Abstract: The present invention relates to a particle collection for detecting a pathogen-neutralizing molecule. The present invention further relates to a composition comprising a particle collection. The present invention also relates to a method of detecting a pathogen-neutralizing molecule. Furthermore, the present invention relates to a kit for detecting a pathogen-neutralizing molecule. The present invention further relates to a point-of-care device, and to a use of a particle collection or a composition in a method of detecting a pathogen-neutralizing molecule.

Abstract: Methods for identifying optimized antigenic pathogen polypeptides capable of inducing a broadly neutralizing immune response, and associated T-cell responses, to a pathogen are described, as well as nucleic acid sequences encoding such polypeptides. Methods for determining whether a broadly neutralizing immune response is induced in a subject following immunization with an optimized antigenic pathogen polypeptide, or a nucleic acid encoding the optimized pathogen polypeptide, are also described. Nucleic acid molecules, polypeptides, vectors, cells, fusion proteins, pharmaceutical compositions, and their use as vaccines against pathogens, especially against emerging or re-emerging pathogens (particularly RNA viruses), are also described.

Abstract: The invention relates to nucleic acid modifications for a directed expression modulation by the targeted insertion or removal of CpG dinucleotides. The invention also relates to modified nucleic acids and expression vectors.

Abstract: The disclosure relates to an electrolyte for an energy store comprising a conducting salt and a solvent. The solvent comprises at least one compound according to the general formula (1), as indicated in the following: wherein R1, R2, R3, R4 are, identically or independently of each other, selected from the group comprising linear or branched C1-6-alkyl, C2-6-alkenyl C3-6-cycloalkyl and/or phenyl, each unsubstituted or mono- or polysubstituted by a substituent selected from the group comprising F, CN and/or C1-2-alkyl, mono- or polysubstituted with fluorine.

Abstract: The invention relates to the use of compounds according to general formula (1), in particular 1,4,2-dioxoazol-5-on-derivatives, as additives in electrolytes for electrochemical energy sources such as lithium-ion-batteries, and compounds containing electrolytes according to general formula (1), in particular 1,4,2-dioxoazol-5-on-derivatives.

Abstract: A counter bearing for machining spindles of machine tools has at least one expansion bushing with an elastically deformable wall that delimits at least one pressure chamber. The pressure chamber accommodates a pressure medium. A supply line for the pressure medium opens into the pressure chamber. A pressure conduit opens into the pressure chamber. A mechanically actuatable pressure element is disposed in the pressure conduit and actuated by an actuating tool. A piston is slidably arranged in the pressure conduit and actuated by the pressure element, wherein the piston loads the pressure medium.

Abstract: The invention relates to the use of compounds according to general formula (1), in particular 1,4,2-dioxoazol-5-on-derivatives, as additives in electrolytes for electrochemical energy sources such as lithium-ion-batteries, and compounds containing electrolytes according to general formula (1), in particular, 1,4,2-dioxoazol-5-on-derivatives.

Abstract: In monitoring the machine space of a processing machine during the throughput of workpieces in order to detect workpieces that got stuck, the rear end of a workpiece with reference to the transport direction generates a start signal in the inlet region of the machine space, as well as an end signal in the outlet region thereof by sensors that are connected to a control unit. Beginning with the start signal, the control unit detects a feature that characterizes a theoretical feed travel and generates a release signal if the value of the detected characteristic feature has reached at the time, at which the end signal is generated, a predefined limiting value and not yet exceeded a predefined upper limiting value or if the end signal is generated at a time, at which the value of the detected characteristic feature has reached the predefined limiting value and not yet exceeded the upper limiting value.

Abstract: A clamping device for an adjustable stop of a processing machine for guiding workpieces through the processing machine is provided with at least one clamping part that clamps the stop against at least one counter stop. The clamping part is provided on a transmission element, wherein the transmission element is acted upon with a force (F1) that is converted into a clamping force (F2) acting upon the clamping part. A release unit is provided for releasing the clamping action. The transmission element is a two-armed lever, one arm of which is acted upon with the force (F1) in the form of a compressive force and the other arm of which generates the clamping force (F2).

Abstract: A pressing device for a machine tool for processing or machining workpieces made of wood or plastics is provided with at least one support with a counter wedge surface. At least one pressing element is fastened to the at least one support. At least one wedge clamping device is provided that has at least one wedge pressure member with a first wedge surface that is resting on the counter wedge surface of the at least one support. The at least one wedge clamping device also has at least one adjusting element acting on the at least one wedge pressure member. The at least one wedge clamping device clamps the at least one pressing element on the at least one support. A machine tool with such a pressing device is provided.

Abstract: The invention relates to nucleic acid modifications for a directed expression modulation by the targeted insertion or removal of CpG dinucleotides. The invention also relates to modified nucleic acids and expression vectors.

Abstract: An electrolyte for a lithium-ion battery which includes lithium hexafluorophosphate and lithium 2-pentafluoroethoxy-1,1,2,2-tetrafluoroethanesulfonate. A lithium-ion battery which includes an electrolyte containing lithium hexafluorophosphate and lithium 2-pentafluoroethoxy-1,1,2,2-tetrafluoroethanesulfonate. A motor vehicle which uses a lithium-ion battery having electrolytes containing lithium hexafluorophosphate and lithium 2-pentafluoroethoxy-1,1,2,2-tetrafluoroethanesulfonate. The electrolyte can increase the service life of the lithium-ion battery.

Abstract: An alkali metal-based energy storage system, having at least one composite electrode containing an active material, and an electrolyte containing a lithium salt dissolved in an aprotic organic solvent, an ionic fluid and/or a polymer matrix. The electrolyte further contains an additive selected from a cation or a compound of a metal selected from Mg, Al, Cu and/or Cr. The metal selected from Mg, Al, Cu and/or Cr is applied onto the active material and/or the active material of the composite electrode is partially replaced by the metal selected from Mg, Al, Cu and/or Cr in the form of a metal powder or a metal salt.

Abstract: The invention relates to nucleic acid modifications for a directed expression modulation by the targeted insertion or removal of CpG dinucleotides. The invention also relates to modified nucleic acids and expression vectors.

Abstract: The clamping device is provided for tools and has a coupling piece that is provided with at least one actuating unit. The coupling piece acts to actuate a nut seated on a spindle journal that is receiving the tool. A torque coupling is provided for the nut. The coupling piece is fixedly connected with an output shaft that is in drive connection with a drive shaft by a transmission gear. As a result of the transmission gear, it is possible to rotate the drive shaft with minimal moment in order to apply the great clamping force required for axial clamping of the tool.

Abstract: A belt pulley arrangement for a belt drive for driving auxiliary units of a motor vehicle, comprising a belt pulley for introducing a torque that can be supplied by a traction mechanism, an output shaft for driving an auxiliary unit, particularly a coolant pump, an electric machine for transmitting torque between the belt pulley and the output shaft, the electric machine including a rotor connected to the belt pulley and a stator connected to the output shaft, and being able to be electrically connected to an electric energy source for the purpose of accelerating the output shaft and/or to an electric energy sink in order to decelerate the output shaft, a first rotational speed measurement device for detecting the time curve of the rotational speed of the belt pulley and/or a second rotational speed measurement device for detecting the time curve of the rotational speed of the output shaft, and a control device connected to the electric energy source and/or electric energy sink so as to control an output shaf

Abstract: A counter bearing for machining spindles of machine tools has at least one expansion bushing with an elastically deformable wall that delimits at least one pressure chamber. The pressure chamber accommodates a pressure medium. A supply line for the pressure medium opens into the pressure chamber. A pressure conduit opens into the pressure chamber. A mechanically actuatable pressure element is disposed in the pressure conduit and actuated by an actuating tool. A piston is slidably arranged in the pressure conduit and actuated by the pressure element, wherein the piston loads the pressure medium.

Abstract: A roller device for a traction mechanism drive of a motor vehicle, with a roller element for introducing a torque provided via the traction mechanism and a driven shaft for driving an auxiliary unit. The roller device has a magnetic coupling for non-positive torque transfer between the roller element and the driven shaft. The magnetic coupling has a primary-side unit connected to the roller element with a primary magnetic element and a secondary-side unit connected to the driven shaft with a secondary-side magnetic element. The magnetic elements are permanent and/or electromagnetic elements. The non-positive torque transfer is realized by magnetic fields of the primary-side and secondary-side magnetic elements. At least one magnetic element of the two units for changing the magnetic field overlap of the magnetic fields of the primary-side and secondary-side magnetic elements is movably arranged within its unit. A corresponding traction mechanism drive and method are provided.

Abstract: The adjusting device for a pressure roller of a processing machine has a pivotable support arm carrying a pressure roller adjustable with the support arm from a pressure position into a resting position. The support arm is seated on a support rod that engages a clamping aperture of a pressure roller bracket. The support rod has a first section with noncircular cross section that forms a form-fit section cooperating with the clamping aperture of the pressure roller bracket by form-fit. The support rod has a second section arranged axially offset to the first section and forming a rotary section. It rests against the inner side of the clamping aperture and allows rotation of the support rod about its axis in the clamping aperture. The pressure roller can be pivoted easily into a resting position and/or transverse to the workpiece in the width direction with a constructively simple design.

Abstract: A belt pulley arrangement for a belt drive to drive auxiliary units of a motor vehicle, having a belt pulley for introducing a torque that can be provided via a flexible drive means, an output shaft for driving an auxiliary unit, in particular a cooling water pump, and an electric machine for the transmission of torque between the belt pulley and the output shaft, wherein the electric machine has a rotor connected to the belt pulley and a stator connected to the output shaft. As a result of the power flow between the belt pulley and the output shaft, which can be influenced by the electric machine, it is not necessary to design the auxiliary unit that is attached via the output shaft for the least beneficial operating point, so that the auxiliary unit can be dimensioned smaller and a reduction in the installation space for motor vehicle components, in particular the installation space for auxiliary units of a motor vehicle that can be driven via the belt drive, is made possible.