Patents by Inventor Ralph Heasley

Ralph Heasley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GASTRIC RETENTIVE EXTENDED RELEASE PHARMACEUTICAL COMPOSITIONS
    Publication number: 20140294956
    Abstract: The present disclosure provides extended release pharmaceutical compositions comprising an opioid and an additional active pharmaceutical ingredient, wherein the composition exhibits gastric retentive properties which are achieved by a combination of a physical property of the composition and release of the opioid, wherein upon administration to a subject, the composition has at least one pharmacokinetic parameter that differs by less than about 30% when the subject is in a fasted state as compared to a fed state.
    Type: Application
    Filed: June 11, 2014
    Publication date: October 2, 2014
    Inventors: Krishna R. Devarakonda, Michael J. Giuliani, Vishal K. Gupta, Ralph A. Heasley, Susan Shelby
  • Extended Release Compositions Comprising Hydrocodone And Acetaminophen For Rapid Onset And Prolonged Analgesia That May Be Administered Without Regard To Food
    Publication number: 20140288113
    Abstract: The present disclosure provides an extended release pharmaceutical composition comprising hydrocodone and acetaminophen that provides a rapid onset of analgesia, and reduced levels of acetaminophen near the end of the dosing interval. Also provided are methods for reducing the risk of acetaminophen-induced hepatic damage in a subject being treated with an acetaminophen containing composition, as well as methods for treating pain in a subject in need thereof.
    Type: Application
    Filed: February 24, 2014
    Publication date: September 25, 2014
    Applicant: MALLINCKRODT LLC
    Inventors: Krishna R. Devarakonda, Michael J. Giuliani, Vishal K. Gupta, Ralph A. Heasley, Susan Shelby
  • Compositions Comprising An Opioid And An Additional Active Pharmaceutical Ingredient For Rapid Onset And Extended Duration Of Analgesia That May Be Administered Without Regard To Food
    Publication number: 20140275143
    Abstract: The present disclosure provides pharmaceutical compositions comprising an opioid and an additional active pharmaceutical ingredient, wherein the composition exhibits gastric retentive properties which are achieved by a combination of a physical property of the composition and release of the opioid, wherein upon administration to a subject, the composition has at least one pharmacokinetic parameter that differs by less than about 30% when the subject is in a fasted state as compared to a fed state. The present disclosure further provides pharmaceutical composition comprising oxycodone and acetaminophen that provides a rapid onset of analgesia, and reduced levels of acetaminophen near the end of the dosing interval. Also provided are an extended release pharmaceutical composition comprising oxycodone and acetaminophen that provides reduced abuse potential.
    Type: Application
    Filed: February 24, 2014
    Publication date: September 18, 2014
    Applicant: MALLINCKRODT LLC
    Inventors: Krishna R. Devarakonda, Michael J. Giuliani, Vishal K. Gupta, Ralph A. Heasley, Susan Shelby
  • Tranexamic acid formulations
    Patent number: 8809394
    Abstract: Disclosed are modified release oral tranexamic acid formulations and methods of treatment therewith.
    Type: Grant
    Filed: July 9, 2012
    Date of Patent: August 19, 2014
    Assignee: Ferring B.V.
    Inventors: Keith A. Moore, Ralph A. Heasley, Jeffrey S. Greiwe, John W. Facemire, Jason D. Modest
  • Tranexamic acid formulations
    Patent number: 8791160
    Abstract: Disclosed are modified release oral tranexamic acid formulations and methods of treatment therewith.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: July 29, 2014
    Assignee: Ferring B.V.
    Inventors: Keith A. Moore, Ralph A. Heasley, Jeffrey S. Greiwe, John W. Facemire, Jason D. Modest
  • Gastric retentive extended release pharmaceutical compositions
    Patent number: 8790694
    Abstract: The present disclosure provides extended release pharmaceutical compositions comprising an opioid and an additional active pharmaceutical ingredient, wherein the composition exhibits gastric retentive properties which are achieved by a combination of a physical property of the composition and release of the opioid, wherein upon administration to a subject, the composition has at least one pharmacokinetic parameter that differs by less than about 30% when the subject is in a fasted state as compared to a fed state.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: July 29, 2014
    Assignee: Mallinckrodt LLC
    Inventors: Krishna R. Devarakonda, Michael J. Giuliani, Vishal K. Gupta, Ralph A. Heasley, Susan Shelby
  • COMBINATION COMPOSITION COMPRISING OXYCODONE AND ACETAMINOPHEN FOR RAPID ONSET AND EXTENDED DURATION OF ANALGESIA
    Publication number: 20140170217
    Abstract: The present disclosure provides an extended release pharmaceutical composition comprising oxycodone and acetaminophen that provides a rapid onset of analgesia, and reduced levels of acetaminophen near the end of the dosing interval. Also provided are methods for reducing the risk of acetaminophen-induced hepatic damage in a subject being treated with an acetaminophen containing composition, as well as methods for treating pain in a subject in need thereof.
    Type: Application
    Filed: December 17, 2013
    Publication date: June 19, 2014
    Applicant: MALLINCKRODT LLC
    Inventors: Krishna R. Devarakonda, Michael J. Giuliani, Vishal K. Gupta, Ralph A. Heasley, Susan Shelby
  • Gastric retentive extended release pharmaceutical compositions
    Patent number: 8741885
    Abstract: The present disclosure provides extended release pharmaceutical compositions comprising an opioid and an additional active pharmaceutical ingredient, wherein the composition exhibits gastric retentive properties which are achieved by a combination of a physical property of the composition and release of the opioid, wherein upon administration to a subject, the composition has at least one pharmacokinetic parameter that differs by less than about 30% when the subject is in a fasted state as compared to a fed state.
    Type: Grant
    Filed: May 16, 2012
    Date of Patent: June 3, 2014
    Assignee: Mallinckrodt LLC
    Inventors: Krishna Devarakonda, Michael J Guiliani, Vishal K Gupta, Ralph A Heasley, Susan Shelby
  • GASTRIC RETENTIVE EXTENDED RELEASE PHARMACEUTICAL COMPOSITIONS
    Publication number: 20140105977
    Abstract: The present disclosure provides extended release pharmaceutical compositions comprising an opioid and an additional active pharmaceutical ingredient, wherein the composition exhibits gastric retentive properties which are achieved by a combination of a physical property of the composition and release of the opioid, wherein upon administration to a subject, the composition has at least one pharmacokinetic parameter that differs by less than about 30% when the subject is in a fasted state as compared to a fed state.
    Type: Application
    Filed: December 18, 2013
    Publication date: April 17, 2014
    Applicant: MALLINCKRODT LLC
    Inventors: KRISHNA R. DEVARAKONDA, MICHAEL J. GIULIANI, VISHAL K. GUPTA, RALPH A. HEASLEY, SUSAN SHELBY
  • Combination composition comprising oxycodone and acetaminophen for rapid onset and extended duration of analgesia
    Patent number: 8658631
    Abstract: The present disclosure provides an extended release pharmaceutical composition comprising oxycodone and acetaminophen that provides a rapid onset of analgesia, and reduced levels of acetaminophen near the end of the dosing interval. Also provided are methods for reducing the risk of acetaminophen-induced hepatic damage in a subject being treated with an acetaminophen containing composition, as well as methods for treating pain in a subject in need thereof.
    Type: Grant
    Filed: May 16, 2012
    Date of Patent: February 25, 2014
    Assignee: Mallinckrodt LLC
    Inventors: Krishna Devarakonda, Michael J Guiliani, Vishal K Gupta, Ralph A Heasley, Susan Shelby
  • Tranexamic acid formulations
    Patent number: 8487005
    Abstract: Disclosed are modified release oral tranexamic acid formulations and methods of treatment therewith.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: July 16, 2013
    Assignee: Ferring B.V.
    Inventors: Keith A. Moore, Ralph A. Heasley, Jeffrey S. Greiwe, John W. Facemire, Jason D. Modest
  • Tranexamic Acid Formulations
    Publication number: 20130096198
    Abstract: Disclosed are modified release oral tranexamic acid formulations and methods of treatment therewith.
    Type: Application
    Filed: July 9, 2012
    Publication date: April 18, 2013
    Applicant: FERRING B.V.
    Inventors: Keith A. Moore, Ralph A. Heasley, Jeffrey S. Greiwe, John W. Facemire, Jason D. Modest
  • Tranexamic Acid Formulations
    Publication number: 20130018100
    Abstract: Disclosed are modified release oral tranexamic acid formulations and methods of treatment therewith.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 17, 2013
    Applicant: FERRING B.V.
    Inventors: Keith A. Moore, Ralph A. Heasley, Jeffrey S. Greiwe, John W. Facemire, Jason D. Modest
  • Tranexamic Acid Formulations
    Publication number: 20130012584
    Abstract: Disclosed are modified release oral tranexamic acid formulations and methods of treatment therewith.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 10, 2013
    Applicant: FERRING B.V.
    Inventors: Keith A. Moore, Ralph A. Heasley, Jeffrey S. Greiwe, John W. Facemire, Jason D. Modest
  • Tranexamic acid formulations
    Patent number: 8273795
    Abstract: Disclosed are modified release oral tranexamic acid formulations and methods of treatment therewith.
    Type: Grant
    Filed: August 13, 2008
    Date of Patent: September 25, 2012
    Assignee: Ferring B.V.
    Inventors: Keith A. Moore, Ralph A. Heasley, Jeffrey S. Greiwe, John W. Facemire, Jason D. Modest
  • Tranexamic Acid Formulations
    Publication number: 20120122985
    Abstract: Disclosed are modified release oral tranexamic acid formulations and methods of treatment therewith.
    Type: Application
    Filed: September 13, 2011
    Publication date: May 17, 2012
    Inventors: Keith A. Moore, Ralph A. Heasley, Jeffrey S. Greiwe, John W. Facemire, Jason D. Modest
  • Tranexamic Acid Formulations
    Publication number: 20110230559
    Abstract: Disclosed are immediate release oral tranexamic acid formulations and methods of treatment therewith.
    Type: Application
    Filed: January 28, 2011
    Publication date: September 22, 2011
    Applicant: FERRING B.V.
    Inventors: Keith A. Moore, Ralph A. Heasley, Jeffrey S. Greiwe, John W. Facemire, Jason D. Modest
  • Tranexamic acid formulations
    Patent number: 8022106
    Abstract: Disclosed are modified release oral tranexamic acid formulations and methods of treatment therewith.
    Type: Grant
    Filed: April 30, 2009
    Date of Patent: September 20, 2011
    Assignee: Ferring B.V.
    Inventors: Keith A. Moore, Ralph A. Heasley, Jeffrey S. Greiwe, John W. Facemire, Jason D. Modest
  • Tranexamic acid formulations
    Patent number: 7947739
    Abstract: Disclosed are modified release oral tranexamic acid formulations and methods of treatment therewith.
    Type: Grant
    Filed: February 26, 2010
    Date of Patent: May 24, 2011
    Assignee: Ferring B.V.
    Inventors: Keith A. Moore, Ralph A. Heasley, Jeffrey S. Greiwe, John W. Facemire, Jason D. Modest
  • Menorrhagia Instrument and Method for the Treatment of Menstrual Bleeding Disorders
    Publication number: 20100280117
    Abstract: Disclosed is a Menorrhagia Instrument and methods for the treatment of menstrual bleeding disorders.
    Type: Application
    Filed: April 29, 2010
    Publication date: November 4, 2010
    Applicant: Xanodyne Pharmaceuticals, Inc.
    Inventors: Donald Patrick, Keith A. Moore, Brian J. Ruff, Ralph A. Heasley