Patents by Inventor Ralf Mrowka

Ralf Mrowka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Application of Imidazopyridine Derivatives in Regenerative Medicine
    Publication number: 20200062719
    Abstract: A method of producing a pluripotent stem cell is provided. The method is comprising contacting a non-pluripotent donor cell obtained from a mammalian donor with a compound characterized by general formulas (1) and (3). Furthermore, methods for inducing OCT4 and NANOG, increasing histone 3 lysine methylation and the maintenance of pluripotency are provided.
    Type: Application
    Filed: August 14, 2019
    Publication date: February 27, 2020
    Applicants: University of Heidelberg, Universitätsklinikum Jena
    Inventors: Xinlai Cheng, Stefan Wolfl, Ralf Mrowka, James Adjaye
  • Human microRNAs for treatment of malignant tumours
    Patent number: 10556019
    Abstract: The invention relates to a nucleic acid molecule for use in a method of treatment of cancer. The nucleic acid molecule comprises a sequence selected from SEQ ID NO 001 to SEQ ID NO 038. The nucleic acid molecules provided are not provided for the treatment of laryngeal cancer.
    Type: Grant
    Filed: August 23, 2016
    Date of Patent: February 11, 2020
    Assignee: UNIVERSITÄTSKLINIKUM JENA
    Inventors: Ralf Mrowka, Axel Gohring
  • HUMAN MICRORNAS FOR TREATMENT OF MALIGNANT TUMOURS
    Publication number: 20180264138
    Abstract: The invention relates to a nucleic acid molecule for use in a method of treatment of cancer. The nucleic acid molecule comprises a sequence selected from SEQ ID NO 001 to SEQ ID NO 038. The nucleic acid molecules provided are not provided for the treatment of laryngeal cancer.
    Type: Application
    Filed: August 23, 2016
    Publication date: September 20, 2018
    Applicant: UNIVERSITATSKLINIKUM JENA
    Inventors: Ralf MROWKA, Axel GOHRING
  • Method for activating Oct4 for induction of pluripotent stem cells
    Patent number: 9783786
    Abstract: The invention relates to a method for inducing pluripotent stem cells, wherein a mammalian cell is contacted with a compound characterized by a general formula 1 wherein R1 is (CH2)mE, with E being CCH or CN and m being 0, 1, or 2, and R2 is selected from F, CI, Br, OR3 and R3, with R3 being selected from H, (CHyF2-y)n CHXF3-X, with n=0 or 1. The invention further relates to stem cells obtained by the method of the invention, and culture media comprising the compound of the invention.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: October 10, 2017
    Assignees: UNIVERSITATSKLINIKUM JENA
    Inventors: Ralf Mrowka, Gunter Wolf, Stefan Wolfl, Xinlai Cheng