Patents by Inventor Ralph B. Arlinghaus

Ralph B. Arlinghaus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for the preparation and use of site-directed immunologic reagents
    Patent number: 5126399
    Abstract: Disclosed are peptidyl-resin conjugates made up of an immunogenic/antigenic peptide conjugated to a polyamide resin, wherein the peptide incorporates a helper T-cell epitope. The inclusion of a T-cell epitope in this peptide sequence provides particular benefits in the preparation of site-directed reagents intended as immunogens. In exemplary studies, a synthetic peptide predicted from Abelson murine leukemia virus abl oncogene (residues 389-403) was synthesized with a T-cell active epitope of 7 amino acids placed at its N-terminus (T-abl-resin). The T-abl-resin construct was found to greatly stimulate the immune response giving significantly higher specific antibody titers than abl-resin controls.
    Type: Grant
    Filed: June 20, 1989
    Date of Patent: June 30, 1992
    Assignees: Board of Regents, The University of Texas System, Baylor College of Medicine
    Inventors: Ralph B. Arlinghaus, James T. Sparrow