Patents by Inventor Ralf Kraus
Ralf Kraus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230251253Abstract: An electrochemiluminescence method of detecting an analyte in a liquid sample and a corresponding analysis system. An analyte in a liquid sample is detected by first providing a receptacle containing a fluid comprising protein coated magnetic microparticles to a stirring unit. Stirring of the fluid is necessary since the density of the microparticles is usually higher than the density of the buffer fluid. Thus the microparticles tend to deposit on the bottom of the receptacle leading to an aggregation of the microparticles because of weak interactions. To obtain representative measurements a homogeneous distribution of the microparticles in the buffer fluid is necessary to ensure a constant concentration of microparticles for each analysis cycle. It is further necessary to provide disaggregation of the microparticles, which is also realized by stirring the fluid. Stirring is conducted with a rotational frequency that is adapted to the amount of fluid to be stirred.Type: ApplicationFiled: April 14, 2023Publication date: August 10, 2023Applicants: Roche Diagnostics Operations, Inc., Hitachi High-Tech CorporationInventors: Ralf Kraus, Oliver Larbolette, Friedrich Staebler, Yoshihiro Yamashita, Yukinori Sakashita, Shinya Matsuoka, Michihiro Saito, Taku Sakazume, Katsuaki Takahashi
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Patent number: 11703504Abstract: An electrochemiluminescence method of detecting an analyte in a liquid sample and a corresponding analysis system. An analyte in a liquid sample is detected by first providing a receptacle containing a fluid comprising protein coated magnetic microparticles to a stirring unit. Stirring of the fluid is necessary since the density of the microparticles is usually higher than the density of the buffer fluid. Thus the microparticles tend to deposit on the bottom of the receptacle leading to an aggregation of the microparticles because of weak interactions. To obtain representative measurements a homogeneous distribution of the microparticles in the buffer fluid is necessary to ensure a constant concentration of microparticles for each analysis cycle. It is further necessary to provide disaggregation of the microparticles, which is also realized by stirring the fluid. Stirring is conducted with a rotational frequency that is adapted to the amount of fluid to be stirred.Type: GrantFiled: September 5, 2019Date of Patent: July 18, 2023Assignees: ROCHE DIAGNOSTICS OPERATIONS, INC., HITACHI HIGH-TECH CORPORATIONInventors: Ralf Kraus, Oliver Larbolette, Friedrich Staebler, Yoshihiro Yamashita, Yukinori Sakashita, Shinya Matsuoka, Michihiro Saito, Taku Sakazume, Katsuaki Takahashi
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Publication number: 20210349112Abstract: There is provided an automatic analyzer that can reduce a cleaning agent used for cleaning a puddle configured to stir a reagent including a fine particle. An automatic analyzer including a reagent container configured to accommodate a reagent including a fine particle, a puddle configured to stir the reagent, and a cleaning unit configured to immerse the puddle in a cleaning vessel reserving a cleaning agent. The automatic analyzer further includes a determining unit configured to determine whether to totally replace the cleaning agent based on a score computed using a number of times of cleaning the puddle having stirred the reagent in the cleaning unit and a remaining amount of the reagent. When the determining unit determines that the cleaning agent is totally replaced, the cleaning unit displays, on a screen, a notification of total replacement of the cleaning agent, or recommendation of the total replacement.Type: ApplicationFiled: January 20, 2020Publication date: November 11, 2021Inventors: Koshin HAMASAKI, Eiichiro TAKADA, Shigeki MATSUBARA, Tatsuya FUKUGAKI, Stefan KOBEL, Ralf KRAUS
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Publication number: 20200003768Abstract: An electrochemiluminescence method of detecting an analyte in a liquid sample and a corresponding analysis system. An analyte in a liquid sample is detected by first providing a receptacle containing a fluid comprising protein coated magnetic microparticles to a stirring unit. Stirring of the fluid is necessary since the density of the microparticles is usually higher than the density of the buffer fluid. Thus the microparticles tend to deposit on the bottom of the receptacle leading to an aggregation of the microparticles because of weak interactions. To obtain representative measurements a homogeneous distribution of the microparticles in the buffer fluid is necessary to ensure a constant concentration of microparticles for each analysis cycle. It is further necessary to provide disaggregation of the microparticles, which is also realized by stirring the fluid. Stirring is conducted with a rotational frequency that is adapted to the amount of fluid to be stirred.Type: ApplicationFiled: September 5, 2019Publication date: January 2, 2020Applicants: Roche Diagnostics Operations, Inc., Hitachi High-Technologies CorporationInventors: Ralf Kraus, Oliver Larbolette, Friedrich Staebler, Yoshihiro y Yamashita, Yukinori Sakashita, Shinya Matsuoka, Michihiro Saito, Taku Sakazume, Katsuaki Takahashi
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Patent number: 10422797Abstract: An electrochemiluminescence method of detecting an analyte in a liquid sample and a corresponding analysis system. An analyte in a liquid sample is detected by first providing a receptacle containing a fluid comprising protein coated magnetic microparticles to a stirring unit. Stirring of the fluid is necessary since the density of the microparticles is usually higher than the density of the buffer fluid. Thus the microparticles tend to deposit on the bottom of the receptacle leading to an aggregation of the microparticles because of weak interactions. To obtain representative measurements a homogeneous distribution of the microparticles in the buffer fluid is necessary to ensure a constant concentration of microparticles for each analysis cycle. It is further necessary to provide disaggregation of the microparticles, which is also realized by stirring the fluid. Stirring is conducted with a rotational frequency that is adapted to the amount of fluid to be stirred.Type: GrantFiled: December 14, 2015Date of Patent: September 24, 2019Assignees: ROCHE DIAGNOSTICS OPERATIONS, INC., HITACHI HIGH-TECHNOLOGIES CORPORATIONInventors: Ralf Kraus, Oliver Larbolette, Friedrich Staebler, Yoshihiro Yamashita, Yukinori Sakashita, Shinya Matsuoka, Michihiro Saito, Taku Sakazume, Katsuaki Takahashi
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Publication number: 20160097765Abstract: An electrochemiluminescence method of detecting an analyte in a liquid sample and a corresponding analysis system. An analyte in a liquid sample is detected by first providing a receptacle containing a fluid comprising protein coated magnetic microparticles to a stirring unit. Stirring of the fluid is necessary since the density of the microparticles is usually higher than the density of the buffer fluid. Thus the microparticles tend to deposit on the bottom of the receptacle leading to an aggregation of the microparticles because of weak interactions. To obtain representative measurements a homogeneous distribution of the microparticles in the buffer fluid is necessary to ensure a constant concentration of microparticles for each analysis cycle. It is further necessary to provide disaggregation of the microparticles, which is also realized by stirring the fluid. Stirring is conducted with a rotational frequency that is adapted to the amount of fluid to be stirred.Type: ApplicationFiled: December 14, 2015Publication date: April 7, 2016Inventors: Ralf Kraus, Oliver Larbolette, Friedrich Staebler, Yoshihiro Yamashita, Yukinori Sakashita, Shinya Matsuoka, Michihiro Saito, Taku Sakazume, Kenichi Takahashi
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Patent number: 7980903Abstract: An installation switch has an insulating housing and a terminal connecting arrangement for clamping a connecting conductor having an annular terminal shoe. The terminal connecting arrangement includes a terminal socket having an interior disposed between an insertion opening for receiving the terminal shoe and an access opening and a terminal screw having a screw head and a screw shank disposed in the interior of the terminal socket, the screw being actuatable in a longitudinal direction within the interior of the terminal socket between an open state and a clamped state. The arrangement further includes a connection plate having a screw hole with interior threads for threadably engaging the terminal screw when in the clamped state and a retaining device preventing the terminal screw from being removed from the terminal socket when in the open state.Type: GrantFiled: March 11, 2010Date of Patent: July 19, 2011Assignee: ABB AGInventors: Matthias Bitz, Ralf Kraus, Klaus-Peter Eppe
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Publication number: 20100227513Abstract: An installation switch has an insulating housing and a terminal connecting arrangement for clamping a connecting conductor having an annular terminal shoe. The terminal connecting arrangement includes a terminal socket having an interior disposed between an insertion opening for receiving the terminal shoe and an access opening and a terminal screw having a screw head and a screw shank disposed in the interior of the terminal socket, the screw being actuatable in a longitudinal direction within the interior of the terminal socket between an open state and a clamped state. The arrangement further includes a connection plate having a screw hole with interior threads for threadably engaging the terminal screw when in the clamped state and a retaining device preventing the terminal screw from being removed from the terminal socket when in the open state.Type: ApplicationFiled: March 11, 2010Publication date: September 9, 2010Applicant: ABB AGInventors: Matthias Bitz, Ralf Kraus, Klaus-Peter Eppe
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Patent number: 7704105Abstract: An installation switch having a housing and a connecting arrangement for a conductor having a terminal shoe. The connecting arrangement includes a socket having an interior, an insertion opening, and an access opening, and a screw having a screw head and a screw shank disposed in the interior of the socket. The screw is actuatable longitudinally between an open and a clamped state. The arrangement further includes a connection plate having a screw hole with threads for threadably engaging the screw when in the clamped state, and a retaining device preventing the screw from being removed when in the open state. The arrangement is configured so that the open state allows the shoe to be inserted into the insertion opening, the clamped state provides the screw being engaged with the shoe, and access to the screw is provided via the access opening of the socket to actuate the screw.Type: GrantFiled: August 20, 2008Date of Patent: April 27, 2010Assignee: ABB AGInventors: Matthias Bitz, Ralf Kraus, Klaus-Peter Eppe
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Publication number: 20090053927Abstract: An installation switch having a housing and a connecting arrangement for a conductor having a terminal shoe. The connecting arrangement includes a socket having an interior, an insertion opening, and an access opening, and a screw having a screw head and a screw shank disposed in the interior of the socket. The screw is actuatable longitudinally between an open and a clamped state. The arrangement further includes a connection plate having a screw hole with threads for threadably engaging the screw when in the clamped state, and a retaining device preventing the screw from being removed when in the open state. The arrangement is configured so that the open state allows the shoe to be inserted into the insertion opening, the clamped state provides the screw being engaged with the shoe, and access to the screw is provided via the access opening of the socket to actuate the screw.Type: ApplicationFiled: August 20, 2008Publication date: February 26, 2009Applicant: ABB AGInventors: Matthias Bitz, Ralf Kraus, Klaus-Peter Eppe