Patents by Inventor Ralph J. ZITNIK
Ralph J. ZITNIK has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11964150Abstract: Methods and apparatuses (e.g., devices and systems) for vagus nerve stimulation, including (but not limited to) sub-diaphragmatic vagus nerve stimulation. In particular, the methods and apparatuses described herein may be used to stimulate the posterior sub-diaphragmatic vagus nerve to treat inflammation and/or inflammatory disorders. The implantable microstimulators described herein may be leadless and batteryless.Type: GrantFiled: July 27, 2022Date of Patent: April 23, 2024Assignee: SetPoint Medical CorporationInventors: Ralph J. Zitnik, Michael A. Faltys, Jacob A. Levine, Jesse M. Simon
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Patent number: 11890471Abstract: Diagnostic screening tests that can be used to identify if a patient is a good candidates for an implantable vagus nerve stimulation device. One or more analyte, such as a cytokine or inflammatory molecule, can be measured from a blood sample taken prior to implantation of a vagus nerve stimulator to determine the patient's responsiveness to VNS for treatment of an inflammatory disorder.Type: GrantFiled: October 20, 2021Date of Patent: February 6, 2024Assignee: SetPoint Medical CorporationInventors: Jacob A. Levine, Ralph J. Zitnik
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Publication number: 20220362555Abstract: Methods and apparatuses (e.g., devices and systems) for vagus nerve stimulation, including (but not limited to) sub-diaphragmatic vagus nerve stimulation. In particular, the methods and apparatuses described herein may be used to stimulate the posterior sub-diaphragmatic vagus nerve to treat inflammation and/or inflammatory disorders. The implantable microstimulators described herein may be leadless and batteryless.Type: ApplicationFiled: July 27, 2022Publication date: November 17, 2022Inventors: Ralph J. ZITNIK, Michael A. FALTYS, Jacob A. LEVINE, Jesse M. SIMON
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Patent number: 11471681Abstract: Methods and apparatuses (e.g., devices and systems) for vagus nerve stimulation, including (but not limited to) sub-diaphragmatic vagus nerve stimulation. In particular, the methods and apparatuses described herein may be used to stimulate the posterior sub-diaphragmatic vagus nerve to treat inflammation and/or inflammatory disorders. The implantable microstimulators described herein may be leadless and batteryless.Type: GrantFiled: March 18, 2019Date of Patent: October 18, 2022Assignee: SetPoint Medical CorporationInventors: Ralph J. Zitnik, Michael A. Faltys, Jacob A. Levine, Jesse M. Simon
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Publication number: 20220040483Abstract: Diagnostic screening tests that can be used to identify if a patient is a good candidates for an implantable vagus nerve stimulation device. One or more analyte, such as a cytokine or inflammatory molecule, can be measured from a blood sample taken prior to implantation of a vagus nerve stimulator to determine the patient's responsiveness to VNS for treatment of an inflammatory disorder.Type: ApplicationFiled: October 20, 2021Publication date: February 10, 2022Inventors: Jacob A. LEVINE, Ralph J. ZITNIK
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Patent number: 11173307Abstract: Diagnostic screening tests that can be used to identify if a patient is a good candidates for an implantable vagus nerve stimulation device. One or more analyte, such as a cytokine or inflammatory molecule, can be measured from a blood sample taken prior to implantation of a vagus nerve stimulator to determine the patient's responsiveness to VNS for treatment of an inflammatory disorder.Type: GrantFiled: August 14, 2018Date of Patent: November 16, 2021Assignee: SetPoint Medical CorporationInventors: Jacob A. Levine, Ralph J. Zitnik
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Patent number: 10449358Abstract: Devices and methods for stimulation of the vagus nerve to modulate (e.g., reduce, suppress, etc.) bone erosion. Methods and apparatus for modulating bone erosion may modulate levels of Receptor Activator for Nuclear Factor ?B Ligand (RANKL), and/or to modulate (increase, enhance, etc.) osteoprotegerin (OPG) and/or OPG/RANKL ratio. Devices may include electrical stimulation devices that may be implanted, and may be activated to apply current for a proscribed duration, followed by a period without stimulation.Type: GrantFiled: January 4, 2017Date of Patent: October 22, 2019Assignee: SetPoint Medical CorporationInventors: Jacob A. Levine, Michael A. Faltys, Ralph J. Zitnik
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Publication number: 20190275328Abstract: Methods and apparatuses (e.g., devices and systems) for vagus nerve stimulation, including (but not limited to) sub-diaphragmatic vagus nerve stimulation. In particular, the methods and apparatuses described herein may be used to stimulate the posterior sub-diaphragmatic vagus nerve to treat inflammation and/or inflammatory disorders. The implantable microstimulators described herein may be leadless and batteryless.Type: ApplicationFiled: March 18, 2019Publication date: September 12, 2019Inventors: Ralph J. ZITNIK, Michael A. FALTYS, Jacob A. LEVINE, Jesse M. SIMON
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Patent number: 10314501Abstract: Methods and apparatuses (e.g., devices and systems) for vagus nerve stimulation, including (but not limited to) sub-diaphragmatic vagus nerve stimulation. In particular, the methods and apparatuses described herein may be used to stimulate the posterior sub-diaphragmatic vagus nerve to treat inflammation and/or inflammatory disorders. The implantable microstimulators described herein may be inductively charged and/or communicated with using the external charger. The implant may include a receiving antenna wrapped around the battery and/or the housing of the microstimulator/microregulator and/or may include a high magnetic permeability material in order to serve as a magnetic core for the antenna coil. Wearable inductive chargers/communication devices for inductively communicating with (including charging) an implanted microstimulator are described herein, which may include magnetically conductive material to enhance communication with an implant, including sub-diaphragmatic implants.Type: GrantFiled: January 20, 2017Date of Patent: June 11, 2019Assignee: SetPoint Medical CorporationInventors: Ralph J. Zitnik, Michael A. Faltys, Jacob A. Levine, Jesse M. Simon
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Publication number: 20190046799Abstract: Diagnostic screening tests that can be used to identify if a patient is a good candidates for an implantable vagus nerve stimulation device. One or more analyte, such as a cytokine or inflammatory molecule, can be measured from a blood sample taken prior to implantation of a vagus nerve stimulator to determine the patient's responsiveness to VNS for treatment of an inflammatory disorder.Type: ApplicationFiled: August 14, 2018Publication date: February 14, 2019Inventors: Jacob A. LEVINE, Ralph J. ZITNIK
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Publication number: 20170202467Abstract: Methods and apparatuses (e.g., devices and systems) for vagus nerve stimulation, including (but not limited to) sub-diaphragmatic vagus nerve stimulation. In particular, the methods and apparatuses described herein may be used to stimulate the posterior sub-diaphragmatic vagus nerve to treat inflammation and/or inflammatory disorders. The implantable microstimulators described herein may be inductively charged and/or communicated with using the external charger. The implant may include a receiving antenna wrapped around the battery and/or the housing of the microstimulator/microregulator and/or may include a high magnetic permeability material in order to serve as a magnetic core for the antenna coil. Wearable inductive chargers/communication devices for inductively communicating with (including charging) an implanted microstimulator are described herein, which may include magnetically conductive material to enhance communication with an implant, including sub-diaphragmatic implants.Type: ApplicationFiled: January 20, 2017Publication date: July 20, 2017Inventors: Ralph J. ZITNIK, Michael A. FALTYS, Jacob A. LEVINE, Jesse M. SIMON
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Patent number: 9662490Abstract: Described herein are devices, systems and method of treating inflammation by vagus nerve stimulation and the delivery of an anti-inflammatory drug. In particular, described herein are methods of treating inflammation including the steps of stimulating a subject's inflammatory reflex to inhibit the immune response and administering an anti-inflammatory drug.Type: GrantFiled: December 11, 2015Date of Patent: May 30, 2017Assignee: The Feinstein Institute for Medical ResearchInventors: Kevin J. Tracey, Mauricio Rosas-Ballina, Michael A. Faltys, Ralph J. Zitnik
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Publication number: 20170113044Abstract: Devices and methods for stimulation of the vagus nerve to modulate (e.g., reduce, suppress, etc.) bone erosion. Methods and apparatus for modulating bone erosion may modulate levels of Receptor Activator for Nuclear Factor ?B Ligand (RANKL), and/or to modulate (increase, enhance, etc.) osteoprotegerin (OPG) and/or OPG/RANKL ratio. Devices may include electrical stimulation devices that may be implanted, and may be activated to apply current for a proscribed duration, followed by a period without stimulation.Type: ApplicationFiled: January 4, 2017Publication date: April 27, 2017Inventors: Jacob A. LEVINE, Michael A. FALTYS, Ralph J. ZITNIK
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Patent number: 9572983Abstract: Devices and methods for stimulation of the vagus nerve to modulate (e.g., reduce, suppress, etc.) bone erosion. Methods and apparatus for modulating bone erosion may modulate levels of Receptor Activator for Nuclear Factor ? B Ligand (RANKL), and/or to modulate (increase, enhance, etc.) osteoprotegerin (OPG) and/or OPG/RANKL ratio. Devices may include electrical stimulation devices that may be implanted, and may be activated to apply current for a proscribed duration, followed by a period without stimulation.Type: GrantFiled: March 26, 2013Date of Patent: February 21, 2017Assignee: SetPoint Medical CorporationInventors: Jacob A. Levine, Michael A. Faltys, Ralph J. Zitnik
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Publication number: 20160096016Abstract: Described herein are devices, systems and method of treating inflammation by vagus nerve stimulation and the delivery of an anti-inflammatory drug. In particular, described herein are methods of treating inflammation including the steps of stimulating a subject's inflammatory reflex to inhibit the immune response and administering an anti-inflammatory drug.Type: ApplicationFiled: December 11, 2015Publication date: April 7, 2016Inventors: Kevin J. TRACEY, Mauricio ROSAS-BALLINA, Michael A. FALTYS, Ralph J. ZITNIK
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Publication number: 20150241447Abstract: A diagnostic screening test can be used to identify candidates for implantable vagus nerve stimulation devices. An analyte, such as a cytokine or inflammatory molecule, can be measured both before and after vagus nerve stimulation in order to determine the responsiveness of the patient. VNS can be delivered noninvasively or minimally invasively using short term electrical or mechanical stimulation.Type: ApplicationFiled: February 24, 2015Publication date: August 27, 2015Inventors: Ralph J. Zitnik, Jacob A. Levine
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Publication number: 20130253413Abstract: Devices and methods for stimulation of the vagus nerve to modulate (e.g., reduce, suppress, etc.) bone erosion. Methods and apparatus for modulating bone erosion may modulate levels of Receptor Activator for Nuclear Factor ?B Ligand (RANKL), and/or to modulate (increase, enhance, etc.) osteoprotegerin (OPG) and/or OPG/RANKL ratio. Devices may include electrical stimulation devices that may be implanted, and may be activated to apply current for a proscribed duration, followed by a period without stimulation.Type: ApplicationFiled: March 26, 2013Publication date: September 26, 2013Inventors: Jacob A. LEVINE, Michael A. FALTYS, Ralph J. ZITNIK
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Publication number: 20110054569Abstract: Described herein are devices, including interface modules or prescription pads, and systems including these devices and methods of using them, for treating inflammation or inflammatory disorders, and particularly for interfacing with a user desiring to prescribe treatment of an inflammatory disorder using an implanted stimulator.Type: ApplicationFiled: September 1, 2010Publication date: March 3, 2011Inventors: Ralph J. ZITNIK, Michael A. Faltys