Patents by Inventor Ralf Lesche

Ralf Lesche has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240317847
    Abstract: The present invention is related to agents capable of binding to and inhibiting or antagonizing the action of IL-11 and/or IL-11RA for the treatment and/or prevention of abnormal uterine bleeding, which comprises heavy menstrual bleeding, prolonged bleeding, altered bleeding pattern, dysmenorrhea, as well as of the underlying diseases leiomyoma and endometriosis and the use of the agent to inhibit menstruation. Furthermore, the invention provides novel IL-11 antibodies.
    Type: Application
    Filed: February 24, 2022
    Publication date: September 26, 2024
    Applicant: BAYER AKTIENGESELLSCHAFT
    Inventors: Maik Stefan Wilhelm OBENDORF, Frank SACHER, Jörg MÜLLER, Ralf LESCHE, Christian VOTSMEIER, Stephan MÄRSCH, Jan TEBBE, Philipp ELLINGER, Patrick Michael SMITH, Jenny FITTING, Katharina FILARSKY, Mathias GEHRMANN, Marcus KARLSTETTER, Ernst WEBER, Mark TRAUTWEIN
  • Publication number: 20240124572
    Abstract: The present invention is related to agents capable of binding to and inhibiting or antagonizing the action of IL-11 and/or or IL-11RA for the treatment and/or prevention of abnormal uterine bleeding, which comprises heavy menstrual bleeding, prolonged bleeding, altered bleeding pattern, dysmenorrhea, as well as of the underlying diseases leiomyoma and endometriosis and the use of the agent to inhibit menstruation. Furthermore, the invention provides novel IL-11 antibodies.
    Type: Application
    Filed: February 24, 2022
    Publication date: April 18, 2024
    Inventors: Maik Stefan Wilhelm OBENDORF, Frank SACHER, Jörg MÜLLER, Ralf LESCHE, Christian VOTSMEIER, Stephan MÄRSCH, Jan TEBBE, Philipp ELLINGER, Patrick Michael SMITH, Jenny FITTING, Katharina FILARSKY, Mathias GEHRMANN, Marcus KARLSTETTER, Ernst WEBER, Mark TRAUTWEIN
  • Publication number: 20220249458
    Abstract: The present invention is related to agonist of adiponectin receptor 1 (AdipoR1) and/or adiponectin receptor 2 (AdipoR2) for the treatment and/or prevention of polycystic ovary syndrome (PCOS).
    Type: Application
    Filed: March 30, 2020
    Publication date: August 11, 2022
    Inventors: Bernd ELGER, Martin FRITSCH, Oliver Martin FISCHER, Ralf LESCHE
  • Publication number: 20220154287
    Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
    Type: Application
    Filed: October 28, 2021
    Publication date: May 19, 2022
    Inventors: Catherine E. LOFTON-DAY, Andrew Z. SLEDZIEWSKI, Ralf LESCHE, Matthias SCHUSTER, Juergen DISTLER, Reimo TETZNER, Thomas HILDMANN, Fabian MODEL, Xiaoling SONG
  • Patent number: 11186879
    Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
    Type: Grant
    Filed: June 26, 2019
    Date of Patent: November 30, 2021
    Assignee: EPIGENOMICS AG
    Inventors: Catherine E. Lofton-Day, Andrew Z. Sledziewski, Ralf Lesche, Matthias Schuster, Juergen Distler, Reimo Tetzner, Thomas Hildmann, Fabian Model, Xiaoling Song
  • Publication number: 20190316210
    Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
    Type: Application
    Filed: June 26, 2019
    Publication date: October 17, 2019
    Inventors: Catherine E. Lofton-Day, Andrew Z. Sledziewski, Ralf Lesche, Matthias Schuster, Juergen Distler, Reimo Tetzner, Thomas Hildmann, Fabian Model, Xiaoling Song
  • Patent number: 10385402
    Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: August 20, 2019
    Assignee: EPIGENOMICS AG
    Inventors: Catherine E. Lofton-Day, Andrew Z. Sledziewski, Ralf Lesche, Matthias Schuster, Juergen Distler, Reimo Tetzner, Thomas Hildmann, Fabian Model, Xiaoling Song
  • Patent number: 10053735
    Abstract: The present invention relates to methods for predicting the outcome of anthracycline treatment of cell proliferative disorder patients. This is achieved by determining the expression level of at least one gene selected from the group consisting of PITX2; TFF1 and PLAU. The invention also relates to sequences, oligonucleotides and antibodies which can be used within the described methods.
    Type: Grant
    Filed: September 21, 2006
    Date of Patent: August 21, 2018
    Assignee: THERAWIS DIAGNOSTICS GMBH
    Inventors: John Foekens, John W. Martens, Serenella Eppenberger-Castori, Vincent Vuaroqueaux, Frederique Spyratos, Nadia Harbeck, Manfred Schmitt, Heinz Hoefler, Sabine Maier, Gunter Weiss, Ralf Lesche, Thomas Hildmann, Achim Plum
  • Patent number: 9988683
    Abstract: Provided are methods and nucleic acids for detecting, differentiating or distinguishing between colon cell proliferative disorders by analysis of one or more of the genes Versican, TPEF, H-Cadherin, Calcitonin, and EYA4. Further provided are novel nucleic acid sequences useful for the cell proliferative disorder specific analysis of said genes as well as methods, assays and kits thereof.
    Type: Grant
    Filed: June 4, 2010
    Date of Patent: June 5, 2018
    Assignee: EPIGENOMICS AG
    Inventors: Peter Adorjan, Matthias Burger, Sabine Maier, Ralf Lesche, Susan Cottrell, Suzanne Mooney
  • Patent number: 9695478
    Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
    Type: Grant
    Filed: May 13, 2010
    Date of Patent: July 4, 2017
    Assignee: EPIGENOMICS AG
    Inventors: Catherine E. Lofton-Day, Andrew Z. Sledziewski, Ralf Lesche, Matthias Schuster, Juergen Distler, Reimo Tetzner, Thomas Hildmann, Fabian Model, Xiaoling Song
  • Patent number: 9670546
    Abstract: The invention provides methods, nucleic acids and kits for determining the prognosis of a subject having cell proliferative disorder, preferably cancer. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of said disorder, thereby enabling the improved diagnosis and treatment of patients.
    Type: Grant
    Filed: July 15, 2009
    Date of Patent: June 6, 2017
    Assignee: EPIGENOMICS AG
    Inventors: Dimo Dietrich, Ralf Lesche, Anne Fassbender, Manuel Krispin, Joern Dietrich
  • Publication number: 20160304964
    Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
    Type: Application
    Filed: March 23, 2016
    Publication date: October 20, 2016
    Inventors: Catherine E. Lofton-Day, Andrew Z. Sledziewski, Ralf Lesche, Matthias Schuster, Juergen Distler, Reimo Tetzner, Thomas Hildmann, Fabian Model, Xiaoling Song
  • Publication number: 20150275312
    Abstract: The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes for use in the differentiation, diagnosis, treatment and/or monitoring of colon cell proliferative disorders, or the predisposition to colon cell proliferative disorders.
    Type: Application
    Filed: November 25, 2014
    Publication date: October 1, 2015
    Inventors: Peter Adorjan, Matthias Burger, Sabine Maier, Inko Nimmrich, Evelyne Becker, Ralf Lesche, Tamas Rujan, Armin Schmitt
  • Patent number: 9017944
    Abstract: The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the disease free survival and/or response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.
    Type: Grant
    Filed: December 13, 2004
    Date of Patent: April 28, 2015
    Assignee: Epigenomics AG
    Inventors: John Foekens, Nadia Harbeck, Thomas Koenig, Sabine Maier, John W. Martens, Fabian Model, Inko Nimmrich, Manfred Schmitt, Ralf Lesche, Dimo Dietrich, Volkmar Mueller, Antje Kluth Lukas, Ina Schwope, Oliver Hartmann, Peter Adorjan, Almuth Marx, Heinz Hoefler
  • Publication number: 20150086989
    Abstract: Aspects of the invention provide methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. Particular aspects disclose and provide genomic sequences the methylation patterns of which have substantial utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
    Type: Application
    Filed: November 19, 2014
    Publication date: March 26, 2015
    Inventors: Juergen Distler, Thomas Hildmann, Ralf Lesche, Catherine Lofton-Day, Fabian Model, Matthias Schuster, Andrew Z. Sledziewski, Reimo Tetzner, Xiaoling Song
  • Patent number: 8900829
    Abstract: Aspects of the invention provide methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. Particular aspects disclose and provide genomic sequences the methylation patterns of which have substantial utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: December 2, 2014
    Assignee: Epigenomics AG
    Inventors: Juergen Distler, Thomas Hildmann, Ralf Lesche, Catherine Lofton-Day, Fabian Model, Matthias Schuster, Andrew Z. Sledziewski, Reimo Tetzner, Xiaoling Song
  • Publication number: 20140179563
    Abstract: The invention provides methods and nucleic acids for detecting, differentiating or distinguishing between colon cell proliferative disorders as well as therapy thereof by analysis of the gene EYA4 and its promoter and regulatory sequences. The invention further provides novel nucleic acid sequences useful for the cell proliferative disorder specific analysis of said gene as well as methods, assays and kits thereof.
    Type: Application
    Filed: February 21, 2014
    Publication date: June 26, 2014
    Applicant: Epigenomics AG
    Inventors: Peter Adorjan, Matthias Burger, Sabine Maier, Ralf Lesche, Susan Cottrell, Theo De Vos
  • Patent number: 8691503
    Abstract: The invention provides methods and nucleic acids for detecting, differentiating or distinguishing between colon cell proliferative disorders as well as therapy thereof by analysis of the gene EYA4 and its promoter and regulatory sequences. The invention further provides novel nucleic acid sequences useful for the cell proliferative disorder specific analysis of said gene as well as methods, assays and kits thereof.
    Type: Grant
    Filed: February 13, 2003
    Date of Patent: April 8, 2014
    Assignee: Epigenomics AG
    Inventors: Peter Adorjan, Matthias Burger, Sabine Maier, Ralf Lesche, Susan Cottrell, Theo De Vos
  • Publication number: 20120328518
    Abstract: This invention relates to novel compounds suitable for labelling by 18F and the corresponding 18F labelled compounds themselves, 19F-fluorinated analogues thereof and their use as reference standards, methods of preparing such compounds, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging by positron emission tomography (PET).
    Type: Application
    Filed: December 16, 2010
    Publication date: December 27, 2012
    Applicant: PIRAMAL IMAGING SA
    Inventors: Keith Graham, Georg Kettschau, Ralf Lesche, Alexey Gromov, Niels Bohnke, Jorma Hassfeld
  • Publication number: 20120129729
    Abstract: Particular aspects relate to a method for determining the methylation pattern of a polynucleic acid, comprising: a) preparing a solution comprising a mixture of fragments of the polynucleic acid; b) coupling the fragments with a substance being detectable with a detection method; c) contacting a solution comprising the fragments of b) with a DNA microarray having a plurality of different immobilized oligonucleotides, each comprising at least one methylation site, at respectively assigned different locations thereon, the contacting under conditions affording hybridization of fragments with correlated immobilized oligonucleotides under defined stringency, and wherein the immobilized oligonucleotides have a length of less than 200 bases; d) optionally performing a washing step; and e) detecting, using the physical detection method, such immobilized nucleic acids to which solution fragments are hybridized and/or to which solution fragments are not hybridized.
    Type: Application
    Filed: April 4, 2011
    Publication date: May 24, 2012
    Applicant: Epigenomics AG
    Inventors: Anne Fassbender, Ralf Lesche, Juergen Distler, Christian Piepenbrock, Tamas Rujan, Kurt Berlin, Thomas Koenig