Abstract: A medicine for treatment of a carcinoma which can be supplied to the carcinoma via the circulatory system, contains two active components coupled to one another. The first active component is formed of at least one coupling molecule that specifically tethers to a target molecule formed by the cancer tissue. The second active component is formed of at least one signal molecule typical to inflammation, or of at least originating molecule encoding such a signal molecule.

Abstract: A diagnosis substance for application in a method for diagnosis of pathological tissue, contains at least one virus population with virus particles specifically binding to target molecules typical of a specific pathological tissue, with a label that is detectable with the use of a detection device being bound to the virus particles. In a method for production of such a diagnosis substance, the principle of directed biological evolution is applied.

Abstract: In a method for diagnosis and treatment of a patient with a tumor relating to prostate cancer, the following steps are implemented. A differential diagnosis of prostate cancer versus prostatitis and/or BPH is conducted on a patient using a cost-effective diagnosis method. If prostate cancer is diagnosed in the patient using a cost-effective measurement method, a characteristic value for the tumor aggressiveness of the prostate cancer is determined. A watchful waiting treatment is implemented with the patient given a characteristic value below a predeterminable first limit value. The size and position of the tumor is determined using a cost-effective method given a characteristic value above the first limit value. A cost-effective ultrasonic theranosis or a conventional therapy is conducted for a size below a second predeterminable limit value. The presence of metastases in the patient is checked, with a cost-intensive method generating image information, for a size above the second limit value.

Abstract: In a method for diagnosis and treatment of a patient with regard to prostatitis, a differential diagnosis of prostatitis versus prostate cancer and/or BPH is conducted on a patient using a cost-effective diagnosis method. Given diagnosed prostatitis, a cost-effective decision test is implemented on the patient to determine whether the patient exhibits complaints locally in the region of the prostate or in the rest of the body. A molecular inflammation marker is administered to the patient, wherein a cost-effective imaging method is implemented in the region of the prostate of the patient given local complaints or a cost-intensive imaging method is implemented on the entire patient given complaints in the rest of the body. An inflammation-inhibiting treatment is implemented in the body region of the patient that is detected as inflamed via the respective imaging method.

Abstract: In a method for imaging a prostate tumor in which a contrast agent that can be distributed via the circulatory system is administered to the patient, the contrast agent contains at least one type of biomarkers which are bound to a ferromagnetic particle and specifically bind to a target molecule typical of the tumor and formed within the tumor or in a tissue adjacent to the tumor. The imaging ensues with the use of magnetic resonance tomography.

Abstract: A contrast agent for ultrasound examination of the prostate has contrast-intensifying particles on an exterior of which at least one binding molecule is present that specifically binds to CEACAM-1. In a method for ultrasound examination of the prostate, such a contrast agent is administered to the patient and a sonography of the prostate is subsequently implemented.

Abstract: In a method and device for x-ray brachytherapy, a probe is inserted into and moved within a living subject, the probe having a distal end, an x-ray source carried by said probe at said distal end that irradiates an x-ray beam into an exposure area outside of the probe, a mark generator carried by said probe at said distal end that generates a mark that identifies at least a portion of said exposure area, and an optical observation system, having an optical detector carried at said distal of said probe, that generates an optical image of said at least one part of said exposure area that is identified by said marking, the marking being visible in said optical image.

Abstract: A bellows for coupling a source of acoustic waves having an acoustic propagation medium, to a patient, has a geometrical modification in that region wherein the bellows can be seated against the patient for the introduction of acoustic waves into the patient. The geometrical modification in the propagation path of the acoustic waves generated by the source of acoustic waves shapes the acoustic waves in a designated (designed) manner. Additionally or alternatively, the bellows can have a section in the region that is formed of a different material than the rest of the bellows.

Abstract: In a system and method for x-ray brachytherapy, a probe is introduced into the body of a subject, the probe carrying an x-ray source that radiates x-rays into an exposure area outside of the probe within the body of the subject. A number of markers are located in or on the probe, that are detectable in an image generated by an imaging device. The markers are located in or on the probe in a known spatial relation to the exposure area, so that the position of the exposure area can be determined by identifying the markers in the displayed image.

Abstract: A shockwave system for treatment of a patient has a detection unit for detection of an indicator correlated with the calmness of the patient, and a device that is operable dependent on the indicator that increases the calmness of the patient. In a method for operation of a shockwave system for treatment of a patient, an indicator correlated with the calmness of the patient is detected and a measure to increase the calmness of the patient is taken dependent on the indicator.

Abstract: A prostrate cancer detection apparatus has a measurement sensor for detection of at least one prostate cancer-specific biomarker, an evaluation unit for determination of at least one risk value from at least one prostate cancer-specific biomarker detected by the measurement sensor, and a display unit to display the at least one determined risk value.

Abstract: An optical hydrophone for measurement of the acoustic pressure distribution in a fluid medium has a light source that illuminates an area of a boundary region between an optically transparent body and the fluid medium. A light receiver measures the intensity of the light reflected from the illuminated area as a measurement of acoustic pressure, due to changes in the index of refraction of the fluid medium that are caused by the acoustic pressure. The illuminated area is smaller than the boundary surface formed between the optically transparent body and the fluid medium, thereby giving the hydrophone a longer service light and a high spatial resolution capacity.

Abstract: A shockwave system for treatment of a patient has a detection unit for detection of an indicator correlated with the calmness of the patient, and a device that is operable dependent on the indicator that increases the calmness of the patient. In a method for operation of a shockwave system for treatment of a patient, an indicator correlated with the calmness of the patient is detected and a measure to increase the calmness of the patient is taken dependent on the indicator.

Abstract: In a method for x-ray imaging given a patient containing a subject to be represented during a shockwave treatment, an image data set containing the subject and a marker is generated at a first point in time; an x-ray image showing essentially only the subject (14) and the marker is acquired at a second point in time, the x-ray image is correctly spatially associated with the image data set using the marker, the x-ray image is displayed together with information extracted from the image data set during the shockwave treatment.

Abstract: In a method to disintegrate a calculus in a patient by shockwave lithotripsy, a 3D image data set of the patient is generated in a first step; the shockwave lithotripsy is conducted in a second step; and first step and second step are conducted with an unchanged position of the patient. A lithotripsy system to disintegrate a calculus in a patient has a shockwave system to disintegrate the calculus and a 3D imaging system to generate a 3D image data set of the patient without movement of the patient.

Abstract: In a method to determine an operating parameter of a shockwave source for the generation of a shockwave to disintegrate a calculus in a patient by a shockwave lithotripsy, a characteristic of the patient and/or of the calculus is determined before and/or during the shockwave lithotripsy and the operating parameter is automatically determined dependent on the characteristic. A device for determining an operating parameter of a shockwave source for the destruction of a calculus in a patient has an acquisition and control unit for determination and/or input of a characteristic of the patient and/or of the calculus, and for automatic determination of the operating parameter dependent on the characteristic.

Abstract: In a shockwave system with a shockwave source for treatment of a patient with shockwaves, a control and evaluation unit for evaluating an input signal supplied directly thereto that is correlated with a blood pressure value of the patient determined during the treatment, and controls the shockwave source dependent on the input signal.

Abstract: An optical hydrophone for measurement of the acoustic pressure distribution in a fluid medium has a light source that illuminates an area of a boundary region between an optically transparent body and the fluid medium. A light receiver measures the intensity of the light reflected from the illuminated area as a measurement of acoustic pressure, due to changes in the index of refraction of the fluid medium that are caused by the acoustic pressure. The illuminated area is smaller than the boundary surface formed between the optically transparent body and the fluid medium, thereby giving the hydrophone a longer service light and a high spatial resolution capacity.

Abstract: A bellows for coupling a source of acoustic waves having an acoustic propagation medium, to a patient, has a geometrical modification in that region wherein the bellows can be seated against the patient for the introduction of acoustic waves into the patient . The geometrical modification in the propagation path of the acoustic waves generated by the source of acoustic waves shapes the acoustic waves in a designated (designed) manner. Additionally or alternatively, the bellows can have a section in the region that is formed of a different material than the rest of the bellows.