Abstract: The present disclosure relates to a composition comprising a first set of probes and a second set of probes, composed of one or more DNA nucleotide(s) and five or more LNA (locked nucleic acid) nucleotides, wherein the base at a discriminating position differs for a first probe of the first set and a first probe of the second set. The present disclosure relates to the composition comprising a plurality of probes in each of the first and second set of probes, wherein the probes in each set differ in one, two, or three LNA random position(s). Further, the present disclosure relates to a method of detecting genomic variants by means of the aforementioned probes.

Abstract: The invention relates to a method for producing biopolymer arrays comprising a porous membrane and bound biopolymers. In particular, said production of biopolymer arrays comprises electrochemical production cycles.

Abstract: The present invention relates to a method, a substrate, a kit, and a system for nucleic acid amplification comprising a porous substrate with pores enabling the diffusion of biomolecules. More particular, the present invention relates to a method, a substrate, a kit and a system, wherein the nucleic acid amplification takes place within the pores of a porous substrate.

Abstract: The present invention relates to a microfluid reaction carrier intended for the purely fluid or light-controlled synthesis or analysis of oligomers or polymers. The reaction carrier comprises a structure of flow channels for the fluids, while supply channels and discharge channels parallel to the latter form an angle relative to the plane of the structure of the flow channels (reaction areas).

Abstract: The invention relates to a method for producing biopolymer arrays comprising a porous membrane and bound biopolymers. In particular, said production of biopolymer arrays comprises electrochemical production cycles.

Abstract: The invention relates to a quality control method for manufacturing biopolymer arrays comprising (a) synthesizing a plurality of different biopolymer species on an array from monomeric or oligomeric building blocks comprising detectable protecting groups; (b) optionally carrying out a determination of the detectable protecting groups on the array after synthesis; (c) cleaving off the detectable protecting groups; and (d) carrying out a determination of the detectable protecting groups on the array after cleavage in order to determine the efficacy of deprotection.

Abstract: The invention relates to a method and a device for the production of a carrier, in particular a microfluidic carrier, for determining analytes.