Abstract: There is disclosed herein improved pallet locating and clamping mechanisms for use in conjunction with the work transfer device in a transfer machine. The pallet locating and clamping means comprise a plurality of inverted V-blocks accurately positioned in the work stations of the machine which are adapted to cooperate with complementary V-grooves provided in the undersides of the pallets for automatically positioning and supporting such pallets precisely in the work stations perparatory to machining or other work operations to be performed on workpieces carried by the pallets. The clamping means for the pallets preferably are mechanically actuated and correlated with the pallet transfer device to clamp the pallets securely on the locating and supporting V-blocks.