Patents by Inventor Ralph B. Nielsen
Ralph B. Nielsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7115234Abstract: A method and apparatus for reacting a plurality of different mixtures in parallel in a semi-batch or continuous mode is provided. Each reaction is contained within a reactor vessel, the reactor vessels combined into a reactor block. Reactant(s) to be added during the reaction are kept in a header barrel, which has a plunger to feed reactant(s) from the header barrel through a transfer line into the reactor vessel. The plunger is moved using a drive system. The header barrels are optionally combined in a header block. The header block is sealed to a plate containing the transfer lines, which in turn is sealed to the reactor block. A latch mechanism is provided for easy sealing of the reactor and header blocks to the plate. The entire apparatus may be placed on a rocker or rotating plate for mixture as the reaction is proceeding.Type: GrantFiled: December 9, 2002Date of Patent: October 3, 2006Assignee: Symyx Technologies, Inc.Inventors: J. Christopher Freitag, Damian Hajduk, Ralph B. Nielsen, Adam Safir, Richard Tiede
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Patent number: 7067586Abstract: Block copolymers are prepared by living-type or semi-living type free radical polymerization, with said copolymers having at least one random block comprised of at least one hydrophobic monomer and at least one hydrophilic monomer. The selection of hydrophobic and hydrophilic monomers in the random block is determined by the relative hydrophobicity of the monomers to impart selected solubility or dispersability in water and/or alcohols of the overall block copolymer.Type: GrantFiled: June 29, 2004Date of Patent: June 27, 2006Assignee: Symyx Technologies, Inc.Inventors: Mingjun Liu, Damian Hajduk, Jean M. J. Frechet, Ezat Khoshdel, Ralph B. Nielsen, Dominique Charmot
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Patent number: 6976383Abstract: Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.Type: GrantFiled: March 31, 2003Date of Patent: December 20, 2005Assignee: Symyx Technologies, Inc.Inventors: Miroslav Petro, Adam Safir, Ralph B. Nielsen, G. Cameron Dales, Eric D. Carlson, Thomas S. Lee
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Patent number: 6924149Abstract: Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure.Type: GrantFiled: August 28, 2002Date of Patent: August 2, 2005Assignee: Symyx Technologies, Inc.Inventors: Howard Turner, G. Cameron Dales, Lynn VanErden, Johannes A. M. Van Beek, Damian A. Hajduk, Ralph B. Nielsen, William C. Rust
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Patent number: 6890492Abstract: Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.Type: GrantFiled: November 28, 2000Date of Patent: May 10, 2005Assignee: Symyx Technologies, Inc.Inventors: Howard Turner, G. Cameron Dales, Lynn VanErden, Johannes A. M. Van Beek, Damian A. Hajduk, Ralph B. Nielsen, Paul Mansky, Leonid Matsiev, Pei Wang, Eric McFarland
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Patent number: 6890522Abstract: Cosmetic or personal care compositions, such as for styling hair, comprise a thermoplastic elastomer which is a block copolymer comprising a core polymer having a backbone comprising at least a proportion of C—C bonds and two or more flanking polymers. Each flanking polymer is covalently bound to an end of the core polymer and the core polymer and/or at least one of the flanking polymers is a copolymer derived from two or more monomers. The compositions comprise a cosmetically acceptable diluent or carrier.Type: GrantFiled: October 30, 2003Date of Patent: May 10, 2005Assignee: Unilever Home & Personal Care USA, division of Conopco, Inc.Inventors: Jean M. J. Frechet, Damian Hajduk, Ezat Khoshdel, Mingjun Liu, Ralph B. Nielsen, Euan Stuart Reid, Keith Leslie Rutherford
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Patent number: 6864092Abstract: Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.Type: GrantFiled: November 28, 2000Date of Patent: March 8, 2005Assignee: Symyx Technologies, Inc.Inventors: Howard Turner, G. Cameron Dales, Lynn VanErden, Johannes A. M. VanBeek, Damian A. Hajduk, Ralph B. Nielsen, Paul Mansky, Leonid Matsiev, Pei Wang, Eric McFarland
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Patent number: 6834990Abstract: Method and apparatus for mixing small volumes of reaction components. In one application, a plurality of removable vessels are placed in a parallel reactor, and reaction components are delivered to each vessel. An impeller is rotated in each vessel to mix the components. Each impeller has a rotary shaft and at least one blade on the shaft for placement in the reaction components. The blade is dimensioned so that one rotation of the impeller causes the blade to sweep out a sweep volume representing a large amount of the fill volume of the vessel.Type: GrantFiled: April 8, 2003Date of Patent: December 28, 2004Assignee: Symyx Technologies, Inc.Inventor: Ralph B. Nielsen
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Patent number: 6833276Abstract: Sensors for determining the presence and concentration of bio-molecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface that is modified with a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled free radical polymerization techniques, and in particular the use of an iniferter initiator, which allows for controlled architecture polymers to modify the surface of the substrate. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.Type: GrantFiled: July 24, 2001Date of Patent: December 21, 2004Assignee: Symyx Technologies, Inc.Inventors: Gerrit Klaerner, Ralph B. Nielsen, Paul Mansky, Didier Benoit, Dominique Charmot, Bernd Jandeleit, Laura T. Mazzola
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Publication number: 20040242789Abstract: Block copolymers are prepared by living-type or semi-living type free radical polymerization, with said copolymers having at least one random block comprised of at least one hydrophobic monomer and at least one hydrophilic monomer. The selection of hydrophobic and hydrophilic monomers in the random block is determined by the relative hydrophobicity of the monomers to impart selected solubility or dispersability in water and/or alcohols of the overall block copolymer.Type: ApplicationFiled: June 29, 2004Publication date: December 2, 2004Applicant: Symyx Technologies, Inc.Inventors: Mingjun Liu, Damian Hajduk, Jean M.J. Frechet, Ezat Khoshdel, Ralph B. Nielsen, Dominique Charmot
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Patent number: 6818183Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.Type: GrantFiled: April 29, 2002Date of Patent: November 16, 2004Assignee: Symyx Technologies, Inc.Inventors: Damian A. Hajduk, Ralph B. Nielsen, Adam Safir, Leonid Matsiev, Eric McFarland, Paul Mansky
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Patent number: 6787112Abstract: Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.Type: GrantFiled: November 28, 2000Date of Patent: September 7, 2004Assignee: Symyx Technologies, Inc.Inventors: Howard Turner, G. Cameron Dales, Lynn VanErden, Johannes A. M. VanBeek, Damian A. Hajduk, Ralph B. Nielsen, William C. Rust
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Patent number: 6767968Abstract: Block copolymers are prepared by living-type or semi-living type free radical polymerization, with said copolymers having at least one random block comprised of at least one hydrophobic monomer and at least one hydrophilic monomer. The selection of hydrophobic and hydrophilic monomers in the random block is determined by the relative hydrophobicity of the monomers to impart selected solubility or dispersability in water and/or alcohols of the overall block copolymer.Type: GrantFiled: October 3, 2000Date of Patent: July 27, 2004Assignee: Symyx Technologies, Inc.Inventors: Mingjun Liu, Damian Hajduk, Jean M. J. Fréchet, Ezat Khoshdel, Ralph B. Nielsen, Dominique Charmot
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Publication number: 20040096411Abstract: Cosmetic or personal care compositions, such as for styling hair, comprise a thermoplastic elastomer which is a block copolymer comprising a core polymer having a backbone comprising at least a proportion of C—C bonds and two or more flanking polymers. Each flanking polymer is covalently bound to an end of the core polymer and the core polymer and/or at least one of the flanking polymers is a copolymer derived from two or more monomers. The compositions comprise a cosmetically acceptable diluent or carrier.Type: ApplicationFiled: October 30, 2003Publication date: May 20, 2004Applicant: Unilever Home & Personal Care USA, Division of Conopco, Inc.Inventors: Jean M.J. Frechet, Damian Hajduk, Ezat Khoshdel, Mingjun Liu, Ralph B. Nielsen, Euan Stuart Reid, Keith Leslie Rutherford
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Patent number: 6726843Abstract: Methods and apparatus for the evaluation of interactions between substances using inverse chromatography are disclosed. Preferably, interactions are evaluated between a liquid test sample and a solid phase comprising a receptor in the presence of a liquid carrier. Preferably, one of the modifying agent or receptor are members of a combinatorial library.Type: GrantFiled: June 24, 2002Date of Patent: April 27, 2004Assignee: Symyx Technologies Inc.Inventors: Miroslav Petro, Ralph B. Nielsen, Jacqueline M. Regan
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Patent number: 6720186Abstract: A method and system for researching and developing and/or optimizing new catalysts and products in a combinatorial manner is disclosed. The method begins with starting components or a ligand library and provides methods of creating catalyst or product libraries, which are then tested in a reaction of interest. The system uses methods of robotic handling for moving libraries from station to station. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial catalyst libraries, but also offer significant advantages over conventional experimental methods as well.Type: GrantFiled: January 8, 1999Date of Patent: April 13, 2004Assignee: Symyx Technologies, Inc.Inventors: Howard W. Turner, Adam Safir, Ralph B. Nielsen
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Patent number: 6692914Abstract: Sensors for determining the presence and concentration of bio-molecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface that is modified with a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled free radical polymerization techniques, which allows for controlled architecture polymers to modify the surface of the substrate. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.Type: GrantFiled: July 3, 2000Date of Patent: February 17, 2004Assignee: Symyx Technologies, Inc.Inventors: Gerrit Klaerner, Ralph B. Nielsen, Paul Mansky, Didier Benoit, Dominique Charmot, Bernd Jandeleit, Laura T. Mazzola
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Publication number: 20040025575Abstract: Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.Type: ApplicationFiled: March 31, 2003Publication date: February 12, 2004Inventors: Miroslav Petro, Adam Safir, Ralph B. Nielsen, G. Cameron Dales, Eric D. Carlson, Thomas S. Lee
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Patent number: 6685925Abstract: Cosmetic or personal care compositions, such as for styling hair, comprise a thermoplastic elastomer which is a block copolymer comprising a core polymer having a backbone comprising at least a proportion of C—C bonds and two or more flanking polymers. Each flanking polymer is covalently bound to an end of the core polymer and the copolymer is soluble at a level of at least 1% by weight in water at 25° C. The compositions comprise a cosmetically acceptable diluent or carrier.Type: GrantFiled: October 3, 2001Date of Patent: February 3, 2004Inventors: Jean M. J. Frechet, Damian Hajduk, Ezat Khoshdel, Mingjun Liu, Ralph B. Nielsen, Euan Stuart Reid, Keith Leslie Rutherford
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Patent number: 6663855Abstract: Cosmetic or personal care compositions, such as for styling hair, comprise a thermoplastic elastomer which is a block copolymer comprising a core polymer having a backbone comprising at least a proportion of C—C bonds and two or more flanking polymers. Each flanking polymer is covalently bound to an end of the core polymer and the core polymer and/or at least one of the flanking polymers is a copolymer derived from two or more monomers. The compositions comprise a cosmetically acceptable diluent or carrier.Type: GrantFiled: October 3, 2001Date of Patent: December 16, 2003Assignee: Unilever Home & Personal Care USA, division of Conopco, Inc.Inventors: Jean M. J. Frechet, Damian Hajduk, Ezat Khoshdel, Mingjun Liu, Ralph B. Nielsen, Euan Stuart Reid, Keith Leslie Rutherford