Abstract: The present invention relates to fusion proteins targeted to the central nervous system (CNS) and its use for the treatment of lysosomal storage disorders (LSD).

Abstract: The present invention provides variants of human ?-Glucocerebrosidase protein.

Abstract: The invention relates to a device (1) for labeling individual products (2), comprising an advancing device (3) for transporting each product (2) in a transport direction (X), a label dispensing device (4) for dispensing a label, which can be removed from a material strip (5), from a discharge point (6) in a dispensing direction (S), and a label transporting device (7) with a movable label transporting means (8) for transporting the dispensed label (5) from a transfer region (9), where the dispensed label (5) is transferred to the label transporting mean (8), to a delivery point (10), where the label (5) is applied onto the respective product (2). The label transport means (8) has a surface (11) which is brought into contact with the label (5). The aim of the invention is to simplify the labeling of individual products (2) and apply the labels (5) as precisely as possible.

Abstract: A hollow filter element for inserting into a filter device for filtering air, in particular of an internal combustion engine of a motor vehicle, includes a filter material which is held on the end face by a planar surround in a sealed manner. The planar surround has at least one grip recess for handling the hollow filter element. A filter device having such a hollow filter element includes a housing having a housing base part and a housing cover. The housing cover has at least one pin which, upon correct installation of the hollow filter element in the housing base part and when the housing cover is placed on the housing base part, projects into the grip recess of the planar surround.

Abstract: A hollow filter element for inserting into a filter device for filtering air, in particular of an internal combustion engine of a motor vehicle, includes a filter material which is held on the end face by a planar surround in a sealed manner. The planar surround has at least one grip recess for handling the hollow filter element. A filter device having such a hollow filter element includes a housing having a housing base part and a housing cover. The housing cover has at least one pin which, upon correct installation of the hollow filter element in the housing base part and when the housing cover is placed on the housing base part, projects into the grip recess of the planar surround.

Abstract: An composition comprising: (A) a mixture comprising at least one (thio)phosphoric acid triamide according to the general formula (I) R1R2N—P(X)(NH2)2, wherein X is oxygen or sulfur; R1 is a C1 to C20 alkyl, C3 to C20 cycloalkyl, C6 to C20 aryl, or dialkylaminocarbonyl group; R2 is H, or R1 and R2 together with the nitrogen atom linking them define a 5- or 6-membered saturated or unsaturated heterocyclic radical, which optionally comprises 1 or 2 further heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur, and (C) at least one amine selected from the group consisting of (C1) a polymeric polyamine, and (C2) an amine containing not more than one amino group and at least three alkoxy- or hydroxy-substituted C2 to C12 alkyl groups R21, wherein at least one of the groups R21 is different to the other groups R21, and (C3) an amine containing not more than one amino group and at least two alkoxy- or hydroxy-substituted C2 to C12 alkyl groups R22, wherein at least one of the grou

Abstract: An composition comprising: (A) a mixture comprising at least one (thio)phosphoric acid triamide according to the general formula (I) R1R2N—P(X)(NH2)2, wherein X is oxygen or sulfur; R1 is a C1 to C20 alkyl, C3 to C20 cycloalkyl, C6 to C20 aryl, or dialkylaminocarbonyl group; R2 is H, or R1 and R2 together with the nitrogen atom linking them define a 5- or 6-membered saturated or unsaturated heterocyclic radical, which optionally comprises 1 or 2 further heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur, and (C) at least one amine selected from the group consisting of (C1) a polymeric polyamine, and (C2) an amine containing not more than one amino group and at least three alkoxy- or hydroxy-substituted C2 to C12 alkyl groups R21, wherein at least one of the groups R21 is different to the other groups R21, and (C3) an amine containing not more than one amino group and at least two alkoxy- or hydroxy-substituted C2 to C12 alkyl groups R22, wherein at least one of the groups R

Abstract: The invention relates to a device (1) for labeling individual products (2), comprising an advancing device (3) for transporting each product (2) in a transport direction (X), a label dispensing device (4) for dispensing a label, which can be removed from a material strip (5), from a discharge point (6) in a dispensing direction (S), and a label transporting device (7) with a movable label transporting means (8) for transporting the dispensed label (5) from a transfer region (9), where the dispensed label (5) is transferred to the label transporting mean (8), to a delivery point (10), where the label (5) is applied onto the respective product (2). The label transport means (8) has a surface (11) which is brought into contact with the label (5). The aim of the invention is to simplify the labeling of individual products (2) and apply the labels (5) as precisely as possible.

Abstract: An composition comprising: (A) a mixture comprising at least one (thio)phosphoric acid triamide according to the general formula (I) R1R2N—P(X)(NH2)2, wherein X is oxygen or sulfur; R1 is a C1 to C20 alkyl, C3 to C20 cycloalkyl, C6 to C20 aryl, or dialkylaminocarbonyl group; R2 is H, or R1 and R2 together with the nitrogen atom linking them define a 5- or 6-membered saturated or unsaturated heterocyclic radical, which optionally comprises 1 or 2 further heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur, and (C) at least one amine selected from the group consisting of (C1) a polymeric polyamine, and (C2) an amine containing not more than one amino group and at least three alkoxy- or hydroxy-substituted C2 to C12 alkyl groups R21, wherein at least one of the groups R21 is different to the other groups R21, and (C3) an amine containing not more than one amino group and at least two alkoxy- or hydroxy-substituted C2 to C12 alkyl groups R22, wherein at least one of the

Abstract: A SAW filter circuit having improved ESD resistance is specified, in which a series interconnection composed of SAW resonators is interconnected between a first signal port and a dual-mode SAW filter port. The static capacitance of the series interconnection is at most four times the static capacitance of the dual-mode SAW filter transducers interconnected therewith.

Abstract: A mixture for the treatment of urea-containing fertilizers comprises a) at least one (thio)phosphoric acid triamide of the general formula (I) R1R2N—P(X)(NH2)2 and/or (thio)phosphoric acid diamide of the general formula (II) R1O—P(X)(NH2)2, X denoting oxygen or sulfur, R1 and R2 independently from each other being hydrogen, substituted or unsubstituted 2-nitrophenyl, C1-10-alkyl, C3-10-cycloalkyl, C3-10-heterocycloalkyl, C6-10-aryl, C6-10-heteroaryl or diaminocarbonyl, where R1 and R2 together with the nitrogen atom connecting them can also form a 5 or 6-membered saturated or unsaturated heterocyclic group, which optionally may also comprise one or two additional heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur, as component A, and b) at least one compound comprising an amino group having a boiling point of more than 100° C. as component B.

Abstract: The present invention provides apo crystals and co-crystals of insulin-degrading enzyme (IDE) and their uses in drug development.

Abstract: A SAW filter circuit having improved ESD resistance is specified, in which a series interconnection composed of SAW resonators is interconnected between a first signal port and a DMS port. The static capacitance of the series interconnection is at most four times the static capacitance of the DMS transducers interconnected therewith.

Abstract: The invention relates to a bleach system comprising at least one component selected from bleach, bleach activator or bleach catalyst, wherein the bleach system is enveloped with at least one polymer layer and the polymer has urethane and urea groups. The inventive bleach system and detergent formulations comprising this bleach system are suitable for washing or cleaning textiles or dishware.

Abstract: The invention relates to preparations with improved urease-inhibitory effect which comprise at least two different (thio)phosphoric triamides and to urea-comprising fertilizers which comprise these preparations. The invention furthermore relates to a method of preparing these preparations, to the use of these preparations in the fertilization with urea-comprising fertilizers, and to the use of urea-comprising fertilizers which comprise these preparations in agriculture or in horticulture.

Abstract: A mixture for the treatment of urea-containing fertilizers comprises a) at least one (thio)phosphoric acid triamide of the general formula (I) R1R2N—P(X)(NH2)2 and/or (thio)phosphoric acid diamide of the general formula (II) R1O—P(X)(NH2)2, X denoting oxygen or sulfur, R1 and R2 independently from each other being hydrogen, substituted or unsubstituted 2-nitrophenyl, C1-10-alkyl, C3-10-cycloalkyl, C3-10-heterocycloalkyl, C6-10-aryl, C6-10-heteroaryl or diaminocarbonyl, where R1 and R2 together with the nitrogen atom connecting them can also form a 5 or 6-membered saturated or unsaturated heterocyclic group, which optionally may also comprise one or two additional heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur, as component A, and b) at least one compound comprising an amino group having a boiling point of more than 100° C. as component B.

Abstract: A sensor device includes a flexible first film that includes structured conductive traces. The sensor device also includes a probe electrically connected to the structured conductive traces. The probe is on a first surface of the first film and connected to the first surface of the first film. The sensor device also includes a flexible second film conformally surrounding the probe and sealing the probe to the first surface of first film.

Abstract: The present invention relates to co-crystals of Liver X receptor beta ligand binding domain (LXR?-LBD) with agonists and to the three-dimensional X-ray crystal structures derived thereof.

Abstract: The present invention provides apo crystals and co-crystals of insulin-degrading enzyme (IDE) and their uses in drug development.

Abstract: A sensor arrangement includes a tube, a measurement head and a holder. The measurement head includes a composite of at least two flexible plastic films and a sensing element arranged between the plastic films. The sensing element is electrically contacted via metallic conductor traces. The measurement head contacts a circumference of the tube and is arranged between the holder and the tube and is pressed by the holder onto the tube.