Patents by Inventor Ralph Dornburg

Ralph Dornburg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cell type specific gene transfer using retroviral vectors containing antibody-envelope fusion proteins and wild-type envelope fusion proteins
    Patent number: 6534051
    Abstract: A method of infecting target cells with retroviral vector particles having target cell specificity. The retroviral vector particles have a chimeric envelope protein consisting of an antigen binding site of an antibody or another peptide, fused to the envelope protein the retroviral vector. The antigen binding site or other peptide disrupts the natural viral receptor binding site. The method includes producing the retroviral vector and contacting the vector with the target cell such that the vector is internalized by the cell.
    Type: Grant
    Filed: August 17, 1998
    Date of Patent: March 18, 2003
    Assignee: University of Medicine and Dentistry of New Jersey
    Inventor: Ralph Dornburg
  • Genetically engineered retroviral vector particles capable of infecting non-dividing cells
    Patent number: 6303116
    Abstract: The present invention is a method of generating retroviral vector particles derived from retroviruses and capable of transducing therapeutic genes into non-dividing cells.
    Type: Grant
    Filed: February 2, 2000
    Date of Patent: October 16, 2001
    Assignee: Thomas Jefferson University
    Inventor: Ralph Dornburg
  • Mammalian homologous recombination activating sequences and method of identification and their use thereof
    Patent number: 6200750
    Abstract: Methods of identifying homologous recombination activators are provided. These recombination activators can be use for gene therapy.
    Type: Grant
    Filed: September 23, 1997
    Date of Patent: March 13, 2001
    Assignees: Thomas Jefferson University, University of Medicine and Dentistry
    Inventors: Ralph Dornburg, Paul K. Olson