Patents by Inventor Ralf Krappa

Ralf Krappa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diagnostic and therapeutic use of steroidogenic acute regulatory protein for neurodegenerative diseases
    Publication number: 20070118913
    Abstract: The present invention discloses the differential expression of the steroidogenic acute regulatory protein (StAR) gene in specific brain regions of Alzheimer's disease patients. Based on this finding, this invention provides a method for diagnosing or prognosticating a neurodegenerative disease, in particular Alzheimer's disease, in a subject, or for determining whether a subject is at increased risk of developing such a disease. Furthermore, this invention provides therapeutic and prophylactic methods for treating or preventing Alzheimer's disease and related neurodegenerative disorders using the StAR gene and gene products. A method of screening for modulating agents of neurodegenerative diseases is also disclosed.
    Type: Application
    Filed: June 5, 2003
    Publication date: May 24, 2007
    Inventors: Thomas Hesterkamp, Heinz Von Der Kammer, Ralf Krappa, Johannes Pohlner
  • Diagnostic and therapeutic use of cyp11a1 for neurodegenerative diseases
    Publication number: 20060099585
    Abstract: The present invention discloses the differential expression of the CYP11A1 gene in specific brain regions of Alzheimer's disease patients. Based on this finding, this invention provides a method for diagnosing or prognosticating a neurodegenerative disease, in particular Alzheimer's disease in a subject, or for determining whether a subject is at increased risk of developing such a disease. Furthermore, this invention provides therapeutic and prophylactic methods for treating or preventing Alzheimer's disease and related neurodegenerative disorders using the CYP11A1 gene and gene products. A method of screening for modulating agents of neurodegenerative diseases is also disclosed.
    Type: Application
    Filed: May 28, 2003
    Publication date: May 11, 2006
    Applicant: EVOCTEC NEUROSCIENCES GMBH
    Inventors: Thomas Hesterkamp, Heinz Von Der Kammer, Ralf Krappa, Johannes Pohlner
  • Diagnostic and therapeutic use of an atp-binding cassette gene and protein for neurodegenerative diseases
    Publication number: 20050289657
    Abstract: The present invention discloses the differential expression of the ABCA1 gene in specific brain regions of Alzheimer's disease patients. Based on this finding, this invention provides a method for diagnosing or prognosticating a neurodegenerative disease, in particular Alzheimer's disease, in a subject, or for determining whether a subject is at increased risk of developing such a disease. Furthermore, this invention provides therapeutic and prophylactic methods for treating or preventing Alzheimer's disease and related neurodegenerative disorders using the ABCA1 gene and its corresponding gene products. A method of screening for modulating agents of neuro-degenerative diseases is also disclosed.
    Type: Application
    Filed: April 17, 2003
    Publication date: December 29, 2005
    Inventors: Thomas Hesterkamp, Heinz Von Der Kammer, Ralf Krappa, Johannes Pohlner
  • Diagnostic and therapeutic use of a caveolae-associated integral membrane protein for alzheimer's disease and related neurodegenerative disorders
    Publication number: 20040053265
    Abstract: The present invention discloses the differential expression of the caveolae-associated integral membrane protein flotillin-1 gene in specific brain regions of Alzheimer's disease patients. Based on this finding, this invention provides a method for diagnosing or prognosing Alzheimer's disease or other neurodegenerative diseases in a patient, or for determining whether a subject is at increased risk of developing Alzheimer's disease or other related neurodegenerative diseases. Furthermore, this invention provides therapeutic and prophylatic methods for treating or preventing Alzheimer's disease and related neurodegenerative disorders using a caveolae-associated integral membrane protein gene, in particular the flotillin-1 gene. A method of screening for modulating agents of neurodegenerative, diseases is also disclosed.
    Type: Application
    Filed: June 6, 2003
    Publication date: March 18, 2004
    Inventors: Rainer Hipfel, Heinz Von Der Kammer, Ralf Krappa, Johannes Pohlner
  • Evectins and their use
    Patent number: 6495674
    Abstract: The present invention relates generally to the field of neurobiology. More particularly, the invention relates to the discovery of a new family of proteins and their relation to signal transduction, vesicle trafficking, and diseases associated with aberrations in membrane biosynthesis and organization.
    Type: Grant
    Filed: February 25, 2000
    Date of Patent: December 17, 2002
    Assignee: The Salk Institute for Biological Studies
    Inventors: Greg Erwin Lemke, Andrew Do Nguyen, Ralf Krappa