Abstract: A strip casting system for aluminium and/or aluminium alloys comprising a casting furnace and a revolving chill mould having a casting gap. The revolving chill mould is designed as a roll pair, roller pair, caterpillar pair or belt pair. The strip casting system has an active means for transporting metal melt from the casting furnace to the casting gap and a casting region arranged in front of the casting gap. The casting region is delimited on one side by the revolving chill mould. A melt pool is formed in the casting region, from which metal melt flows or is drawn into the casting gap. The casting furnace is connected to the casting region by a pipe system with means for feeding the metal melt into the casting region, which can feed the metal melt to the casting region below the surface of the melt pool formed in the casting region.

Abstract: The present invention relates to a base editing compound comprising or consisting of (a) a Cas protein, and, covalently connected therewith; (b) a nucleobase-modifying enzyme, wherein the covalent connection of (a) and (b) is (i) direct; (ii) provided by a peptide comprising at least one Pro residue, said peptide having a length between 1 and 20 preferably between 1 and 15 amino acids; or (iii) provided by a non-peptidic linker, said non-peptidic linker being a small organic molecule comprising one or more double bonds, one or more triple bonds, and/or one or more aromatic rings.

Abstract: A strip casting system for aluminium and/or aluminium alloys comprising a casting furnace and a revolving chill mould having a casting gap. The revolving chill mould is designed as a roll pair, roller pair, caterpillar pair or belt pair. The strip casting system has an active means for transporting metal melt from the casting furnace to the casting gap and a casting region arranged in front of the casting gap. The casting region is delimited on one side by the revolving chill mould. A melt pool is formed in the casting region, from which metal melt flows or is drawn into the casting gap. The casting furnace is connected to the casting region by a pipe system with means for feeding the metal melt into the casting region, which can feed the metal melt to the casting region below the surface of the melt pool formed in the casting region.

Abstract: The present invention lies in the field of plant protection, in particular in the field of controlling plant pests and pathogens that affect plants. The present invention relates to a plant comprising a plastid comprising a double-stranded RNA (dsRNA) capable of silencing at least one target gene of a pest of a plant or of an agent causing a disease of a plant. The present invention further relates to such a transplastomic plant, wherein said dsRNA comprises two (separate) complementary single-stranded RNA strands. The present invention further relates to a plastid as comprised in the plant of the invention and to a plant cell comprising said plastid. Moreover, the present invention relates to a method of producing a plant of the invention and to a method of controlling a pest of a plant or a plant disease-causing agent or of protecting a plant from said pest or agent.

Abstract: The present invention relates to a method of generating eukaryotic cells suitable for the expression of transgenes in said cells comprising (a) introducing a nucleic acid encoding a selectable marker responsive to a selecting agent into the nucleus of cells, wherein the level of expression of said selectable marker is proportional to the level of phenotypic responsiveness to said selecting agent; (b) selecting, among the cells obtained in step (a), for cells with a detectable expression of said selectable marker; (c) optionally propagating the cells selected for in step (b); (d) mutagenizing the cells selected for in step (b) or propagated in step (c) or allowing for the appearance of spontaneous mutations in the cells selected for in step (b) or propagated in step (c); and (e) selecting for cells displaying an increased expression of said selectable marker compared to the expression obtained in step (b).

Abstract: The invention is a bus bar comprising a cover part made of an insulating material, and a bottom part comprising two chambers each for the reception of one pole connector. A chamber partition wall is arranged between each set of chambers, wherein at least one connecting lug is arranged on a corresponding pole connector. The cover part can be set on the bottom part in such a way that each of the pole connectors is covered, and each of the connecting lugs extends out through corresponding openings in the cover part. At least one partition wall is arranged on the cover part, which is positioned between two adjacent connecting lugs when the cover part is set on the bottom part. The bottom part is closable on its front side by a set of one or more end caps.

Abstract: The invention is a bus bar comprising a cover part made of an insulating material, and a bottom part comprising two chambers each for the reception of one pole connector. A chamber partition wall is arranged between each set of chambers, wherein at least one connecting lug is arranged on a corresponding pole connector. The cover part can be set on the bottom part in such a way that each of the pole connectors is covered, and each of the connecting lugs extends out through corresponding openings in the cover part. At least one partition wall is arranged on the cover part, which is positioned between two adjacent connecting lugs when the cover part is set on the bottom part. The bottom part is closable on its front side by a set of one or more end caps.

Abstract: The present invention provides methods for obtaining stably transformed transplastomic plant cell material belonging to the genus Lycopersicon (tomato) and having the potential to regenerate into mature fertile plants. The method generally comprises (a) transforming plastids of said plant cell material with a DNA molecule carrying an expression cassette encoding at least one protein of interest, and a target sequence enabling homologous recombination; (b) selecting plant cell material until substantially all plastids have been transformed with said DNA molecule, thereby obtaining said stably transformed transplastomic plant cell material; and, optionally (c) regenerating said transplastomic plant cell material into mature fertile plants.