Patents by Inventor Ralph Hirschmann

Ralph Hirschmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antiviral phosphonate analogs
    Patent number: 9139604
    Abstract: The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: June 19, 2014
    Date of Patent: September 22, 2015
    Assignee: Gilead Sciences, Inc.
    Inventors: Constantine G. Boojamra, Carina E. Cannizzaro, James M. Chen, Xiaowu Chen, Aesop Cho, Lee S. Chong, Maria Fardis, Haolun Jin, Ralph Hirschmann, Alan X. Huang, Choung U. Kim, Thorsten A. Kirschberg, Christopher P. Lee, William A. Lee, Richard L. Mackman, David Y. Markevitch, David A. Oare, Vidya K. Prasad, Hyung-Jung Pyun, Adrian S. Ray, Rosemarie O'Shea, Sundaramoorthi Swaminathan, William J. Watkins, Jennifer R. Zhang
  • ANTIVIRAL PHOSPHONATE ANALOGS
    Publication number: 20150025039
    Abstract: The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: June 19, 2014
    Publication date: January 22, 2015
    Inventors: Constantine G. BOOJAMRA, Carina E. CANNIZZARO, James M. CHEN, Xiaowu CHEN, Aesop CHO, Lee S. CHONG, Maria FARDIS, Haolun JIN, Ralph HIRSCHMANN, Alan X. HUANG, Choung U. KIM, Thorsten A. KIRSCHBERG, Christopher P. LEE, William A. LEE, Richard L. MACKMAN, David Y. MARKEVITCH, David A. OARE, Vidya K. PRASAD, Hyung-Jung PYUN, Adrian S. RAY, Rosemarie O'SHEA, Sundaramoorthi SWAMINATHAN, William J. WATKINS, Jennifer R. ZHANG
  • Antiviral phosphonate analogs
    Patent number: 8871785
    Abstract: The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: March 21, 2013
    Date of Patent: October 28, 2014
    Assignee: Gilead Sciences, Inc.
    Inventors: Constantine G. Boojamra, Carina E. Cannizzaro, James M. Chen, Xiaowu Chen, Aesop Cho, Lee S. Chong, Maria Fardis, Haolun Jin, Ralph Hirschmann, Alan X. Huang, Choung U. Kim, Thorsten A. Kirschberg, Christopher P. Lee, William A. Lee, Richard L. Mackman, David Y. Markevitch, David A. Oare, Vidya K. Prasad, Hyung-Jung Pyun, Adrian S. Ray, Rosemarie O'Shea, Sundaramoorthi Swaninathan, William J. Watkins, Jennifer R. Zhang
  • Therapeutic phosphonate compounds
    Publication number: 20060264404
    Abstract: The invention is related to phosphorus substituted therapeutic agents, compositions containing such phosphorus substituted agents, and therapeutic methods that include the administration of such phosphorus substituted agents, as well as to processes and intermediates useful for preparing such agents.
    Type: Application
    Filed: October 25, 2005
    Publication date: November 23, 2006
    Inventors: Constantine Boojamra, Carina Cannizzaro, James Chen, Xiaowu Chen, Aesop Cho, Lee Chong, Manoj Desai, Maria Fardis, Craig Gibbs, Ralph Hirschmann, Alan Huang, Haolun Jin, Choung Kim, Thorsten Kirschberg, Steven Krawczyk, Christopher Lee, William Lee, Kuei-Ying Lin, Richard Mackman, David Markevitch, Peter Nelson, David Oare, Vidya Prasad, Hyung-Jung Pyun, Adrian Ray, Rosemarie Sherlock, Sundaramoorthi Swaminathan, William Watkins, Jennifer Zhang, Lijun Zhang
  • Anti-inflammatory phosphonate compounds
    Publication number: 20060199788
    Abstract: The invention is related to phosphorus substituted anti-inflammatory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: April 26, 2004
    Publication date: September 7, 2006
    Inventors: Carina Cannizzaro, James Chen, Xiaowu Chen, Aesop Cho, Lee Chong, Maria Fardis, Craig Gibbs, Ralph Hirschmann, Thorsten Kirschberg, Christopher Lee, Kuei-Ying Lin, Richard Mackman, Peter Nelson, David Oare, Hyung-Jung Pyun, Adrian Ray, Rosemarie Sherlock, Sundaramoorthi Swaminathan, William Watkins, Jennifer Zhang
  • Antiviral phosphonate analogs
    Publication number: 20050215513
    Abstract: The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: April 26, 2004
    Publication date: September 29, 2005
    Inventors: Constantine Boojamra, Carina Cannizzaro, James Chen, Xiaowu Chen, Aesop Cho, Lee Chong, Maria Fardis, Haolun Jin, Ralph Hirschmann, Alan Huang, Choung Kim, Thorsten Kirschberg, Christopher Lee, William Lee, Richard MacKman, David Markevitch, David Oare, Vidya Prasad, Hyung-Jung Pyun, Adrian Ray, Rosemarie Sherlock, Sundaramoorthi Swaminathan, William Watkins, Jennifer Zhang
  • Solution and solid phase synthesis of pyrrolinones and polypyrrolinones
    Publication number: 20050004371
    Abstract: The invention provides a new process for the preparation of polypyrrolinones (I) of various sizes which have found to be useful peptidomimetics. One aspect of the invention is a new process utilizing ?-amino-?-substituted-valerolactones as synthons. A second aspect of the invention is a process for the synthesis of polypyrrolinones using solid-phase techniques.
    Type: Application
    Filed: July 20, 2004
    Publication date: January 6, 2005
    Inventors: Amos Smith, Ralph Hirschmann, Hu Liu, Hiroyuki Ikumura
  • Non-peptide peptidomimetics
    Patent number: 6197963
    Abstract: Compounds are provided which are crossreactive with peptides such as those which bind G-protein-linked receptors, together with preparative and therapeutic methods therefor. The compounds have the general structure: wherein at least one of R1, R2, R3, R4, or R5 comprises a functional group which is chemically similar to that found in the peptide of interest.
    Type: Grant
    Filed: August 13, 1998
    Date of Patent: March 6, 2001
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Ralph Hirschmann, John Hynes, Jr., Maria A. Cichy-Knight, Rachel D. van Rijn, Paul A. Sprengeler, P. Grant Spoors, William C. Shakespeare, Sherrie Pietranico-Cole, Amos B. Smith, III
  • Alicyclic peptidomimetics
    Patent number: 5817879
    Abstract: Compounds are provided which are crossreactive with peptides such as those bound by G-protein-linked receptors, together with preparative and therapeutic methods therefor. The compounds have the general structure: ##STR1## wherein at least one of R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 or R.sub.6 comprises a chemical functional group which causes the compounds to be crossreactive with the peptide of interest.
    Type: Grant
    Filed: August 26, 1996
    Date of Patent: October 6, 1998
    Assignee: Trustees of the University of Pennsylvania
    Inventors: Ralph Hirschmann, Ellen Leahy, Paul Sprengeler
  • Alicyclic peptidomimetics
    Patent number: 5550251
    Abstract: Compounds are provided which are crossreactive with peptides such as those bound by G-protein-linked receptors, together with preparative and therapeutic methods therefor. The compounds have the general structure: ##STR1## wherein at least one of R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 or R.sub.6 comprises a chemical functional group which causes the compounds to be crossreactive with the peptide of interest.
    Type: Grant
    Filed: February 23, 1994
    Date of Patent: August 27, 1996
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Ralph Hirschmann, Ellen Leahy, Paul Sprengeler
  • Pyrrolinone-based compounds
    Patent number: 5489692
    Abstract: Novel pyrrolinone-based compounds mimic or inhibit the biological and/or chemical activity of peptides, including peptide .beta.-strand conformations. Certain compounds contain functionalized pyrrolinone units in place of one or more amino acids of a target peptide.
    Type: Grant
    Filed: February 17, 1993
    Date of Patent: February 6, 1996
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Ralph Hirschmann, Amos B. Smith, III, Paul Sprengeler, Ryan C. Holcomb, Terence Keenan, John L. Wood, Mark Guzman
  • Aromatic peptidomimetics
    Patent number: 5250564
    Abstract: Compounds are provided which are crossreactive with peptides such as those bound by G-protein-linked receptors, together with preparative and therapeutic methods therefor. The compounds have the general structure: ##STR1## wherein at least one of R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 or R.sub.6 comprises a chemical functional group which causes the compounds to be crossreactive with the peptide of interest.
    Type: Grant
    Filed: December 12, 1991
    Date of Patent: October 5, 1993
    Assignee: Trustees of the University of Pennsylvania
    Inventors: Ralph Hirschmann, Ellen Leahy, Paul Sprengeler