Patents by Inventor Ralph J. Bernacki

Ralph J. Bernacki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fluorinated glucosamine analogs useful for modulating post-translational glycosylations on cells
    Patent number: 7098195
    Abstract: The present invention provides compositions and methods for inhibiting cell migration, e.g., lymphocytes and inflammation. The invention also provides an improved process for preparing fluorinated N-acetylglucosamines.
    Type: Grant
    Filed: November 26, 2002
    Date of Patent: August 29, 2006
    Assignees: Health Research, Inc., The Brigham and Women's Hospital, Inc.
    Inventors: Robert Sackstein, Charles J. Dimitroff, Ralph J. Bernacki, Moheswar Sharma, Khushi L. Matta, Brajeswar Paul
  • Fluorinated glucosamine analogs useful for modulating post-translational glycosylations on cells
    Publication number: 20030148997
    Abstract: The present invention provides compositions and methods for inhibiting cell migration, e.g., lymphocytes and inflammation. The invention also provides an improved process for preparing fluorinated N-acetylglucosamines.
    Type: Application
    Filed: November 26, 2002
    Publication date: August 7, 2003
    Inventors: Robert Sackstein, Charles J. Dimitroff, Ralph J. Bernacki, Moheswar Sharma, Khushi L. Matta, Brajeswar Paul
  • Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
    Patent number: 5811452
    Abstract: The present invention is directed to novel taxoids possessing strong reversing activities for drug-resistance associated with anti-cancer agents, the preparation of these reversal agents and pharmaceutical compositions thereof. The new taxoids of the present invention have the formula (I).
    Type: Grant
    Filed: January 8, 1997
    Date of Patent: September 22, 1998
    Assignees: The Research Foundation of State University of New York, Health Research Inc
    Inventors: Iwao Ojima, Ralph J. Bernacki
  • 2-substituted arabinopyranosyl nucleosides and nucleotides
    Patent number: 4918056
    Abstract: Novel arabinopyranosyl nucleoside derivatives having the heterocyclic moiety and fluorine at the 2' position of the sugar ring (pyranose configuration), which have antitumor, antiviral and antimicrobial properties, are prepared by condensation of a pyrimidine, purine or 1,3-oxazine base with an acylated 2-deoxy-2,2-difluoro-D-arabinopyranoside and/or acylated 2-deoxy-2-bromo-2-fluoro-D-arabinopyranoside.
    Type: Grant
    Filed: October 14, 1986
    Date of Patent: April 17, 1990
    Assignee: Health Research, Inc. (Roswell Park Division)
    Inventors: Miroslav V. Bobek, Seung-Ho An, Ralph J. Bernacki