Abstract: A spectrometer device includes an optical interference filter which is designed to filter specific wavelength ranges of an incident light beam on passage through the optical interference filter. The spectrometer device also includes a detector device which is designed to detect the filtered light beam. Further, the spectrometer device includes a focusing device with a reflective surface. The focusing device is designed to focus the filtered light beam onto the detector device by reflection on the surface.

Abstract: A rAAV having a vector genome with a UBE3A coding sequence is provided. Also provided is a method for treating one or more symptoms of Angelman syndrome (AS) in a patient having deficient UBE3A expression in neurons, wherein the method comprises delivering a rAAV having a nucleic acid sequence which encodes UBE3A.

Abstract: A composition comprising an expression cassette having a nucleic acid sequence encoding one or more elements of a gene editing system that targets UBE3A-ATS on a paternal allele in a neuron of a patient having Angelman syndrome is provided. Also provided is a method for treating one or more symptoms of Angelman syndrome (AS) in a patient having deficient UBE3A expression in neurons, wherein the method comprises delivering a nucleic acid sequence that encodes one or more elements of a gene editing system that targets UBE3A-ATS to modify the UBE3A-ATS coding sequence and provide for expression of paternal UBE3A.

Abstract: Provided is a recombinant adeno-associated virus (rAAV) having an AAV capsid and a vector genome which comprises a nucleic acid sequence encoding a functional CDKL5 (hCDKLK5). Also provided are a production system useful for producing the rAAV, a pharmaceutical composition comprising the rAAV, and a method of treating a subject having CDD, or ameliorating symptoms of CDD, or delaying progression of CDD via administrating an effective amount of the rAAV to a subject in need thereof.

Abstract: An electric motor and inverter assembly (100) used in an electric vehicle or a hybrid electric vehicle to drive the vehicle's wheels to rotate is disclosed. The electric motor and inverter assembly comprises: an electric motor (300), which includes a housing including a main shell (310), an end cover (320) and a connecting cover (330), wherein a cooling passage is formed in a wall of the housing such that coolant is able to flow in the cooling passage, and an end cover (320) and a connecting cover (330) are respectively connected to opposite ends of the main shell; and an inverter, which includes a housing (210) in which a power element and/or an electrical device is received, wherein the housing of the inverter contacts the connecting cover such that an interface is defined between the connecting cover and the housing of the inverter, and the coolant flowing through the cooling passage is able to contact the interface.

Abstract: A charged particle beam device for irradiating or inspecting a specimen is described. The charged particle beam device includes a charged particle beam source for generating a primary charged particle beam and a multi-aperture lens plate having a plurality of apertures for forming four or more primary. Two or more electrodes having one opening, e.g. having one opening each, for the primary charged particle beam or the four or more primary beamlets are provided. The charged particle beam device further includes a collimator for deflecting a first primary beamlet, a second primary beamlet, a third primary beamlet, and a fourth primary beamlet of the four or more primary beamlets with respect to each other. The charged particle beam device further includes an objective lens unit having three or more electrodes, each electrode having openings for the four or more primary beamlets.

Abstract: Provided is a recombinant adeno-associated virus (rAAV) having an AAV capsid and a vector genome which comprises a nucleic acid sequence encoding a functional human methyl-CpG-binding protein 2 (hMECP2). Also provided is a production system useful for producing the rAAV, a pharmaceutical composition comprising the rAAV, and a method of treating a subject having Rett Syndrome, or ameliorating symptoms of Rett Syndrome, or delaying progression of Rett Syndrome via administrating an effective amount of the rAAV to a subject in need thereof.

Abstract: An electric motor and inverter assembly (100) used in an electric vehicle or a hybrid electric vehicle to drive the vehicle's wheels to rotate is disclosed. The electric motor and inverter assembly comprises: an electric motor (300), which includes a housing including a main shell (310), an end cover (320) and a connecting cover (330), wherein a cooling passage is formed in a wall of the housing such that coolant is able to flow in the cooling passage, and an end cover (320) and a connecting cover (330) are respectively connected to opposite ends of the main shell; and an inverter, which includes a housing (210) in which a power element and/or an electrical device is received, wherein the housing of the inverter contacts the connecting cover such that an interface is defined between the connecting cover and the housing of the inverter, and the coolant flowing through the cooling passage is able to contact the interface.

Abstract: A method of operating a charged particle beam device is disclosed, including passing each of a plurality of beamlets through a deflector and a scanner, in that order. Each of the beamlets is focused with an objective lens on a sample to form a plurality of focal spots, forming an array. A first beamlet is focused on a first spot and a second beamlet is focused on a second spot. In a centered configuration of the device, each of the plurality of beamlets is directed by the deflector toward a coma free point. In a beamlet-displaced configuration of the device, the scanner is scanned such that the first beamlet passes through an acceptable aberrations point, the first beamlet scanning a displaced first field of view; and the first spot is displaced from the regular first focal spot to a displaced first focal spot.

Abstract: A method of operating a charged particle beam device is disclosed, including passing each of a plurality of beamlets through a deflector and a scanner, in that order. Each of the beamlets is focused with an objective lens on a sample to form a plurality of focal spots, forming an array. A first beamlet is focused on a first spot and a second beamlet is focused on a second spot. In a centered configuration of the device, each of the plurality of beamlets is directed by the deflector toward a coma free point. In a beamlet-displaced configuration of the device, the scanner is scanned such that the first beamlet passes through an acceptable aberrations point, the first beamlet scanning a displaced first field of view; and the first spot is displaced from the regular first focal spot to a displaced first focal spot.

Abstract: A front module (7) of a motor vehicle has vehicle front-side air guiding element (1) for a vehicle radiator, and has a foam crash element (6) that is positioned in front of the air guiding element (1) on the front side. The air guiding element (1) is fastened to the foam crash element (6) at least in a part region. The front module ensures particularly satisfactory dimensional and positional stabilization of the air guiding element (1).

Abstract: A front module (7) of a motor vehicle has vehicle front-side air guiding element (1) for a vehicle radiator, and has a foam crash element (6) that is positioned in front of the air guiding element (1) on the front side. The air guiding element (1) is fastened to the foam crash element (6) at least in a part region. The front module ensures particularly satisfactory dimensional and positional stabilization of the air guiding element (1).

Abstract: A device for the reinforcement of large-surface-area lateral sections of a rear bumper covering is effected by a supporting holder which is arranged pivotably on a load-bearing structure, is folded-in in a delivery position, is folded up in an assembly position and can be fastened with its free end to the vehicle body.

Abstract: The present invention relates to a device for testing an optoelectronic module, comprising a first source for generating an electromagnetic beam or particle beam, a second source for illuminating the optoelectronic module; and a detector. In addition, a method for testing an optoelectronic module is provided comprising illuminating the optoelectronic module, directing an electromagnetic beam or particle beam and detecting defects in the optoelectronic module. The illumination additional to the electromagnetic beam or particle beam makes defects visible which otherwise would not be detected.

Abstract: A crash apparatus, in particular a crash box in a motor vehicle, has a deformation body for absorbing energy in the event of a crash, which body is assembled from two half shells having beads running transversely to the main deformation direction. The two half shells each have outwardly projecting flanges with beads also running transversely to the main deformation direction. The two half shells exclusively press against one another via the contact surfaces lying between the beads of the flanges and are connected to one another in these areas.

Abstract: The invention relates to a method of calibration of the beam position of a corpuscular beam. A calibration body with structures is used, wherein the structures have a structure period PS in the plain section and within each structure there is a position L intended for the measurement. For the calibration, at least one detection signal each at structures in the plain section of the calibration body is generated, wherein the corpuscular beam is deflected with deflectors on beam target positions L1 with the beam target period P1, which is larger than half of the structure period PS, whereby a basic calibration is used for the control of the deflectors, and wherein the beam target deflections deviate either in the beam target period P1 from the structure period PS and/or in the beam target position L1 from the position L.

Abstract: A method for testing a plurality of electronic devices formed on a large area substrate is described. In one embodiment, the method includes transferring a substrate on an end effector relative to a testing platform having a plurality of testing columns coupled thereto, the substrate having a plurality of electronic devices located thereon, and moving the substrate in a single directional axis relative to an optical axis of each of the plurality of testing columns, the single directional axis being substantially orthogonal to the optical axis to define a test area on the substrate, wherein the test area is configured to cover an entire length or an entire width of the substrate such that the testing columns are capable of testing the entire substrate as the substrate is moved through the test area.

Abstract: A method and apparatus for testing a plurality of electronic devices formed on a large area substrate is described. In one embodiment, the apparatus performs a test on the substrate in one linear axis in at least one chamber that is slightly wider than a dimension of the substrate to be tested. Clean room space and process time is minimized due to the smaller dimensions and volume of the system.

Abstract: A method of testing electronic devices on substrates is described. The method includes placing a configurable prober over a first substrate, testing the first substrate, re-configuring the configurable prober, placing the configurable prober over a second substrate, and testing the second substrate.

Abstract: An apparatus and method for testing large area substrates is described. The large area substrates include patterns of displays and contact points electrically coupled to the displays on the large area substrate. The apparatus includes a prober assembly that is movable relative to the large area substrate and/or the contact points, and may be configured to test various patterns of displays and contact points on various large area substrates. The prober assembly is also configured to test fractional sections of the large area substrate positioned on a testing table, and the prober assembly may be configured for different display and contact point patterns without removing the prober assembly from the testing table.