Patents by Inventor Ralph Kubo

Ralph Kubo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inducing Cellular Immune Responses to Hepatitis B Virus Using Peptide and Nucleic Acid Compositions
    Publication number: 20100068228
    Abstract: This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to develop epitope-based vaccines directed towards HBV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HBV infection.
    Type: Application
    Filed: August 5, 2009
    Publication date: March 18, 2010
    Applicant: Pharmexa Inc.
    Inventors: Alessandro SETTE, John Sidney, Scott Southwood, Maria Vitiello, Brian Livingston, Esteban Celis, Ralph Kubo, Howard Grey, Robert Chesnut
  • Inducing cellular immune responses to hepatitis B virus using peptide compositions
    Patent number: 7611713
    Abstract: This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to develop epitope-based vaccines directed towards HBV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HBV infection.
    Type: Grant
    Filed: September 4, 2003
    Date of Patent: November 3, 2009
    Assignee: Pharmexa Inc.
    Inventors: Alessandro Sette, John Sidney, Scott Southwood, Maria Vitiello, Brian Livingston, Esteban Celis, Ralph Kubo, Howard Grey, Robert Chesnut
  • Inducing cellular immune responses to hepatitis B virus using peptide and nucleic acid compositions
    Publication number: 20070059799
    Abstract: This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to develop epitope-based vaccines directed towards HBV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HBV infection.
    Type: Application
    Filed: September 18, 2006
    Publication date: March 15, 2007
    Applicant: Pharmexa Inc.
    Inventors: Alessandro Sette, John Sidney, Scott Southwood, Maria Vitiello, Brian Livingston, Esteban Celis, Ralph Kubo, Howard Grey, Robert Chesnut
  • HLA binding motifs and peptides and their uses
    Publication number: 20070055049
    Abstract: The present invention provides the means and methods for selecting immunogenic peptides and the immunogenic peptide compositions capable of specifically binding glycoproteins encoded by HLA alleles and inducing T cell activation in T cells restricted by the allele. The peptides are useful to elicit an immune response against a desired antigen.
    Type: Application
    Filed: April 6, 2004
    Publication date: March 8, 2007
    Inventors: Howard Grey, Alessandro Sette, John Sidney, Scott Southwood, Ralph Kubo, Esteban Celis, Robert Chesnut, W. Kast
  • Inducing cellular immune responses to human immunodeficiency virus-1 using peptide and nucleic acid compositions
    Publication number: 20050271676
    Abstract: This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to identify and prepare human immunodeficiency virus (HIV) epitopes, and to develop epitope-based vaccines directed towards HIV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HIV infection.
    Type: Application
    Filed: January 28, 2005
    Publication date: December 8, 2005
    Inventors: Alessandro Sette, John Sidney, Scott Southwood, Brian Livingston, Robert Chesnut, Denise Baker, Esteban Celis, Ralph Kubo, Howard Grey
  • Inducing cellular immune responses to hepatitis B virus using peptide and nucleic acid compositions
    Publication number: 20050063983
    Abstract: This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to develop epitope-based vaccines directed towards HBV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HBV infection.
    Type: Application
    Filed: September 4, 2003
    Publication date: March 24, 2005
    Inventors: Alessandro Sette, John Sidney, Scott Southwood, Maria Vitiello, Brian Livingston, Esteban Celis, Ralph Kubo, Howard Grey, Robert Chesnut
  • Methods for ex vivo therapy using peptide-loaded antigen presenting cells for the activation of CTL
    Patent number: 5846827
    Abstract: Methods for activating cytotoxic T lymphocytes (CTL) in vitro are presented in conjunction with methods for using the activated CTL for therapy in vivo. Additionally, a method for killing specific CTL in vivo is presented using antigen presenting cells which were modified in vitro.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 8, 1998
    Assignee: Cytel Corporation
    Inventors: Esteban Celis, Ralph Kubo, Horacio Serra, Van Tsai, Peggy Wentworth