Patents by Inventor Ralph A. Rivero

Ralph A. Rivero has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel substituted diamine derivatives useful as motlin antagonists
    Publication number: 20030203906
    Abstract: The present invention relates to novel substituted diamine derivatives for the formula 1
    Type: Application
    Filed: November 8, 2002
    Publication date: October 30, 2003
    Inventors: Sigmong G. Johnson, Ralph A. Rivero
  • Substituted aminoalkylamide derivatives as antagonists of follicle stimulating hormone
    Patent number: 6583179
    Abstract: The present invention is directed to a series of novel substituted aminoalkylamide derivatives, pharmaceutical compositions containing them and their use in the treatment of reproductive disorders and affective conditions. Further, the compounds of the invention are antagonists of follicle stimulating hormone, a hormone associated with the human reproductive system.
    Type: Grant
    Filed: December 21, 2000
    Date of Patent: June 24, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Steven J. Coats, Louis J. Fitzpatrick, Dennis J. Hlasta, Carolina L. Lanter, Mark J. Macielag, Ke Pan, Ralph A. Rivero, Stephen S. Palmer
  • Substituted diamine derivatives useful as motilin antagonists
    Patent number: 6511980
    Abstract: The present invention relates to novel substituted diamine derivatives for the formula wherein R1, R2, R3, R4, X1, X2, X3, X4, A, Y and n are as described in the specification, pharmaceutical compositions containing them and intermediates used in their manufacture. More particularly, the compounds of the invention are motilin receptor antagonists useful for the treatment of associated conditions and disorders such as gastrointestinal reflux disorders, eating disorders leading to obesity and irritable bowel syndrome.
    Type: Grant
    Filed: April 10, 2001
    Date of Patent: January 28, 2003
    Assignee: Ortho McNeil Pharmaceutical, Inc.
    Inventors: Sigmond G. Johnson, Ralph A. Rivero
  • Substituted aminoalkylamide derivatives as antagonists of follicle stimulating hormone
    Publication number: 20020058654
    Abstract: The present invention is directed to a series of novel substituted aminoalkylamide derivatives, pharmaceutical compositions containing them and their use in the treatment of reproductive disorders and affective conditions. Further, the compounds of the invention are antagonists of follicle stimulating hormone, a hormone associated with the human reproductive system.
    Type: Application
    Filed: December 21, 2000
    Publication date: May 16, 2002
    Inventors: Steven J. Coats, Louis J. Fitzpatrick, Dennis J. Hlasta, Carolina L. Lanter, Mark J. Macielag, Ke Pan, Ralph A. Rivero, Stephen S. Palmer
  • Novel substituted diamine derivatives useful as motilin antagonists
    Publication number: 20020013352
    Abstract: The present invention relates to novel substituted diamine derivatives for the formula 1
    Type: Application
    Filed: April 10, 2001
    Publication date: January 31, 2002
    Inventors: Sigmond G. Johnson, Ralph A. Rivero
  • Solid-phase synthesis of novel 14-membered macroycles for high throughput screening
    Patent number: 6228986
    Abstract: The preparation of 14-membered macrocycles from a resin-bound orthogonally protected lysine residue is described. Reductive alkylation of the a-nitrogen followed by acylation with an Fmoc-aminoacid provides a protected dipeptide precursor. Removal of the Fmoc-group, acylation with a succinic anhydride, methyltrityl-group removal and macrocyclization provides the desired macrocycles, after TFA cleavage, in excellent yield and purity.
    Type: Grant
    Filed: April 7, 1999
    Date of Patent: May 8, 2001
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Carolina L. Lanter, Joseph W. Guiles, Ralph A. Rivero
  • Phenoxyphenylacetic acid derivatives
    Patent number: 5767310
    Abstract: Phenoxyphenylacetic acids and derivatives of general structural formula (I) have endothelin antagonist activity and are useful in treating cardiovascular disorders, such as hypertension, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, endoxic shock, benign prostatic hyperplasia, inflammatory diseases including Raynaud's disease and asthma.
    Type: Grant
    Filed: November 8, 1995
    Date of Patent: June 16, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Scott W. Bagley, Theodore P. Broten, Prasun K. Chakravarty, Daljit S. Dhanoa, Kenneth J. Fitch, William J. Greenlee, Nancy Jo Kevin, Douglas J. Pettibone, Ralph A. Rivero, James R. Tata, Thomas F. Walsh, David L. Williams, Jr.
  • Phenoxyphenylacetic acid derivatives
    Patent number: 5668176
    Abstract: Phenoxyphenylacetic acids and derivatives of the general structural formula I ##STR1## have endothelin antagonist activity and are useful in treating cardiovascular disorders, such as hypertension, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, endotoxic shock, benign prostatic hyperplasia, inflammatory diseases including Raynaud's disease and asthma.
    Type: Grant
    Filed: October 18, 1996
    Date of Patent: September 16, 1997
    Assignee: Merck & Co. Inc.
    Inventors: Scott W. Bagley, Theodore P. Broten, Prasun K. Chakravarty, Daljit S. Dhanoa, Kenneth J. Fitch, William J. Greenlee, Nancy Jo Kevin, Gerard R. Kieczykowski, Douglas J. Pettibone, James R. Tata, Ralph A. Rivero, Thomas F. Walsh, David L. Williams, Jr., Jay M. Matthews, Richard B. Toupence
  • Biphenyl compounds useful or endothelin antagonists
    Patent number: 5565485
    Abstract: Phenoxyphenylacetic acids and derivatives of the general structural formula I ##STR1## have endothelin antagonist activity and are useful in treating cardiovascular disorders, such as hypertension, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, endotoxic shock, benign prostatic hyperplasia, inflammatory diseases including Raynaud's disease and asthma.
    Type: Grant
    Filed: August 22, 1994
    Date of Patent: October 15, 1996
    Assignee: Merck & Co., Inc.
    Inventors: Scott W. Bagley, Theodore P. Broten, Prasun K. Chakravarty, Daljit S. Dhanoa, Kenneth J. Fitch, William J. Greenlee, Nancy J. Kevin, Douglas J. Pettibone, Ralph A. Rivero, Thomas F. Walsh, David L. Williams, Jr., Richard B. Toupence, Jay M. Matthews
  • Substituted biphenylmethylimidazopyridines
    Patent number: 5554625
    Abstract: Biphenylmethylimidazopyridines of the structure (I) are angiotensin (II) antagonists and therefore useful in the treatment of hypertension and related cardiovascular disorders and ocular hypertension.
    Type: Grant
    Filed: January 6, 1995
    Date of Patent: September 10, 1996
    Assignee: Merck & Co., Inc.
    Inventors: Ralph A. Rivero, Prasun K. Chakravarty, William J. Greenlee, Nancy J. Kevin, Nathan B. Mantlo
  • Endothelin antagonists incorporating a cyclobutane
    Patent number: 5492917
    Abstract: Novel compounds of the general structural formula I: ##STR1## have endothelin antagonist activity and are therefore useful in treating cardiovascular disorders, such as hypertension, pulmonary hypertension, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, endotoxic shock, inflammatory diseases including Raynaud's disease and asthma.
    Type: Grant
    Filed: September 29, 1993
    Date of Patent: February 20, 1996
    Assignee: Merck & Co., Inc.
    Inventors: Ralph A. Rivero, Peter D. Williams, Daniel F. Veber
  • Angiotensin II antagonists incorporating a substituted benzyl element
    Patent number: 5449682
    Abstract: Substituted heterocycles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I are useful as angiotensin II antagonists. ##STR1## wherein the substituents are as defined in the claims.
    Type: Grant
    Filed: May 17, 1993
    Date of Patent: September 12, 1995
    Assignee: Merck & Co., Inc.
    Inventors: William J. Greenlee, David Hangauer, Arthur A. Patchett, Thomas F. Walsh, Kenneth J. Fitch, Daljit S. Dhanoa, Ralph A. Rivero
  • Pharmaceutical treatment methods using angiotensin II receptor agonists bearing a thiophene moiety
    Patent number: 5444067
    Abstract: This invention relates to compounds represented by formula I: ##STR1## which are agonists of angiotensin II. The invention is also concerned with the use of aforementioned agonists in the treatment of states meditated by angiotensin.
    Type: Grant
    Filed: August 30, 1993
    Date of Patent: August 22, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Salah Kivlighn, Victor J. Lotti, Ralph A. Rivero, Peter K. S. Siegl, Gloria J. Zingaro
  • Heterocyclic compounds bearing acidic functional groups as angiotensin II antagonists
    Patent number: 5412097
    Abstract: Heterocyclic compounds of structural formula: ##STR1## wherein A, B, C, and D are independently carbon atoms or nitrogen atoms are angiotensin II antagonists useful in the treatment of hypertension and congestive heart failure.
    Type: Grant
    Filed: September 2, 1992
    Date of Patent: May 2, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Prasun K. Chakravarty, William J. Greenlee, Dooseop Kim, Nathan B. Mantlo, Arthur A. Patchett, Ralph A. Rivero
  • Substituted carbamoyl and oxycarbonyl derivatives of biphenylmethylamines
    Patent number: 5312820
    Abstract: Carbamoyl and oxycarbonyl derivatives of biphenylmethylamines of structure I are angiotensin-II antagonists with balanced AT.sub.1 and AT.sub.2 activity useful in the treatment of hypertension and related disorders and ocular hypertension. ##STR1## where X is --O-- or --N(R.sup.7)--.
    Type: Grant
    Filed: July 17, 1992
    Date of Patent: May 17, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Wallace T. Ashton, Linda L. Chang, William J. Greenlee, Steven M. Hutchins, Ralph A. Rivero
  • Quinazolinone, triazolinone and pyrimidinone angiotensin II antagonists incorporating a substituted benzyl element
    Patent number: 5264439
    Abstract: Substituted heterocycles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I are useful as angiotensin II antagonists.
    Type: Grant
    Filed: August 13, 1991
    Date of Patent: November 23, 1993
    Assignee: Merck & Co., Inc.
    Inventors: William J. Greenlee, David Hangauer, Arthur A. Patchett, Thomas F. Walsh, Kenneth J. Fitch, Daljit S. Dhanoa, Ralph A. Rivero
  • Angiotensin II antagonists incorporating a substituted thiophene or furan
    Patent number: 5252574
    Abstract: Substituted heterocycles attached through a methylene bridge to novel substituted phenyl thiophene or phenyl furan derivative of the Formula I are useful as angiotensin II antagonists.
    Type: Grant
    Filed: March 11, 1992
    Date of Patent: October 12, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Eric E. Allen, Nancy Kevin, Tomasz W. Glinka, Ralph A. Rivero
  • Angiotensin II antagonists incorporating a substituted pyridoimidazolyl ring
    Patent number: 5240938
    Abstract: Substituted heterocycles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I are useful as angiotensin II antagonists.
    Type: Grant
    Filed: August 13, 1991
    Date of Patent: August 31, 1993
    Assignee: Merck & Co., Inc.
    Inventors: William J. Greenlee, Arthur A. Patchett, David Hangauer, Thomas F. Walsh, Kenneth J. Fitch, Ralph A. Rivero, Daljit S. Dhanoa
  • 6-amino substituted imidazo[4,5-bipyridines as angiotensin II antagonists
    Patent number: 5223499
    Abstract: Substituted imidazo[4,5-b]pyridines of structural formula: ##STR1## are angiotensin II antagonists useful in the treatment of hypertension and congestive heart failure.
    Type: Grant
    Filed: May 11, 1992
    Date of Patent: June 29, 1993
    Assignee: Merck & Co., Inc.
    Inventors: William J. Greenlee, Dooseop Kim, Nathan B. Mantlo, Arthur A. Pastchett, Ralph A. Rivero
  • Angiotensin II antagonists incorporating a substituted thiophene or furan
    Patent number: 5198438
    Abstract: Substituted imidazoles attached through a methylene bridge to novel substituted phenyl thiophene or phenyl furan derivative of the Formula I are useful as angiotensin II antagonists.
    Type: Grant
    Filed: March 11, 1992
    Date of Patent: March 30, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Eric E. Allen, Ralph A. Rivero, Nancy Kevin