Patents by Inventor Ralph L. McDade

Ralph L. McDade has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210223267
    Abstract: Methods and devices for diagnosing, monitoring, or determining diabetic nephropathy or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining diabetic nephropathy or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.
    Type: Application
    Filed: March 8, 2021
    Publication date: July 22, 2021
    Applicant: MYRIAD RBM, INC.
    Inventors: Samuel T. LaBrie, James P. Mapes, Ralph L. McDade, Dominic Eisinger, Karri L. Ballard, Michael D. SPAIN
  • Publication number: 20170370947
    Abstract: Methods and devices for diagnosing, monitoring, or determining diabetic nephropathy or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining diabetic nephropathy or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.
    Type: Application
    Filed: August 11, 2017
    Publication date: December 28, 2017
    Inventors: Samuel T. LaBrie, James P. Mapes, Ralph L. McDade, Dominic Eisinger, Karri L. Ballard
  • Publication number: 20160231332
    Abstract: Methods and devices for diagnosing, monitoring, or determining kidney damage in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining kidney damage using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.
    Type: Application
    Filed: February 3, 2016
    Publication date: August 11, 2016
    Inventors: Samuel T. LaBrie, James P. Mapes, Michael D. Spain, Ralph L. McDade, Dominic P. Eisinger, Karri L. Ballard
  • Publication number: 20150276765
    Abstract: Methods and devices for diagnosing, monitoring, or determining diabetic nephropathy or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining diabetic nephropathy or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.
    Type: Application
    Filed: March 10, 2015
    Publication date: October 1, 2015
    Inventors: Samuel T. LaBrie, James P. Mapes, Ralph L. McDade, Dominic Eisinger, Karri L. Ballard
  • Publication number: 20140303021
    Abstract: Methods and devices for diagnosing, monitoring, or determining obstructive uropathy or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining obstructive uropathy or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.
    Type: Application
    Filed: April 2, 2014
    Publication date: October 9, 2014
    Inventors: Samuel T. LaBrie, James P. Mapes, Michael D. Spain, Ralph L. McDade, Dominic P. Eisinger, Karri L. Ballard
  • Publication number: 20140147863
    Abstract: Methods and devices for predicting, diagnosing, monitoring, or determining Alzheimer's disease in a human are described. In particular, methods and devices for predicting diagnosing, monitoring, or determining AD using measured concentrations of a combination of three or more analytes in a test sample taken from the human are described.
    Type: Application
    Filed: May 13, 2011
    Publication date: May 29, 2014
    Applicant: RULES-BASED MEDICINE, INC.
    Inventors: Sidney E O'Bryant, Robert Clinton Barber, Ramon Diaz-Arrastia, Guanghua Xiao, Peirrie Milton Adams, Joan Snavely Reisch, Rachelle Smith Doody, Thomas John Fairchild, Ralph L. McDade, Samuel T. Labrie
  • Patent number: 8735080
    Abstract: Methods and devices for diagnosing, monitoring, or determining obstructive uropathy or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining obstructive uropathy or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.
    Type: Grant
    Filed: August 6, 2010
    Date of Patent: May 27, 2014
    Assignee: Rules-Based Medicine, Inc.
    Inventors: Samuel T. Labrie, James P. Mapes, Ralph L. McDade, Dominic Eisinger, Karri L. Ballard, Michael D. Spain
  • Publication number: 20110177959
    Abstract: Methods and devices for diagnosing, monitoring, or determining kidney transplant rejection or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining kidney transplant rejection or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.
    Type: Application
    Filed: August 6, 2010
    Publication date: July 21, 2011
    Applicant: Rules-Based Medicine, Inc.
    Inventors: Michael D. Spain, James P. Mapes, Samuel T. Labrie, Ralph L. McDade, Dominic P. Eisinger, Karri L. Ballard, Daniel R. Salomon, Michael Abecassis
  • Publication number: 20110065599
    Abstract: Methods and devices for diagnosing, monitoring, or determining kidney damage in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining kidney damage using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.
    Type: Application
    Filed: August 6, 2010
    Publication date: March 17, 2011
    Applicant: Rules-Based Medicine, Inc.
    Inventors: Samuel T. LaBrie, James P. Mapes, Ralph L. McDade, Dominic Eisinger, Karri L. Ballard, Michael D. Spain
  • Publication number: 20110065593
    Abstract: Methods and devices for diagnosing, monitoring, or determining a renal disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining a renal disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.
    Type: Application
    Filed: August 6, 2010
    Publication date: March 17, 2011
    Applicant: Rules-Based Medicine, Inc.
    Inventors: Samuel T. Labrie, James P. Mapes, Ralph L. McDade, Dominic Eisinger, Karri L. Ballard, Michael D. Spain
  • Publication number: 20110065137
    Abstract: Methods and devices for diagnosing, monitoring, or determining obstructive uropathy or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining obstructive uropathy or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.
    Type: Application
    Filed: August 6, 2010
    Publication date: March 17, 2011
    Applicant: Rules-Based Medicine, Inc.
    Inventors: Samuel T. LaBrie, James P. Mapes, Ralph L. McDade, Dominic Eisinger, Karri L. Ballard, Michael D. Spain
  • Publication number: 20110065136
    Abstract: Methods and devices for diagnosing, monitoring, or determining glomerulonephritis or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining glomerulonephritis or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.
    Type: Application
    Filed: August 6, 2010
    Publication date: March 17, 2011
    Applicant: Rules-Based Medicine, Inc.
    Inventors: Samuel T. Labrie, James P. Mapes, Ralph L. McDade, Dominic P. Eisinger, Karri L. Ballard, Michael D. Spain
  • Publication number: 20110065598
    Abstract: Methods and devices for diagnosing, monitoring, or determining diabetic nephropathy or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining diabetic nephropathy or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.
    Type: Application
    Filed: August 6, 2010
    Publication date: March 17, 2011
    Applicant: Rules-Based Medicine, Inc.
    Inventors: Samuel T. Labrie, James P. Mapes, Ralph L. McDade, Dominic Eisinger, Karri L. Ballard
  • Publication number: 20110065608
    Abstract: Devices for diagnosing, monitoring, or determining a renal disorder in a mammal are described. In particular, devices for diagnosing, monitoring, or determining a renal disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.
    Type: Application
    Filed: August 6, 2010
    Publication date: March 17, 2011
    Applicant: Rules-Based Medicine, Inc.
    Inventors: Samuel T. LaBrie, James P. Mapes, Ralph L. McDade, Dominic P. Eisinger, Karri L. Ballard, Michael D. Spain
  • Publication number: 20100197510
    Abstract: Methods are provided for screening for the necessity for further diagnosis of one or more diseases or conditions in a subject, which methods are based on the discovery that abnormal levels of selected analytes in a sample fluid from a subject can be correlated with specific diseases or conditions. Further provided are criteria, and methods for the determine thereof, for selected analytes with respect to selected diseases or conditions. Thus, a variety of diseases or conditions can be screened in a rapid, cost-effective composite assay. The methods are useful for screening of newborn humans for a variety of diseases and conditions, whereby additional diagnostic procedures need only be conducted for those diseases or conditions indicated by the methods of the invention.
    Type: Application
    Filed: March 7, 2008
    Publication date: August 5, 2010
    Inventors: Michael Spain, Craig Benson, James P. Mapes, Ralph L. McDade
  • Publication number: 20100068729
    Abstract: Provided are methods for the detection and diagnosis of a predisposition for developing diabetes. The methods are based on the discovery that abnormal levels of the selected analyte in biological samples, typically blood samples, of patients who are at risk are supportive of a diagnosis of a predisposition for developing diabetes. At least one new biomarker for a predisposition for diabetes is thus disclosed, IGF-1. Other important biomarkers for diabetes are described, including but not limited to ZAG, clusterin, corticosteroid-binding globulin, lumican, and serotransferrin. Kits containing reagents to assist in the analysis of biological samples are also described.
    Type: Application
    Filed: September 9, 2009
    Publication date: March 18, 2010
    Inventors: Samuel T. LABRIE, Michael D. Spain, James P. Mapes, Ralph L. McDade, Kenneth A. Pass
  • Publication number: 20080255766
    Abstract: Provided are methods for the detection and diagnosis of sickle cell. The methods are based on the discovery that abnormal levels of selected analytes in sample fluid, typically blood samples, of patients who are at risk are supportive of a diagnosis of sickle cell. At least two new biomarkers for sickle cell are thus disclosed, Eotaxin and Monocyte Chemotactic Protein-1. Altogether the concentrations of eleven analytes provide a sensitive and selective picture of the patient's condition, namely, whether the patient is suffering from sickle cell. Other important biomarkers for sickle cell are described, including but not limited to IL-12p40, SHBG, MMP-9, Adiponectin, Haptoglobin, FGF basic, IgM, Growth Hormone, Factor VII. Kits containing reagents to assist in the analysis of fluid samples are also described.
    Type: Application
    Filed: February 7, 2008
    Publication date: October 16, 2008
    Inventors: Michael Spain, James P. Mapes, Ralph L. McDade, Kenneth Pass