Abstract: A method for treating mammalian articular cartilage disorders, more particularly osteoarthritis, and trauma-related cartilage injuries using insulin-like growth factor I (IGF-I) is provided. The method comprises increasing the amount of IGF-I at the diseased or injured articular site to a therapeutically effective level that is capable of maintenance and/or regeneration of cartilage, which is beneficial to the long-term treatment of osteoarthritis and trauma-related injuries to cartilage tissues. In one embodiment of the invention, single doses of at least 0.01 mg of pharmaceutically effective IGF-I are administered intermittently such that the duration of time off of therapy is greater than the time on therapy, more preferably with a frequency of administration of about once per week or less.

Abstract: A method for treating mammalian articular cartilage disorders, more particularly osteoarthritis, and trauma-related cartilage injuries using insulin-like growth factor I (IGF-I) is provided. The method comprises increasing the amount of IGF-I at the diseased or injured articular site to a therapeutically effective level that is capable of maintenance and/or regeneration of cartilage, which is beneficial to the long-term treatment of osteoarthritis and trauma-related injuries to cartilage tissues. In one embodiment of the invention, single doses of at least 0.01 mg of pharmaceutically effective IGF-I are administered intermittently such that the duration of time off of therapy is greater than the time on therapy, more preferably with a frequency of administration of about once per week or less.

Abstract: A rack assembly comprising mounting means for containers, e.g., test tubes, a lid spaced from said mounting means which cooperates with orifices in the containers, a flexible sealing sheet for sealing the orifices interposed between the lid and mounting means, and means for spacing the lid from the mounting means and for gripping the sealing sheet. Containers are inserted in the mounting means. The sheet is then placed over the containers, and the lid in turn placed over the sheet so that the sheet seals the container orifices as the containers are maintained in substantially fixed position by the mounting means. By agitating the rack assembly the containers held therein are also shaken. The rack assembly is easily re-used by stripping off and discarding the sealing sheet.