Patents by Inventor Ralf Zimmermann

Ralf Zimmermann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11923182
    Abstract: Devices and methods for mass spectroscopic analysis of particles are disclosed herein. An example device includes: a first irradiation unit configured to irradiate a particle with electromagnetic radiation to cause components of the particle to detach from the particle. The example device further includes a second irradiation unit configured to irradiate substantially simultaneously i) at least a part of the detached components, and optionally a residual core of the particle, with a first beam of electromagnetic radiation the first beam of electromagnetic radiation exhibiting a first intensity, and ii) at least a part of the residual core, of the particle with a second beam of electromagnetic radiation. The second beam of electromagnetic radiation exhibiting a second intensity, which is preferably larger than the first intensity. The example device further includes a mass spectrometer comprising an ion source region, a first detection channel, and optionally a second detection channel.
    Type: Grant
    Filed: April 8, 2019
    Date of Patent: March 5, 2024
    Assignee: Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (GMBH)
    Inventors: Ralf Zimmermann, Johannes Passig, Sven Ehlert
  • Patent number: 11287402
    Abstract: An analytical system including a mass spectrometer (MS) coupled to liquid chromatography (LC) via an ionization source (IS), and an automated method of maintaining the analytical system in a QC-compliant status are described. The method comprises determining a deviation of the analytical system from a QC-compliant status by determining a deviation of one or more predetermined parameters in an m/z spectrum above one or more predetermined thresholds, triggering an IS and/or MS maintenance procedure upon determining a deviation from the QC-compliant status, determining a return or a failed return to the QC-compliant status during and/or after the IS and/or MS maintenance procedure by determining a return or a failed return respectively of the one or more predetermined parameters in an m/z spectrum below the one or more predetermined thresholds, triggering another IS and/or MS maintenance procedure upon determining a failed return to the QC-compliant status.
    Type: Grant
    Filed: December 7, 2020
    Date of Patent: March 29, 2022
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Stefan Quint, Marian Roetzer, Florian Schweinberger, Benjamin Tiemann, Marius Wagner, Ralf Zimmermann
  • Publication number: 20210181166
    Abstract: An analytical system including a mass spectrometer (MS) coupled to liquid chromatography (LC) via an ionization source (IS), and an automated method of maintaining the analytical system in a QC-compliant status are described. The method comprises determining a deviation of the analytical system from a QC-compliant status by determining a deviation of one or more predetermined parameters in an m/z spectrum above one or more predetermined thresholds, triggering an IS and/or MS maintenance procedure upon determining a deviation from the QC-compliant status, determining a return or a failed return to the QC-compliant status during and/or after the IS and/or MS maintenance procedure by determining a return or a failed return respectively of the one or more predetermined parameters in an m/z spectrum below the one or more predetermined thresholds, triggering another IS and/or MS maintenance procedure upon determining a failed return to the QC-compliant status.
    Type: Application
    Filed: December 7, 2020
    Publication date: June 17, 2021
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Stefan Quint, Marian Roetzer, Florian Schweinberger, Benjamin Tiemann, Marius Wagner, Ralf Zimmermann
  • Publication number: 20210134574
    Abstract: The invention relates to a device and a corresponding method for mass spectroscopic analysis of particles, the device comprising: a first irradiation unit (4) configured to irradiate a particle (1) with electromagnetic radiation to cause components of the particle (1) to detach, in particular to desorb, ablate and/or evaporate, from the particle (1), the detached components (2) of the particle (1) being located in proximity of a residual core (3) of the particle (1), a second irradiation unit (14-16, 19) configured to irradiate substantially simultaneously i) at least a part of the detached components (2), and optionally the residual core (3) of the particle (1), with a first beam (17) of electromagnetic radiation to cause an ionization of at least a part of the detached components (2), the first beam (17) of electromagnetic radiation exhibiting a first intensity, and ii) at least a part of the residual core (3) of the particle (1) with a second beam (18) of electromagnetic radiation to cause an ionization of
    Type: Application
    Filed: April 8, 2019
    Publication date: May 6, 2021
    Inventors: Ralf Zimmermann, Johannes Passig, Sven Ehlert
  • Patent number: 9942833
    Abstract: A mobile terminal device includes a radio processing circuit and a baseband processing circuit adapted to interact with the radio processing circuit. The mobile terminal device is configured to detect network access points on one or more carrier channels using a first radio scan and a second radio scan by obtaining one or more scan results of the first radio scan, each of the scan results of the first radio scan corresponding to a carrier channel targeted for radio scan by the first radio scan, identifying one or more selected scan results from the one or more scan results of the first radio scan, each of the one or more selected scan results of the first radio scan corresponding to a carrier channel targeted for radio scan by the second radio scan, and selecting the one or more selected scan results of the first radio scan as scan results of the second radio scan, and performing mobile communications using the scan results of the first radio scan or the scan results of the second radio scan.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: April 10, 2018
    Assignee: Intel IP Corporation
    Inventors: Sheetal Bhasin, Bent Rysgaard, Abhishek Raj, Prasanna Prabhakaran, Bernd Kemmer, Ralf Zimmermann, Karl-Heinz Rathgeb, Henrik Dalsgaard, Nirlesh Koshta, Manish Gupta
  • Publication number: 20170094589
    Abstract: A mobile terminal device includes a radio processing circuit and a baseband processing circuit adapted to interact with the radio processing circuit. The mobile terminal device is configured to detect network access points on one or more carrier channels using a first radio scan and a second radio scan by obtaining one or more scan results of the first radio scan, each of the scan results of the first radio scan corresponding to a carrier channel targeted for radio scan by the first radio scan, identifying one or more selected scan results from the one or more scan results of the first radio scan, each of the one or more selected scan results of the first radio scan corresponding to a carrier channel targeted for radio scan by the second radio scan, and selecting the one or more selected scan results of the first radio scan as scan results of the second radio scan, and performing mobile communications using the scan results of the first radio scan or the scan results of the second radio scan.
    Type: Application
    Filed: September 25, 2015
    Publication date: March 30, 2017
    Inventors: SHEETAL BHASIN, BENT RYSGAARD, ABHISHEK RAJ, PRASANNA PRABHAKARAN, BERND KEMMER, RALF ZIMMERMANN, KARL-HEINZ RATHGEB, HENRIK DALSGAARD, NIRLESH KOSHTA, MANISH GUPTA
  • Patent number: 8431889
    Abstract: The present invention relates to a method for repetitive chemical analysis of a gas flow, wherein said gas flow consists of a carrier gas and gaseous chemical compounds, comprising the following method steps: feeding said gas flow to a gas chromatographic separation column by means of a feeding device; collecting at least a part of said gaseous chemical compounds for a defined time period by means of a thermally based collecting device which is coupled to said gas chromatographic separation column and/or said feeding device; releasing said collected gaseous chemical compounds in a temporally focused manner by means of said thermally based collecting device; separating said released gaseous chemical compounds by means of said gas chromatographic separation column; and analyzing said separated gaseous chemical compounds by means of an analyzer. The present invention further relates to a device for performing such a method.
    Type: Grant
    Filed: March 19, 2012
    Date of Patent: April 30, 2013
    Assignee: Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt (GmbH)
    Inventors: Ralf Zimmermann, Mohammad Reza Saraji-Bozorgzad, Markus Simon Eschner, Thomas Maximilian Groeger
  • Publication number: 20120286154
    Abstract: The present invention relates to a method for repetitive chemical analysis of a gas flow, wherein said gas flow consists of a carrier gas and gaseous chemical compounds, comprising the following method steps: feeding said gas flow to a gas chromatographic separation column by means of a feeding device; collecting at least a part of said gaseous chemical compounds for a defined time period by means of a thermally based collecting device which is coupled to said gas chromatographic separation column and/or said feeding device; releasing said collected gaseous chemical compounds in a temporally focused manner by means of said thermally based collecting device; separating said released gaseous chemical compounds by means of said gas chromatographic separation column; and analyzing said separated gaseous chemical compounds by means of an analyzer. The present invention further relates to a device for performing such a method.
    Type: Application
    Filed: March 19, 2012
    Publication date: November 15, 2012
    Inventors: Ralf Zimmermann, Mohammad Reza Saraji-Bozorgzad, Markus Simon Eschner, Thomas Maximilian Groeger
  • Patent number: 7910883
    Abstract: A method for mass-spectrometric detection of compounds in a gas flow includes: alternatingly forming first and a second beams by switching between electron pulses/pulse trains and photon pulses/pulse trains, the photon pulses/pulse trains being generated by an excimer lamp, and the switching between the electron pulses/pulse trains and the photon pulses/pulse trains occurring at a switching frequency above 50 Hz; disposing the gas flow in an ionization region crossed by the first and second beams so as to ionize volume units in the gas flow so as to form ions of the compounds; deflecting the ions in an effective region of an electric field to a mass-spectrometric device; and sensing the ions with a mass-spectrometric process of the mass-spectrometric device.
    Type: Grant
    Filed: August 5, 2006
    Date of Patent: March 22, 2011
    Assignee: Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt (GmbH)
    Inventors: Fabian Muehlberger, Ralf Zimmermann
  • Publication number: 20090218482
    Abstract: A method for mass-spectrometric detection of compounds in a gas flow includes: alternatingly forming first and a second beams by switching between electron pulses/pulse trains and photon pulses/pulse trains, the photon pulses/pulse trains being generated by an excimer lamp, and the switching between the electron pulses/pulse trains and the photon pulses/pulse trains occurring at a switching frequency above 50 Hz; disposing the gas flow in an ionization region crossed by the first and second beams so as to ionize volume units in the gas flow so as to form ions of the compounds; deflecting the ions in an effective region of an electric field to a mass-spectrometric device; and sensing the ions with a mass-spectrometric process of the mass-spectrometric device.
    Type: Application
    Filed: August 5, 2006
    Publication date: September 3, 2009
    Applicant: GSF-Forschungszentrum fuer Umwelt und Gesundheit, GmbH
    Inventors: Fabian Muehlberger, Ralf Zimmermann
  • Publication number: 20090000873
    Abstract: A winterized turbocompressor unit has a turbocompressor and an oil supply installation for supplying the turbocompressor with a lubricating oil, the lubricating oil being a low-temperature oil and the turbocompressor and the oil supply installation being set up to be operated with the low-temperature oil.
    Type: Application
    Filed: June 24, 2008
    Publication date: January 1, 2009
    Inventors: Hans-Joachim Mollering, Norbert Stradmann, Ralf Zimmermann
  • Publication number: 20070051493
    Abstract: The invention relates to a heat exchanger (1) comprising fixing elements which are provided with points of fracture, in particular in a vehicle. The aim of said invention is to provide said heat exchanger with restorable points of fracture and to make it possible to easily reassemble them after the separation thereof. For this purpose, the inventive heat exchanger (1) is characterised in that at least one fixing element is provided with a first and second area (6, 7; 12, 14) and with a quick release coupling therebetween; two areas (6, 12) form an inseparable component of the heat exchanger (1); the two areas (6, 7; 12, 14) are fixable to each other by a positive connection when the quick release coupling is closed; the coupling systems of one of the areas (6, 7; 12, 14) are provided with at least one point of fracture and in that the coupling systems provided with at least one point of fracture are arranged on the area (7, 14) which a detachable from said heat exchanger.
    Type: Application
    Filed: April 5, 2004
    Publication date: March 8, 2007
    Inventors: Viorel Braic, Adolf Schembera, Dirk Becker, Stephan Bittner, Ralf Zimmermann
  • Publication number: 20070023606
    Abstract: A clamp actuator engages a moving jaw at one end of a sliding bar. A fixed jaw is immovably mounted in opposition to the moving jaw. A lever presses a drive gate against the bar to move it forward with each stroke of the lever. Clamping surfaces are vertically staggered and engage a tree trunk or similar workpiece to clamp it in place. The action is horizontal so as to avoid interference with workpiece elements above the clamp. The clamp may be established within a basin or bowl containing water so as to accommodate a Christmas tree.
    Type: Application
    Filed: July 27, 2005
    Publication date: February 1, 2007
    Inventor: Ralf Zimmermann
  • Patent number: 6772649
    Abstract: In an arrangement for producing a directional and cooled gas jet in an ion source with a gas inlet or a UV/fluorescence detection cell including a gas inlet, wherein a capillary extends with one end into the interior of the ion source which is evacuated, the one end is provided with a nozzle for discharging a gas sample into the ion source while being subjected to adiabatic cooling and the width of the nozzle opening is at most 40% of the inner diameter of the capillary and the capillary is heatable for preventing condensation of gas sample components in the nozzle.
    Type: Grant
    Filed: September 25, 2001
    Date of Patent: August 10, 2004
    Assignee: GSF-Forschaungszenfrum für Umwelt und Gesundheit GmbH
    Inventors: Ralf Zimmermann, Egmont Rohwer, Ralph Dorfner, Ulrich Boesl, Antonius Kettrup
  • Patent number: 6727499
    Abstract: In a method and apparatus for detecting compounds in a gas stream, the gas stream with the compounds to be detected is conducted into an ionization chamber of a mass spectrometer where the gas stream is subjected in the ion chamber in a pulsed manner alternately to UV laser pulses and to vacuum ultraviolet VUV laser pulses and the ions generated thereby are directed into the mass spectrometer for detection therein to determine the compounds in the gas stream.
    Type: Grant
    Filed: September 14, 2002
    Date of Patent: April 27, 2004
    Assignee: GSF-Forschungszentrum für Umwelt und Gesundheit GmbH
    Inventors: Ralf Zimmermann, Jorg Heger, Antonius Kettrup, Fabian Mühlberger, Klaus Hafner, Ulrich Boesl
  • Patent number: 6646253
    Abstract: In a gas inlet structure for an ion source, including a capillary for the admission of a sample gas, which capillary is disposed in a guide tube for discharging a sample gas into the guide tube, the guide tube has an open end disposed in the ion source. The guide tube includes a valve for the pulsed admission of a carrier gas to the guide tube. The guide tube, the valve and the capillary are supported in a sealed support housing from which the guide tube with the capillary disposed therein projects into the ion source for supplying thereto the sample gas in a pulsed manner.
    Type: Grant
    Filed: November 17, 2000
    Date of Patent: November 11, 2003
    Assignee: GSF-Forschungszentrum für Umwelt und Gesundheit GmbH
    Inventors: Egmont Rohwer, Ralf Zimmermann, Hans Jörg Heger, Ralf Dorfner, Ulrich Boesl, Antonius Kettrup
  • Publication number: 20030020014
    Abstract: In a method and apparatus for detecting compounds in a gas stream, the gas stream with the compounds to be detected is conducted into an ionization chamber of a mass spectrometer where the gas stream is subjected in the ion chamber in a pulsed manner alternately to UV laser pulses and to vacuum ultraviolet VUV laser pulses and the ions generated thereby are directed into the mass spectrometer for detection therein to determine the compounds in the gas stream.
    Type: Application
    Filed: September 14, 2002
    Publication date: January 30, 2003
    Inventors: Ralf Zimmermann, Jorg Heger, Antonius Kettrup, Fabian Muhlberger, Klaus Hafner, Ulrich Boesl
  • Patent number: 6390115
    Abstract: In a method for producing a directed gas jet wherein a guided sample gas beam is generated and an auxiliary gas beam is generated and directed and guided in the same direction as, but separated from, the sample gas beam, a pulsed carrier gas stream is generated and combined with the sample gas beam such that the sample gas beam is separated into spaced pulses which are embedded between the axially spaced pulses of the carrier gas beam and the carrier gas beam with the sample gas beam embedded therein is combined with the auxiliary gas beam such that the carrier and sample gas beam is radially enveloped by the auxiliary gas beam to from the directed gas jet of a carrier and sample gas pulses enveloped in the auxiliary gas beam.
    Type: Grant
    Filed: November 17, 2000
    Date of Patent: May 21, 2002
    Assignee: GSF-Forschungszentrum für Umwelt und Gesundheit
    Inventors: Egmont Rohwer, Ralf Zimmermann, Hans Jörg Heger, Ralph Dorfner, Ulrich Boesl, Antonius Kettrup
  • Publication number: 20020026821
    Abstract: In an arrangement for producing a directional and cooled gas jet in an ion source with a gas inlet or a UV/fluorescence detection cell including a gas inlet, wherein a capillary extends with one end into the interior of the ion source which is evacuated, the one end is provided with a nozzle for discharging a gas sample into the ion source while being subjected to adiabatic cooling and the width of the nozzle opening is at most 40% of the inner diameter of the capillary and the capillary is heatable for preventing condensation of gas sample components in the nozzle.
    Type: Application
    Filed: September 25, 2001
    Publication date: March 7, 2002
    Inventors: Ralf Zimmermann, Egmont Rohwer, Ralph Dorfner, Ulrich Boesl, Antonius Kettrup
  • Publication number: 20020007687
    Abstract: In a method for detecting trace substances or environmental properties, wherein a collection structure including a collection-active material is layed out following a predetermined pattern, and, after a certain exposure time, the collection structure is reeled in and the collection structure is analyzed in a location-dependent manner, the analysis values are correlated with the layout pattern of the collection structure to establish an analysis value pattern over the area in which the collection structure was layed out.
    Type: Application
    Filed: September 4, 2001
    Publication date: January 24, 2002
    Inventors: Ralf Zimmermann, Antonius Kettrup