Abstract: The present invention relates to the use of iminooxothiazolidine derivatives for preventing or treating hair growth disorders. The iminooxothiazolidine derivatives may be formulated as compositions suitable for either the systemic administration or the local application to the scalp.

Abstract: In order to provide a new agent for actively controlling hair growth in subjects, the present disclosure is directed to an active agent for use in hair growth regulation, particularly for use in the treatment of hair growth (stimulation or inhibition), wherein the active agent activates, enhances, inactivates, blocks or dampens the cellular response of the transient receptor potential ion channel TRPM5 or interferes with the expression of the ion channel. Furthermore, the present disclosure is directed to compositions for use as a cosmetic or medicament in the treatment of hair growth; the composition comprising at least one of the aforementioned active agents and at least one auxiliary agent. In addition, a non-therapeutic method of hair growth regulation is disclosed, wherein an effective amount of at least one of the aforementioned active agents is administered to a subject.

Abstract: The present invention concerns the use of selected compounds in a cosmetic skincare treatment or in the treatment of certain skin, scalp or mucosal diseases. The invention also provides a composition for topical use incorporating a pharmaceutically or cosmetically effective amount of a compound for preventing or treating skin or mucosal diseases having an inflammatory component or for reducing the redness or irritation of skin or mucosae.

Abstract: An active agent for use in hair growth regulation, particularly for use in the treatment of hair growth (stimulation or inhibition), wherein the active agent activates, enhances, inactivates, blocks or dampens the cellular response of the taste receptor TAS2R4 or interferes with the expression of the receptor. Furthermore, the present invention is directed to compositions for use as a cosmetic or medicament in the treatment of hair growth the composition comprising at least one of the aforementioned active agents and at least one auxiliary agent. In addition, a non-therapeutic method of hair growth regulation is disclosed, wherein an effective amount of at least one of the aforementioned active agents is administered to a subject.

Abstract: The invention relates to a synergistic composition comprising a dry extract of plant of genus Galeopsis and a compound promoting autophagy selected from biotin and R-N1-spermidine or a salt thereof, wherein R is hydrogen or methyl and mixtures thereof. The synergistic compositions according to the invention may be in the form of a topical formulation or oral formulation and is useful as a promoter of autophagy especially in cells of human scalp hair follicles and in promoting hair growth and/or in the treatment of hair thinning or hair loss.

Abstract: The present invention concerns the use of selected compounds in a cosmetic skincare treatment or in the treatment of certain skin, scalp or mucosal diseases. The invention also provides a composition for topical use incorporating a pharmaceutically or cosmetically effective amount of a compound for preventing or treating skin or mucosal diseases having an inflammatory component or for reducing the redness or irritation of skin or mucosae.

Abstract: The invention relates to a synergistic composition comprising a dry extract of plant of genus Galeopsis and a compound promoting autophagy selected from biotin and R-N1-spermidine or a salt thereof, wherein R is hydrogen or methyl and mixtures thereof. The synergistic compositions according to the invention may be in the form of a topical formulation or oral formulation and is useful as a promoter of autophagy especially in cells of human scalp hair follicles and in promoting hair growth and/or in the treatment of hair thinning or hair loss.

Abstract: Provided herein are methods for enhancing epidermal regeneration in a patient in need thereof, comprising topically administering to said patient a pharmaceutically acceptable composition comprising N-acetyl-3-(4-aminophenyl)-2-methoxypropionic acid or a pharmaceutically acceptable salt or stereoisomer thereof, and a pharmaceutically acceptable excipient. For example, provided are methods for treating or ameliorating cicatricial alopecia, comprising topically administering to a patient in need thereof a pharmaceutically acceptable composition comprising the disclosed compounds. Also provided are methods for protecting hair follicle progenitor cells and compositions comprising same using the disclosed compounds.

Abstract: The invention concerns the use of compounds of general formula (I): (I) wherein: R1 and R2 form together a double bond, or R1 and R2 form together a cyclopropyl group; R3, R4 are the same or different and independently chosen from hydrogen, methyl, or R3 and R4 form together a double bond; R5, R6 are the same or different and independently chosen from hydrogen, methyl; or R5 and R6 form together a double bond, or R5 and R6 form together a cyclopropyl group; R7=methyl, or ethyl; R8=hydrogen, or methyl, for promoting hair growth and/or inhibiting or delaying hair loss in the human scalp, and cosmetic and pharmaceutical compositions suitable for such use.

Abstract: The present invention relates to the use of iminooxothiazolidine derivatives for preventing or treating hair growth disorders. The iminooxothiazolidine derivatives may be formulated as compositions suitable for either the systemic administration or the local application to the scalp.

Abstract: The invention concerns the use of compounds of general formula (I): (I) wherein: R1 and R2 form together a double bond, or R1 and R2 form together a cyclopropyl group; R3, R4 are the same or different and independently chosen from hydrogen, methyl, or R3 and R4 form together a double bond; R5, R6 are the same or different and independently chosen from hydrogen, methyl; or R5 and R6 form together a double bond, or R5 and R6 form together a cyclopropyl group; R7=methyl, or ethyl; R8=hydrogen, or methyl, for promoting hair growth and/or inhibiting or delaying hair loss in the human scalp, and cosmetic and pharmaceutical compositions suitable for such use.

Abstract: The present invention provides cosmetic and pharmaceutical compositions and therapies capable of reducing skin pigmentation and valuable in treating and managing disorders of skin pigmentation. The invention uses safe and well tolerated non-digestible oligosaccharides as the active agents providing numerous advantages over the harsh chemicals of previously available compositions.

Abstract: The invention concerns the use of compounds with formula (I) R—N1-spermidine, or 1,4-butandiamin,N-(3-amino propyl)-N1-R, (I) H2N—(CH2)3—N1(R)—(CH2)4—NH2 either as such or in the form of a pharmaceutically acceptable derivative, such as an active ingredient in a cosmetic composition designed to promote hair pigmentation, particularly the pigmentation of the shaft, and a composition suitable to achieve said pigmentation effect and containing said active ingredient, either as such or in the form of a pharmaceutically acceptable derivative such as a salt, for topical administration.

Abstract: The present invention provides a composition for inhibiting hair production in a mammal comprising an active polypeptide component and a pharmaceutically acceptable and/or cosmetically acceptable excipient, carrier or diluent. The invention further provides methods of inhibiting hair production in a mammal, e.g. human.

Abstract: The invention concerns the use of compounds with formula (I) R—N1-spermidine, or 1,4-butandiamin,N-(3-amino propyl)-N1-R, (I) H2N—(CH2)3—N1(R)—(CH2)4—NH2 either as such or in the form of a pharmaceutically acceptable derivative, such as an active ingredient in a cosmetic composition designed to promote hair pigmentation, particularly the pigmentation of the shaft, and a composition suitable to achieve said pigmentation effect and containing said active ingredient, either as such or in the form of a pharmaceutically acceptable derivative such as a salt, for topical administration.

Abstract: The invention relates to the use of compounds of formula (I) R—N1-spermidine, i.e. 1.4-butanediamine,N-(3-aminopropyl)-N1—R, (I) H2N —(CH2)3—N1(R)—(CH2)4—NH2, as such or in the form of pharmaceutically acceptable derivatives, as active principle in a cosmetic or pharmaceutical composition for resisting the effects of skin ageing through an anti-inflammatory action, by topical administration. Such compounds also have an antioxidant activity against oxygen free radicals (ROS) comparable with that of ?-tocopherol.

Abstract: The invention concerns the use of compounds of formula (I) R-N1-spermidine, or 1,4-butandiamine,N-(3-amino propyl)-N1—R, (I) H2N—(CH2)3—N1 (R)—(CH2)4—NH2, as such or in the form of pharmaceutically acceptable derivatives, as the active principle in a pharmaceutical or cosmetic composition to preserve and protect epithelial stem cells, and progenitor cells that derive from them, through topical application on the skin or through the use of compounds in cell cultures. Hence, the invention especially concerns the use of compounds of formula (I) to treat cicatricial alopecia, and to stimulate and accelerate tissue repair and healing of both wounds and epidermal scars.

Abstract: The present invention relates to a cosmetic or pharmaceutical composition for treating alopecia, and in general for counteracting excessive hair loss, comprising as an active ingredient a compound of formula (I) R—N1-spermidine, or 1,4-butane-diamine,N-(3-aminopropyl)-N1—R. The compounds of general formula (I) are active in accordance with the objects of the present invention, and also sufficiently stable to allow effective application for topical use on the scalp without potentially being transformed into a different substance, which is no longer active, as a result of oxidation.

Abstract: The invention concerns the use of compounds with formula (I) R—N1-spermidine, or 1,4-butandiamin,N-(3-amino propyl)-N1-R, (I) H2N—(CH2)3—N1(R)—(CH2)4—NH2 either as such or in the form of a pharmaceutically acceptable derivative, such as an active ingredient in a cosmetic composition designed to promote hair pigmentation, particularly the pigmentation of the shaft, and a composition suitable to achieve said pigmentation effect and containing said active ingredient, either as such or in the form of a pharmaceutically acceptable derivative such as a salt, for topical administration.

Abstract: The present invention relates to compounds having general formula (I): CH3—(CH?CH)n—R??(I) where: n=3, 5, 7; R is chosen from —CH2—O—CO—R?, —CO—OR? or —CO—O(?), R? is chosen from H, C1-C22 alkyl or alkenyl, aryl or aralkyl, or sugars; and their pharmaceutically acceptable salts, such as sodium, potassium and lysine salts, for use as the active ingredient in pharmaceutical or cosmetic compositions for improving the pigmentation of the human skin, treating pigmentation disorders and/or improve both the photoprotective capacity of the skin and the intensity of its suntan.