-carbaldehyde is reacted directly with aminomethylchroman or its salts under reducing conditions to give 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chroman, and the latter is, if desired, converted into one of its physiologically acceptable salts by treatment with an acid.
    Type: Grant
    Filed: April 8, 2002
    Date of Patent: May 16, 2006
    Assignee: Merck Patent GmbH
    Inventors: Heinz-Hermann Bokel, Steffen Neuenfeld, Ludwig Gantzert, Ralf Knierieme, Elke Simon, Ralf Devant, Udo Helm, Helmut Reubold
  • Publication number: 20040138266
    Abstract: The present invention relates to a process for the preparation of 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chroman, the enantiomers and its salts, characterised in that 5-(4-fluorophenyl)pyridine-3-carbaldehyde is reacted directly with aminomethylchroman or its salts under reducing conditions to give 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chroman, and the latter is, if desired, converted into one of its physiologically acceptable salts by treatment with an acid.
    Type: Application
    Filed: October 27, 2003
    Publication date: July 15, 2004
    Inventors: Heinz-Hermann Bokel, Steffen Neuenfeld, Ludwig Gantzert, Ralf Knierieme, Elke Simon, Ralf Devant, Udo Helm, Helmut Reubold