Abstract: The present invention relates to bispecific antibodies against ROR1 and CD3, their manufacture and use.

Abstract: Device for mixing at least two chemically reactive plastics components under pressure, having a mixing chamber, into which the plastics components are injected in each case by way of a component-feeding opening, wherein a reversible control piston is provided for opening and closing the component-feeding openings and for discharging plastics mixture remaining within the mixing chamber, wherein the control piston is connected to an electric drive. Alternatively, in the case of a transfer mixing head, the cleaning piston may be coupled to an electric drive. A method for operating such a mixing head is also disclosed.

Abstract: A mixing device and method for generating reaction plastic, the mixing device including: a mixing chamber configured to mix reactive components to generate the reaction plastic; a discharge unit, including a discharge pipe connected to the mixing chamber configured to discharge the reaction plastic generated in the mixing chamber; a cleaning piston that is axially aligned with the discharge pipe of the discharge unit and is moveable into the discharge pipe to clean reaction plastic from the discharge pipe; a fluid supply device configured to provide a lubricant into the discharge unit via an outlet to lubricate the discharge unit, a control piston arranged within the mixing chamber and configured to control flow of the reactive components; wherein an axial direction of the control piston is oblique to an axial direction of a discharge pipe of the discharge unit.

Abstract: An optical arrangement of an imaging device for microlithography, particularly for using light in the extreme UV range, includes an optical element and a holding device for holding the optical element. The optical element includes an optical surface and defines a plane of main extension, in which the optical element defines a radial direction and a circumferential direction. The holding device includes a base element and more than three separate holding units. The holding units are connected to the base element and arranged in a manner distributed along the circumferential direction and spaced apart from one another. The holding units hold the optical element with respect to the base element. Each of the holding units establishes a clamping connection between the optical element and the base element. The clamping connection for each holding unit is separate from the clamping connections of the other holding units.

Abstract: An optical arrangement of an imaging device for microlithography, particularly for using light in the extreme UV range, includes an optical element and a holding device for holding the optical element. The optical element includes an optical surface and defines a plane of main extension, in which the optical element defines a radial direction and a circumferential direction. The holding device includes a base element and more than three separate holding units. The holding units are connected to the base element and arranged in a manner distributed along the circumferential direction and spaced apart from one another. The holding units hold the optical element with respect to the base element. Each of the holding units establishes a clamping connection between the optical element and the base element. The clamping connection for each holding unit is separate from the clamping connections of the other holding units.

Abstract: A method produces or machines a roller which is suitable to be used in a machine for producing or processing a fibrous web. The roller contains a roller core and at least one functional layer. The method is characterized in that the method includes the application of a functional layer. The application of the functional layer is performed by applying a coating substrate to the surface of a roller core. The application takes place simultaneously over at least half the roller width, preferably over 75% of the roller width, particularly preferably over the entire roller width. The entire applied coating substrate or parts thereof are hardened, forming a solidified structure.

Abstract: The disclosure relates to an optical element, in particular for a microlithographic projection exposure apparatus. The optical element has an optical effective surface. The optical element includes a substrate, a layer system that is present on the substrate, and a protective cover extending over an edge region of the optical element that is adjacent to the optical effective surface. During operation of the optical element, the protective coating reduces an ingress of hydrogen radicals into the layer system in comparison with an analogous design without the protective cover, wherein a gap is formed between the protective cover and the layer system.

Abstract: The disclosure relates to an optical element, in particular for a microlithographic projection exposure apparatus. The optical element has an optical effective surface. The optical element includes a substrate, a layer system that is present on the substrate, and a protective cover extending over an edge region of the optical element that is adjacent to the optical effective surface. During operation of the optical element, the protective coating reduces an ingress of hydrogen radicals into the layer system in comparison with an analogous design without the protective cover, wherein a gap is formed between the protective cover and the layer system.

Abstract: A component feed nozzle includes a housing, which has a component inlet and a component outlet, a piston-shaped closing body, which is slidably supported in the housing and which can be moved back and forth axially. The component outlet is closed by the front end of the closing body in a first position and the component outlet is released or opened in a second position. The component feed nozzle has a membrane seal, which is fastened to the rear end of the closing body and to the housing in such a way that the closing body is completely on one face of the membrane seal. The housing and/or the closing body are designed in such a way that the component reaches all surfaces of the closing body and thus the component pressure is applied to the complete effective surface of the membrane.

Abstract: A method produces or machines a roller which is suitable to be used in a machine for producing or processing a fibrous web. The roller contains a roller core and at least one functional layer. The method is characterized in that the method includes the application of a functional layer. The application of the functional layer is performed by applying a coating substrate to the surface of a roller core. The application takes place simultaneously over at least half the roller width, preferably over 75% of the roller width, particularly preferably over the entire roller width. The entire applied coating substrate or parts thereof are hardened, forming a solidified structure.

Abstract: A component feed nozzle includes a housing, which has a component inlet and a component outlet, a piston-shaped closing body, which is slidably supported in the housing and which can be moved back and forth axially. The component outlet is closed by the front end of the closing body in a first position and the component outlet is released or opened in a second position. The component feed nozzle has a membrane seal, which is fastened to the rear end of the closing body and to the housing in such a way that the closing body is completely on one face of the membrane seal. The housing and/or the closing body are designed in such a way that the component reaches all surfaces of the closing body and thus the component pressure is applied to the complete effective surface of the membrane.

Abstract: A device for rapid short-circuit protection in a power semiconductor is described. It has at least one power semiconductor (10, 38) via which a load current (IL) may be applied to at least one electric load (24). The current detection means (14, 18, 46) provide a measure (VIS) of the load current (IL) applied to the electric load (24). A semiconductor protective circuit (30, 32, 34, 36) triggers the power semiconductor (10, 38) to protective operation in the event of an imminent impairment of the power semiconductor (10, 38).

Abstract: The microoptical device has beam-parallelizing optics and a deflecting mirror configuration. The device converts a laser beam bundle, which is emitted by a laser diode strip structure or individual diode chips and which is comprised of a plurality of strip-shaped individual laser beams, into a rectangular or parallelogram-shaped laser beam bundle composed of parallelized strip-shaped individual laser beams arranged parallel next to one another. The beam-parallelizing optics may be a cylindrical lens, and the deflecting mirror configuration may be two rows of mirrors. The cylindrical lens and the rows of mirrors are preferably produced from a semiconductor material and they can therefore be produced cost effectively by means of methods used in semiconductor process engineering.