Patents by Inventor Ralph J. Stolle
Ralph J. Stolle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 6054124Abstract: An immune suppressive product prepared by injecting an allergen or a mixture of allergens into the body of milk-producing species. Said product being the milk or a polypeptide subfraction of milk obtained from the allergen treated host. The immune suppressive product(s) is milk and or the polypeptide fractions contained therein, which is ostensively free of the intact allergen or allergens used for the treatment of the host. The immune suppressive factor(s) being a subfraction of the allergen used for the treatment. A method of preparing immune suppressive polypeptides from intact allergens, which involves injection of the specific intact allergens into a milk-producing species, collecting the immune suppressive polypeptide fractions of the intact allergens from the milk of the treated host. The immune suppressive milk containing said polypeptide fractions, and/or the polypeptide fractions obtained from said milk, are nonreactive in animals and humans as allergens.Type: GrantFiled: December 30, 1991Date of Patent: April 25, 2000Assignee: Stolle Milk Biologics, Inc.Inventors: Lee R. Beck, Ralph J. Stolle
-
Patent number: 5932250Abstract: The present invention is directed to the treatment of vascular disorders particularly arteriosclerosis and atherosclerosis in warm-blooded animals. The invention encompasses the ingestion, by warm-blooded animals, of eggs or egg fractions derived from female avians that have been hyperimmunized with specific bacterial antigens or groups of bacterial antigens. The invention is directed to methods of controlling cholesterol levels, lipid deposits, and the development of atheromatous lesions in warm-blooded animals by the ingestion of eggs or fractions thereof produced in female avians hyperimmunized with specific bacterial antigens. The invention is also directed to methods of producing the eggs and to vaccines for hyperimmunization of the female avians.Type: GrantFiled: June 7, 1995Date of Patent: August 3, 1999Assignee: DCV, Inc.Inventors: Ralph J. Stolle, Lee R. Beck
-
Patent number: 5863561Abstract: An immune suppressive product prepared by injecting an allergen or a mixture of allergens into the body of milk-producing species. Said product being the milk or a polypeptide subfraction of milk obtained from the allergen treated host. The immune suppressive product(s) is milk and or the polypeptide fractions contained therein, which is ostensively free of the intact allergen or allergens used for the treatment of the host. The immune suppressive factor(s) being a subfraction of the allergen used for the treatment. A method of preparing immune suppressive polypeptides from intact allergens, which involves injection of the specific intact allergens into a milk-producing species, collecting the immune suppressive polypeptide fractions of the intact allergens from the milk of the treated host. The immune suppressive milk containing said polypeptide fractions, and/or the polypeptide fractions obtained from said milk, are nonreactive in animals and humans as allergens.Type: GrantFiled: June 2, 1995Date of Patent: January 26, 1999Assignee: Stolle Research & Development CorporationInventors: Lee R. Beck, Ralph J. Stolle
-
Patent number: 5853765Abstract: The present invention is directed to the treatment of vascular disorders particularly arteriosclerosis and atherosclerosis in warm-blooded animals. The invention encompasses the ingestion, by warm-blooded animals, of eggs or egg fractions derived from female avians that have been hyperimmunized with specific bacterial antigens or groups of bacterial antigens. The invention is directed to methods of controlling cholesterol levels, lipid deposits, and the development of atheromatous lesions in warm-blooded animals by the ingestion of eggs or fractions thereof produced in female avians hyperimmunized with specific bacterial antigens. The invention is also directed to methods of producing the eggs and to vaccines for hyperimmunization of the female avians.Type: GrantFiled: June 7, 1995Date of Patent: December 29, 1998Assignee: DCV, Inc.Inventors: Ralph J. Stolle, Lee R. Beck
-
Patent number: 5849349Abstract: Eggs that affect lipid and cholesterol levels obtained from avian species that are hyperimmunized against a variety of bacterial antigens are disclosed. These eggs are useful as a dietary supplement for humans and other animals.Type: GrantFiled: June 7, 1995Date of Patent: December 15, 1998Assignee: DCV, Inc.Inventors: Ralph J. Stolle, Lee R. Beck
-
Patent number: 5814345Abstract: An immune suppressive product prepared by injecting an allergen or a mixture of allergens into the body of milk-producing species. Said product being the milk or a polypeptide subfraction of milk obtained from the allergen treated host. The immune suppressive product(s) is milk and or the polypeptide fractions contained therein, which is ostensively free of the intact allergen or allergens used for the treatment of the host. The immune suppressive factor(s) being a subfraction of the allergen used for the treatment. A method of preparing immune suppressive polypeptides from intact allergens, which involves injection of the specific intact allergens into a milk-producing species, collecting the immune suppressive polypeptide fractions of the intact allergens from the milk of the treated host. The immune suppressive milk containing said polypeptide fractions, and/or the polypeptide fractions obtained from said milk, are nonreactive in animals and humans as allergens.Type: GrantFiled: June 21, 1995Date of Patent: September 29, 1998Assignee: Stolle Research & Development CorporationInventors: Lee R. Beck, Ralph J. Stolle
-
Patent number: 5753268Abstract: Anti-cholesterolemic eggs are disclosed, said eggs being obtained from animals hyperimmunized against at least one anti-cholesterolemic antigen. A vaccine producing said anti-cholesterblemic egg is disclosed, said vaccine comprising at least one anti-cholesterolemic antigen. Further, a dietary supplement for humans and other animals which does not elevate serum lipid, concentrations is disclosed, said supplement comprising the anti-cholesterolemic eggs or fractions thereof. A method for treating vascular disorders in humans and other animals is also disclosed which comprises administering to said subjects said anti-cholesterolemic eggs for a time and in amounts sufficient to produce anti-arteriosclerotic effects, anti-aging vascular effects, and/or serum lipid-lowering effects.Type: GrantFiled: February 15, 1991Date of Patent: May 19, 1998Assignee: DCV Biologics, L.P.Inventors: Ralph J. Stolle, Lee R. Beck
-
Patent number: 5538727Abstract: Anti-cholesterolemic eggs are disclosed, said eggs being obtained from animals hyperimmunized against at least one anti-cholesterolemic antigen. A vaccine producing said anti-cholesterolemic egg is disclosed, said vaccine comprising at least one anti-cholesterolemic antigen. Further, a dietary supplement for humans and other animals which does not elevate serum lipid concentrations is disclosed, said supplement comprising the anti-cholesterolemic eggs or fractions thereof. A method for treating vascular disorders in humans and other animals is also disclosed which comprises administering to said subjects said anti-cholesterolemic eggs for a time and in amounts sufficient to produce anti-arteriosclerotic effects, anti-aging vascular effects, and/or serum lipid-lowering effects.Type: GrantFiled: June 10, 1992Date of Patent: July 23, 1996Assignee: DCV Biologics, L.P.Inventors: Ralph J. Stolle, Lee R. Beck
-
Patent number: 5215746Abstract: Anti-cholesterolemic eggs are disclosed, said eggs being obtained from animals hyperimmunized against at least one anti-cholesterolemic antigen. A vaccine producing said anti-cholesterolemic egg is disclosed, said vaccine comprising at least one anti-cholesterolemic antigen. Further, a dietary supplement for humans and other animals which does not elevate serum lipid concentrations is disclosed, said supplement comprising the anti-cholesterolemic eggs or fractions thereof. A method for treating vascular disorders in humans and other animals is also disclosed which comprises administering to said subjects said anti-cholesterolemic eggs for a time and in amounts sufficient to produce anti-arteriosclerotic effects, anti-aging vascular effects, and/or serum lipid-lowering effects.Type: GrantFiled: February 15, 1991Date of Patent: June 1, 1993Assignee: Stolle Research and Development CorporationInventors: Ralph J. Stolle, Lee R. Beck
-
Patent number: 5198214Abstract: A process for the production of a polyvalent vaccine effective in the prevention and treatment of mastitis in bovine animals is disclosed, which comprises periodically culturing the milk of animals exhibiting preclinical mastitis to cultivate any pathogens present therein, killing those pathogens and incorporating each strain of cultivated, killed pathogen in a pharmacological carrier together with all other strains previously identified. The process is repeated to ensure all newly appearing pathogenic strains are vaccinated against. The vaccine so produced has been demonstrated to be effective in reversal of hard udder syndrome.Type: GrantFiled: March 18, 1988Date of Patent: March 30, 1993Assignee: Stolle Research & Development CorporationInventors: Ralph J. Stolle, Lee R. Beck
-
Patent number: 5194255Abstract: The invention relates to a method for inducing the production of a milk anti-hypertensive factor in an animal, to a method for the isolation of said factor from the milk of said animal in a substantially pure form, and to the use of said factor to treat hypertension in humans and other animals, and to compositions containing the anti-hypertensive factor.Type: GrantFiled: November 6, 1989Date of Patent: March 16, 1993Assignee: Stolle Research & Development CorporationInventors: Lee R. Beck, Ralph J. Stolle
-
Patent number: 5130128Abstract: Anti-honey food products are disclosed, such food products being obtained from animals hyperimmunized against at least one antigen found in honey, and preferably whole unfractionated honey. A vaccine producing said anti-honey food product is disclosed, said vaccine comprising at least one honey antigen and preferably whole unfractionated honey. Further, a dietary supplement for humans and especially infants which protects against harmful allergens and microorganisms found in honey is disclosed, said supplement comprising the anti-honey eggs or milk or fractions thereof.Type: GrantFiled: November 6, 1989Date of Patent: July 14, 1992Assignee: Stolle Research & Development CorporationInventor: Ralph J. Stolle
-
Patent number: 4897265Abstract: A method for treating vascular disorders or pulmonary disorders associated with smoking in an animal which comprises: administering to the animal milk collected from a bovid being maintained in a hyperimmune state, in an amount and for a time sufficient to produce anti arteriosclerotic or antiaging vascular effects or sparing effects on lung tissue.Type: GrantFiled: January 9, 1987Date of Patent: January 30, 1990Assignee: Stolle Research & Development CorporationInventors: Ralph J. Stolle, Lee R. Beck
-
Patent number: 4879110Abstract: The invention relates to a method for inducing the production of a milk anti-hypertensive factor in an animal, to a method for the isolation of said factor from the milk of said animal in a substantially pure form, and to the use of said factor to treat hypertension in humans and other animals.Type: GrantFiled: February 26, 1988Date of Patent: November 7, 1989Assignee: Stolle Research and Development CorporationInventors: Lee R. Beck, Ralph J. Stolle
-
Patent number: 4762712Abstract: A process for the production of a polyvalent vaccine effective in the prevention and treatment of mastitis in bovine animals is disclosed, which comprises periodically culturing the milk of animals exhibiting preclinical mastitis to cultivate any pathogens present therein, killing those pathogens and incorporating each strain of cultivated, killed pathogen in a pharmacological carrier together with all other strains previously identified. The process is repeated to ensure all newly appearing pathogenic strains are vaccinated against. The vaccine so produced has been demonstated to be effective in reversal of hard udder syndrome.Type: GrantFiled: August 31, 1983Date of Patent: August 9, 1988Assignee: Stolle Research & Development CorporationInventors: Ralph J. Stolle, Lee R. Beck
-
Patent number: 4748018Abstract: A method of passively immunizing a mammal against a condition caused by an antigen comprising: administering to the mammal immunizing amounts of an antibody obtained from a domesticated fowl which has been immunized against the antigen; the mammal being tolerant to the antibody by virtue of having a history of consumption of antibody containing material derived from the egg of a fowl.Type: GrantFiled: June 19, 1984Date of Patent: May 31, 1988Assignee: Stolle Research & Development Corp.Inventors: Ralph J. Stolle, Lee R. Beck
-
Patent number: 4732757Abstract: There is disclosed a novel method and product for the treatment and prevention of rheumatoid arthritis. The method involves passive immunization against a mixed spectrum of infectious bacteria which reside in the human gastrointestinal tract. The passive immunization is accomplished by oral injestion of IgG immunoglobulin obtained from the milk of cows that have been immunized against a specific spectrum of bacterial types. A unique combination of bacterial species is formulated into a vaccine which is used to immunize dairy cattle. The IgG antibody obtained from the milk of the immunized cows constitutes the product of the invention.Type: GrantFiled: December 9, 1983Date of Patent: March 22, 1988Assignee: Stolle Research and Development CorporationInventors: Ralph J. Stolle, Lee R. Beck
-
Patent number: 4636384Abstract: A method for treating vascular disorders or pulmonary disorders associated with smoking in an animal which comprises: adminstering to the animal milk collected from a bovid being maintained in a hyperimmune state, in an amount and for a time sufficient to produce anti arteriosclerotic or antiaging vascular effects or sparing effects on lung tissue.Type: GrantFiled: October 27, 1983Date of Patent: January 13, 1987Assignee: Stolle Research & Development CorporationInventors: Ralph J. Stolle, Lee R. Beck
-
Patent number: RE33403Abstract: A method for treating vascular disorders or pulmonary disorders associated with smoking in an animal which comprises: adminstering to the animal milk collected from a bovid being maintained in a hyperimmune state, in an amount and for a time sufficient to produce anti arteriosclerotic or antiaging vascular effects or sparing effects on lung tissue.Type: GrantFiled: January 13, 1989Date of Patent: October 23, 1990Assignee: Stolle Research & Development CorporationInventors: Ralph J. Stolle, Lee R. Beck
-
Patent number: RE33565Abstract: There is disclosed a novel method and product for the treatment and prevention of rheumatoid arthritis. The method involves passive immunization against a mixed spectrum of infectious bacteria which reside in the human gastrointestinal tract. The passive immunization is accomplished by oral.[.injestion.]. .Iadd.ingestion .Iaddend.of IgG immunoglobulin obtained from the milk of cows that have been immunized against a specific spectrum of bacterial types. A unique combination of bacterial species is formulated into a vaccine which is used to immunize dairy cattle. The IgG antibody obtained from the milk of the immunized cows constitutes the product of the invention.Type: GrantFiled: August 11, 1988Date of Patent: April 2, 1991Assignee: Stolle Research and Development CorporationInventors: Ralph J. Stolle, Lee R. Beck