Patents by Inventor Ralf Lock

Ralf Lock has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for preparing tiotropium salts
    Patent number: 8008495
    Abstract: The invention relates to a new process for preparing tiotropium salts of general formula 1 wherein X? may have the meanings given in the claims and in the specification.
    Type: Grant
    Filed: January 5, 2009
    Date of Patent: August 30, 2011
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Ralf Lock, Werner Belzer, Rainer Hamm, Monika Hofmann
  • Process for preparation of isochroman and derivatives thereof
    Patent number: 7534812
    Abstract: The present invention relates to an improved process for preparing compounds of formula 1 on an industrial scale, wherein R1, R2 and R3 are independently C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl or aryl; and R4 is H, OC1-6-alkyl, Oaryl, OH, C1-6-alkyl, halogen, CN or NO2.
    Type: Grant
    Filed: January 26, 2006
    Date of Patent: May 19, 2009
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventor: Ralf Lock
  • New method for preparing tiotropium salts
    Publication number: 20090118511
    Abstract: The invention relates to a new process for preparing tiotropium salts of general formula 1 wherein X? may have the meanings given in the claims and in the specification.
    Type: Application
    Filed: January 5, 2009
    Publication date: May 7, 2009
    Applicant: BOEHRINGER INGELHEIM PHARMA GMBH & CO., KG
    Inventors: Ralf LOCK, Werner BELZER, Rainer HAMM, Monika HOFMANN
  • Method for preparing tiotropium salts
    Patent number: 7491824
    Abstract: The invention relates to a new process for preparing tiotropium salts of general formula 1 wherein X? may have the meanings given in the claims and in the specification.
    Type: Grant
    Filed: August 23, 2005
    Date of Patent: February 17, 2009
    Assignee: Boehringer Ingelheim Pharma GmbH & Co., KG
    Inventors: Ralf Lock, Werner Belzer, Rainer Hamm, Monika Hofmann
  • PROCESS FOR PREPARING 6-ARYL-4H-S-TRIAZOLO[3,4-c]-THIENO[2,3-e]-1,4-DIAZEPINES
    Publication number: 20070232799
    Abstract: An improved process for preparing 6-aryl-4H-s-triazolo[3,4-c]-thieno[2,3-e]-1,4-diazepines of formula I, wherein: R1 is a hydrogen or halogen atom or a C1-C6 alkyl group, R2 is a hydrogen or halogen atom or a C1-C6 alkyl, C1-C6 hydroxyalkyl, C3-C6 cycloalkyl group or a 5- or 6-membered oxygen-, sulphur- or nitrogen-containing heterocyclic group which may optionally be substituted at the nitrogen atom by a C1-C3 alkyl group, and R3 is a hydrogen or halogen atom.
    Type: Application
    Filed: May 17, 2007
    Publication date: October 4, 2007
    Inventors: Werner Belzer, Ralf Lock
  • Process for Preparation of Isochroman and Derivatives Thereof
    Publication number: 20060173196
    Abstract: The present invention relates to an improved process for preparing compounds of formula 1 on an industrial scale, wherein R1, R2 and R3 are independently C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl or aryl; and R4 is H, OC1-6-alkyl, Oaryl, OH, C1-6-alkyl, halogen, CN or NO2.
    Type: Application
    Filed: January 26, 2006
    Publication date: August 3, 2006
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventor: Ralf Lock
  • New method for preparing tiotropium salts
    Publication number: 20060047120
    Abstract: The invention relates to a new process for preparing tiotropium salts of general formula 1 wherein X? may have the meanings given in the claims and in the specification.
    Type: Application
    Filed: August 23, 2005
    Publication date: March 2, 2006
    Applicant: Boehringer Ingelheim Pharma GmbH & Co., KG
    Inventors: Ralf Lock, Werner Belzer, Rainer Hamm, Monika Hofmann
  • Process for preparing 6-aryl-4H-S-triazolo[3,4-c]-thieno[2,3-e]-1,4-diazepines
    Publication number: 20050148579
    Abstract: An improved process for preparing 6-aryl-4H-s-triazolo[3,4-c]-thieno[2,3-e]-1,4-diazepines of formula I, wherein: R1 is a hydrogen or halogen atom or a C1-C6 alkyl group, R2 is a hydrogen or halogen atom or a C1-C6 alkyl, C1-C6 hydroxyalkyl, C3-C6 cycloalkyl group or a 5- or 6-membered oxygen-, sulphur- or nitrogen-containing heterocyclic group which may optionally be substituted at the nitrogen atom by a C1-C3 alkyl group, and R3 is a hydrogen or halogen atom,
    Type: Application
    Filed: March 7, 2005
    Publication date: July 7, 2005
    Applicant: Boehringer Ingelheim Pharma KG
    Inventors: Werner Belzer, Ralf Lock
  • Process for preparing 6-aryl-4H-S-triazolo[3,4-c]-thieno[2,3-e]-1,4-diazepines
    Patent number: 6884886
    Abstract: An improved process for preparing 6-aryl-4H-s-triazolo[3,4-c]-thieno[2,3-e]-1,4-diazepines of formula I, wherein: R1 is a hydrogen or halogen atom or a C1-C6 alkyl group, R2 is a hydrogen or halogen atom or a C1-C6 alkyl, C1-C6 hydroxyalkyl, C3-C6 cycloalkyl group or a 5- or 6-membered oxygen-, sulphur- or nitrogen-containing heterocyclic group which may optionally be substituted at the nitrogen atom by a C1-C3 alkyl group, and R3 is a hydrogen or halogen atom.
    Type: Grant
    Filed: March 13, 2002
    Date of Patent: April 26, 2005
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Werner Belzer, Ralf Lock
  • Intermediates useful for preparing 4,6-diaminopyrido[5,4-d]pyrimidines
    Patent number: 6849734
    Abstract: 2-Chloro-4,6-diamino-7,8-dihydropyrimido[5,4-d]pyrimidine of the formula II wherein R1 denotes a hydrogen atom or a C1-C6 alkyl group, R2 denotes an optionally substituted C6-C10 aryl group, R3 denotes a hydrogen atom or a C1-C6 alkyl group, and R4 denotes a hydrogen atom or an optionally substituted C1-C6 alkyl, C3-C6 alkenyl, C3-C8 cycloalkyl or a 4- to 7-membered, nitrogen-containing heterocyclyl group, or R3 and R4 together with the nitrogen atom linked to them denote an optionally substituted heterocyclyl group, and PG1 denotes a C1-6 alkanoyl group.
    Type: Grant
    Filed: September 25, 2003
    Date of Patent: February 1, 2005
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Werner Belzer, Ralf Lock, Werner Rall
  • Intermediates useful for preparing 4,6-diaminopyrido[5,4-d]pyrimidines
    Publication number: 20040059114
    Abstract: Intermediates useful for preparing 4,6-diaminopyrimido[5,4-d]pyrimidines, which are themselves useful as inhibitors of signal transduction mediated by tyrosine kinases. The intermediates of the invention are 2-chloro-4,6-diamino-7,8-dihydropyrimido[5,4-d]pyrimidines, protected and unprotected 4-amino-2,6-dichloro-7,8-dihydropyrimido[5,4-d]pyrimidines and 4-amino-2,6,8-trichloropyrimido[5,4-d]pyrimidines.
    Type: Application
    Filed: September 25, 2003
    Publication date: March 25, 2004
    Applicant: Boehringer Ingelheim Pharma KG
    Inventors: Werner Belzer, Ralf Lock, Werner Rall
  • Process for preparing 4,6-diaminopyrimido[5,4-d]pyrimidines
    Patent number: 6680384
    Abstract: The present invention relates to a process for preparing 4,6-diaminopyrimido[5,4-d]pyrimidines of formula I, wherein R1 to R4 have the meanings given in claim 1, as well as new intermediate products which are involved in this process.
    Type: Grant
    Filed: March 12, 2002
    Date of Patent: January 20, 2004
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Werner Belzer, Ralf Lock, Werner Rall
  • Process for preparing 4,6-diaminopyrimido[5,4-d]pyrimidines
    Publication number: 20020198380
    Abstract: A process for preparing 4,6-diaminopyrimido[5,4-d]pyrimidines of formula I, 1
    Type: Application
    Filed: March 12, 2002
    Publication date: December 26, 2002
    Inventors: Werner Belzer, Ralf Lock, Werner Rall
  • Process for preparing 6-aryl-4H-S-triazolo[3,4-c]-thieno[2,3-e]-1,4-diazepines
    Publication number: 20020147190
    Abstract: An improved process for preparing 6-aryl-4H-s-triazolo[3,4-c]-thieno[2,3-e]-1,4-diazepines of formula I, 1
    Type: Application
    Filed: March 13, 2002
    Publication date: October 10, 2002
    Inventors: Werner Belzer, Ralf Lock