Abstract: An ultrasonic diagnostic imaging system is described which can diagnose, treat, or monitor the cranial vasculature for obstructions such as blood clots causing ischemic stroke. The system has a headset which maintains two transducer arrays in contact with acoustic windows through the temporal bones on opposite sides of the head. The clinician is aided in properly positioning the arrays over the best acoustic windows through the bone by a signal produced by one of the arrays in response to transmission through the cranium by the other array, which passes through the temporal bones on both sides of the head. The amplitude of this through- transmission signal is detected and displayed to the clinician, either qualitatively or quantitatively, as the arrays are positioned.

Abstract: A head frame for a medical patient includes support for a probe and a neck support. The frame wraps around the head of the patient and can be used in the supine position. The support may include a probe holder slidable under the head and configured to contact or engage the neck support. In some embodiments, conformal shaping to the head and/or neck of the patient, the frame's rigid construction, the alignment of the optionally separable holder to the neck support, the weight of the head, or a combination thereof serve to keep the distal tip of the ultrasound probe in place against the temporal region of the head without need for attaching the frame to the head as by straps, which may provide an arrangement robust against patient/vehicle movement in an emergency medical services setting.

Abstract: An apparatus for patient-specific adjusting of ultrasound output pressure includes a controller (118) configured for adjusting, based on an estimate of thickness of a temporal bone (140) in a head of a medical treatment recipient, a pressure setting. It may also be based on treatment depth (134). Ultrasound at the adjusted pressure setting is applied. A user interface may be provided for user entry of the estimate, the user interface being further configured for user indication of the treatment depth. Both the entered estimate and the indicated treatment depth may be used in calculating ultrasound attenuation (148). The user indication can be interactive by virtue of designating, on a display, a location of a treatment target. The calculated attenuation may be a value, in decibels, that is in a range from 0.9×(2.70×0.1+16.60×T+0.87×(D?T?0.1)+3.02) to 1.1×(2.70×0.1+16.60×T+0.87×(D?T?0.1)+3.02), where T is the estimate in centimeters and D is the treatment depth in centimeters.

Abstract: A therapeutic ultrasound system transmits a staggered or interleaved pattern of therapy beams for use in sonothrombolysis and other Vascular Acoustic Resonators (VAR) mediated therapy. The inventive technique minimizes VAR, e.g. microbubble, destruction due to adjacent beams, ensures uniform sonication of the targeted region by filling in the spaces between the beams in subsequent passes, and further provides a means for bubble replenishment to maximize the clot lysis from ultrasound. The technique is also applicable to diagnostic ultrasound, VAR mediated drug delivery and blood brain barrier opening.

Abstract: A device for delivery of a substance (144) using energy to protect, at a site of activation, against a side effect of another substance (156) that was delivered, is being delivered, and/or will be delivered, at another site. The activation may be non-invasive, remote and the energy beam (140) may be an ultrasound beam. A first of the substances can be activated at a particular energy level, and the second is then activated at a lower level so that a population of particles bearing the first substance is not inadvertently activated during activation of the second substance. The device may comprise a system to control the levels of energy applied.

Abstract: An infusion system for sonothrombolysis treatment uses a syringe loaded with a microbubble solution and operated by a syringe pump to deliver the microbubble solution to a subject during sonothrombolysis treatment. To prevent the stratification of the microbubble solution in the barrel of the syringe during treatment, the barrel also contains a plurality of magnetic beads which are agitated into semi-random patterns of motion in the syringe chamber during the procedure. The magnetic beads are moved by magnetic attraction and repulsion from the moving magnets of a magnetic stirrer mounted in proximity to the syringe during treatment.

Abstract: A bolus assembly is configured to receive and be removably coupled to a transducer assembly of an ultrasound probe assembly. The bolus assembly includes a housing assembly and at least one sealing member. The housing assembly has a body having first and second ends, and a sidewall extending therebetween, the body forming a cavity defined by the first end, second end, and sidewall, the cavity being configured to receive at least one transducer of a transducer assembly, a first passage extending through the second end of the body, the sidewall including at least one opening spaced-apart from the passage; and an acoustically transparent and distensible membrane attached to an entire outer periphery of the opening. The sealing member has a through hole and is positioned within the passage. The through hole is configured to receive the shaft. The sealing member is sealingly engaged with the shaft within the passage.

Abstract: A fluid management system for use with an ultrasound probe assembly can include first and second conduits each configured to extend from and be fluidly connected to the ultrasound probe assembly. A fluid directing system can include a circulation pump fluidly connected to both the first and second conduits. A fluid degassing system can be fluidly connected to the first and second conduits. The fluid degassing system can be configured to remove at least some gas from the fluid in the ultrasound probe assembly. A temperature control system can be fluidly connected to the first and second conduits. The temperature control system can be configured to control the temperature of the fluid in the ultrasound probe assembly. A volume adjustment system can be fluidly connected to the first and second conduits. The volume adjustment system can be configured to adjust the volume of the fluid in the ultrasound probe assembly.

Abstract: An ultrasound delivery system can include a console assembly having a display and a computer system, and a positioning assembly operatively connected to the console assembly. The positioning assembly can be articulable between a plurality of different configurations upon receipt of one or more instructions from the computer system. The positioning assembly can include at least one gripper mechanism configured to selective grip and release. At least one probe assembly can include an ultrasound transducer assembly, a first bolus assembly and a second bolus assembly. The first bolus assembly can have at least a different geometry than the second bolus assembly. At least a portion of the ultrasound transducer assembly can be removably positionable within each of the first bolus assembly and the second bolus assembly. At least a portion of the probe assembly can be selectively connected to gripper mechanism and moved by the positioning assembly.

Abstract: A method for delivering ultrasound can include positioning at least a focal zone of a transducer of an ultrasound probe proximate to targeted tissue of a patient. The method can include supplying power to the transducer to deliver ultrasound energy from the transducer to a first portion of the targeted tissue for a predetermined amount of time to create a first focal lesion in the targeted tissue. The method can include at least temporarily ceasing power to the transducer so as to at least temporarily cease delivery of ultrasound energy from the transducer to the targeted tissue. The method can include supplying power to the transducer to deliver ultrasound energy from the transducer to the targeted tissue at least substantially continuously and along a predefined treatment path.

Abstract: A method of diagnosis and treatment of tumors using High Intensity Focused Ultrasound is provided. The method of diagnosing the presence of a tumor in a patient comprises the steps of subjecting a tumor to high intensity focused ultrasound (HIFU) to cause the tumor cells to release cellular material and evaluating the cellular material for a tumor marker. The method of treating a tumor in a patient can also comprise the step of subjecting a tumor to high intensity focused ultrasound (HIFU) to provoke an immune response.

Abstract: An ultrasonic diagnostic imaging system with a two dimensional array transducer performs microbubble-mediated therapy such as sonothrombolysis. The array is formed by dicing into rectilinear elements with the corner elements absent to provide a generally rounded shape that accommodates the temporal windows of the head for cranial therapeutic energy delivery. In several described implementations additional transducer elements are optimized for other specialized functions such as A-line imaging, Doppler flow detection, temporal bone thickness estimation, or cavitation detection. Preferably there are 128 therapeutic elements so that the array probe can be used with standard ultrasound systems having 128-channel beamformers.

Abstract: An ultrasonic intracranial sonothrombolysis pressure amplitude is pre-quantified by using an ultrasound-scanner control unit (110) having an increasing and/or decreasing mode and designed for: with respect to a current mode, interrogating a blockage site iteratively so as to progressively and respectively increase or decrease a pressure amplitude of ultrasound being emitted to the site at which bubbles (144) for oscillating that is caused by the emitted ultrasound are present; iteration to iteration, deriving, from echoes of the emitted ultrasound, a magnitude of an energy of a signal; and automatically identifying, for the quantifying, an iteration that, in comparison with a just-previous iteration, fails to increase the magnitude. The interrogating may span a region that contains or goes through: the obstruction; another part of the blood vessel; and bubble circulation within a neighboring vessel and a neighboring capillary (136).

Abstract: Bubble presence within a region is monitored to determine if a predetermined condition is met such as whether the presence is of sufficient magnitude, the bubbles being subject to energizing (240). In some embodiments, the energizing only occurs when time- wise preceded by the determination (S508, S510). The determining can include measuring a grayscale value (104), or assessing the energy carried by a frequency component of the echo signal, in the region in real time. The energizing may occur region-by-region, automatically and without need for user intervention, in a treatment pass (S428) over the regions. The regions (232) in the pass might be subject to respective instances of the energizing without intervening monitoring, or, in another embodiment, to both the determining and the responsive energizing. The determining can be subject to, automatically and without need for user intervention, interruption (S408) and concurrent switching to a next region.

Abstract: A method of harvesting a blood vessel, the method may be performed by an apparatus which may include a flexible body portion (102) having at least one ultrasound transducer (112), the apparatus may be controlled by at least one controller, the method may include one or more acts of: percutaneously situating the flexible body into the blood vessel having vessel walls and connective tissue attached to the vessel walls; and exciting the at least one ultrasound transducer (112) to output ultrasound signals of a first type having a focal zone outside of the vessel walls so as to fractionate a region of connective tissue in the focal zone.

Abstract: A method of performing a coronary bypass procedure, the method may be performed by the flexible apparatus controlled by at least one controller, the method may include acts of: percutaneously situating the flexible apparatus into a first artery coupled to connective tissue of a chest wall; transluminally detaching at least a portion of the first artery from the connective tissue by applying ultrasound signals of a first type emitted by at least one transducer of the flexible apparatus; steering at least a portion of the detached portion first artery from a current location to a bypass location at a target artery by applying a force transmitted through the flexible apparatus situated within the first artery; and coupling, by the flexible apparatus situated within the first artery, the first artery to the target artery at the bypass location to establish flow communication between the first artery and the target artery.

Abstract: A method of diagnosis and treatment of tumors using High Intensity Focused Ultrasound is provided. The method of diagnosing the presence of a tumor in a patient comprises the steps of subjecting a tumor to high intensity focused ultrasound (HIFU) to cause the tumor cells to release cellular material and evaluating the cellular material for a tumor marker. The method of treating a tumor in a patient can also comprise the step of subjecting a tumor to high intensity focused ultrasound (HIFU) to provoke an immune response.

Abstract: A system to perform a bypass procedure performed by an apparatus (100, 400, 600) comprising a steerable body portion (102, 450, 452) and at least one transducer (114, 414) controlled by at least one controller (610). The system may include one or more acts of transluminally detaching at least a portion of a first artery from connective tissue (423) of a chest wall (425) that is attached to the first artery by applying ultrasound signals of a first type emitted by the at least one transducer (114, 414) situated within in the first artery; steering the detached portion of the first artery from a current location to a bypass location by applying a force from the steerable body portion, which is located outside of the first artery, to at least a portion of the detached portion of the first artery; and coupling the first artery to a target artery at the bypass location to establish flow communication between the first artery and the target artery.

Abstract: A method and system for treating a target area of a patient, for example an area of the brain which includes an occlusion: employ an ultrasound imaging apparatus to produce an ultrasound image of a region of a subject; register the ultrasound image to a computed tomography (CT) image dataset; identify in the ultrasound image a location of a target area via a marker of the target area produced from the CT image dataset; verify the location of the target area with the ultrasound imaging apparatus; and provide sonothrombolysis treatment to the target area while monitoring the target area with the ultrasound imaging apparatus.

Abstract: A method of diagnosis and treatment of tumors using High Intensity Focused Ultrasound is provided. The method of diagnosing the presence of a tumor in a patient comprises the steps of subjecting a tumor to high intensity focused ultrasound (HIFU) to cause the tumor cells to release cellular material and evaluating the cellular material for a tumor marker. The method of treating a tumor in a patient can also comprise the step of subjecting a tumor to high intensity focused ultrasound (HIFU) to provoke an immune response.