Patents by Inventor Ralph Gillen

Ralph Gillen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10390743
    Abstract: Electrode systems are disclosed for measuring the concentration of an analyte under in-vivo conditions, where such systems include a counter electrode having an electrical conductor, a working electrode having an electrical conductor on which an enzyme layer containing immobilized enzyme molecules for catalytic conversion of the analyte is arranged, and a diffusion barrier that slows the diffusion of the analyte from body fluid surrounding the electrode system to enzyme molecules. The enzyme layer is in the form of multiple fields that are arranged on the conductor of the working electrode at a distance from each other.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: August 27, 2019
    Assignee: ROCHE DIABETES CARE, INC.
    Inventors: Ewald Rieger, Reinhold Mischler, Ortrud Quarder, Arnulf Staib, Ulrike Kamecke, Ralph Gillen
  • Patent number: 9394563
    Abstract: An electrode system for measuring the concentration of an analyte under in-vivo conditions comprises a counter-electrode having an electrical conductor, a working electrode having an electrical conductor on which an enzyme layer containing immobilized enzyme molecules for catalytic conversion of the analyte is arranged, and a diffusion barrier that slows the diffusion of the analyte from body fluid surrounding the electrode system to enzyme molecules. The enzyme layer is in the form of multiple fields that are arranged on the conductor of the working electrode at a distance from each other.
    Type: Grant
    Filed: March 8, 2011
    Date of Patent: July 19, 2016
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Ortrud Quarder, Arnulf Staib, Reinhold Mischler, Ewald Rieger, Ralph Gillen, Ulrike Kamecke
  • Publication number: 20110196216
    Abstract: An electrode system for measuring the concentration of an analyte under in-vivo conditions comprises a counter-electrode having an electrical conductor, a working electrode having an electrical conductor on which an enzyme layer containing immobilized enzyme molecules for catalytic conversion of the analyte is arranged, and a diffusion barrier that slows the diffusion of the analyte from body fluid surrounding the electrode system to enzyme molecules. The enzyme layer is in the form of multiple fields that are arranged on the conductor of the working electrode at a distance from each other.
    Type: Application
    Filed: March 8, 2011
    Publication date: August 11, 2011
    Inventors: Ortrud Quarder, Arnulf Staib, Reinhold Mischler, Ewald Rieger, Ralph Gillen, Ulrike Kamecke
  • Patent number: 7389133
    Abstract: The disclosure generally relates to continuous monitoring of an analyte by determining its change over time in the living body of a human or animal. A measurement variable value correlating with the desired concentration of the analyte are measured as the measurement signal (zt) and the change over time of the concentration is determined from the measurement signal as the useful signal (yt) using a calibration. A filter algorithm is used to reduce errors of the useful signal, which result from noise contained in the measurement signal. The filter algorithm includes an operation in which the influence of an actual measurement value on the useful signal is weighted using a weighting factor (V).
    Type: Grant
    Filed: October 11, 2007
    Date of Patent: June 17, 2008
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Reinhard Kotulla, Arnulf Staib, Ralph Gillen
  • Publication number: 20080139902
    Abstract: The disclosure generally relates to continuous monitoring of an analyte by determining its change over time in the living body of a human or animal. A measurement, variable value correlating with the desired concentration of the analyte are measured as the measurement signal (zt) and the change over time of the concentration is determined from the measurement signal as the useful signal (yt) using a calibration. A filter algorithm is used to reduce errors of thee useful signal, which result from noise contained in the measurement signal. The filter algorithm includes an operation in which the influence of an actual measurement value on the useful signal is weighted using a weighting factor (V).
    Type: Application
    Filed: October 11, 2007
    Publication date: June 12, 2008
    Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.
    Inventors: Reinhard Kotulla, Arnulf Staib, Ralph Gillen
  • Publication number: 20070151868
    Abstract: An electrode system for determining an analyte concentration in a human or animal may comprise first and second electrodes. The first electrode may be configured to produce a first signal from which the analyte concentration can be determined, and may have a first measuring sensitivity that is optimized for a first analyte concentration range. The second electrode may be configured to produce a second signal from which the analyte concentration can be determined, and may have a second measuring sensitivity that is optimized for a second analyte concentration range that is different from the first analyte concentration range. An analytical unit may be configured to determine the analyte concentration based on the first signal if the analyte concentration falls within the first analyte concentration range, and to determine the analyte concentration based on the second signal if the analyte concentration falls within the second analyte concentration range.
    Type: Application
    Filed: November 12, 2006
    Publication date: July 5, 2007
    Inventors: Arnulf Staib, Ralph Gillen
  • Publication number: 20060052679
    Abstract: The present invention generally relates to a method for continuous monitoring of the concentration of an analyte by determining its change over time in the living body of a human or animal. A measurement variable value correlating with the desired concentration of the analyte are measured as the measurement signal (zt) and the change over time of the concentration is determined from the measurement signal as the useful signal (yt) using a calibration. A filter algorithm is used to reduce errors of the useful signal, which result from noise contained in the measurement signal. The filter algorithm includes an operation in which the influence of an actual measurement value on the useful signal is weighted using a weighting factor (V).
    Type: Application
    Filed: November 3, 2005
    Publication date: March 9, 2006
    Inventors: Reinhard Kotulla, Arnulf Staib, Ralph Gillen