Patents by Inventor Ralph New Harris

Ralph New Harris has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tetralin and indane derivatives and uses thereof
    Publication number: 20080293751
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, p, q, Ar, R1 and R2 are as defined herein. Also provided are methods for preparing, compositions comprising, and methods for using compounds of formula I.
    Type: Application
    Filed: November 15, 2007
    Publication date: November 27, 2008
    Inventors: Robert Greenhouse, Ralph New Harris, III, Saul Jaime-Figueroa, James M. Kress, David Bruce Repke, Russell Stephen Stabler
  • Heterocyclylakylamines as muscarinic receptor antagonists
    Patent number: 7361648
    Abstract: This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I: wherein X, Y, and Z are O, S or NR5, and the other substituents are as defined in the specification; and prodrugs, individual isomers, racemic or non-racemic mixtures of isomers, and pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.
    Type: Grant
    Filed: August 22, 2006
    Date of Patent: April 22, 2008
    Assignee: Roche Palo Alto LLC
    Inventors: Charles Alois Dvorak, Lawrence Emerson Fisher, Keena Lynn Green, Ralph New Harris, III, Hans Maag, Anthony Prince, David Bruce Repke, Russell Stephen Stabler
  • Arylsulfonamidyl tetralin derivatives and uses thereof
    Publication number: 20080015208
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein Ar, X, m, R1, R2 are as defined herein. Also provided are methods for preparing, compositions comprising, and methods for using compounds of formula I for treatment of 5-HT6-mediated diseases.
    Type: Application
    Filed: June 20, 2007
    Publication date: January 17, 2008
    Inventors: Ralph New Harris, James Kress, David Repke, Russell Stabler
  • Tetralin and indane derivatives and uses thereof
    Patent number: 7312359
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, p, q, Ar, R1 and R2 are as defined herein. Also provided are methods for preparing, compositions comprising, and methods for using compounds of formula I.
    Type: Grant
    Filed: December 21, 2005
    Date of Patent: December 25, 2007
    Assignee: Roche Palo Alto LLC
    Inventors: Robert Greenhouse, Ralph New Harris, III, Saul Jaime-Figueroa, James M. Kress, David Bruce Repke, Russell Stephen Stabler
  • Aryloxy quinolines and uses thereof
    Patent number: 7307089
    Abstract: Compounds of Formula 1 and pharmaceutically acceptable salts thereof, wherein m, Ar, R1, R2, and R3 are as defined herein. The invention also provides methods for preparing, coompositions comprising, and methods for using compounds of Formula 1 for treatment of central nervous system disorders.
    Type: Grant
    Filed: July 25, 2006
    Date of Patent: December 11, 2007
    Assignee: Roche Palo Alto LLC
    Inventors: Ralph New Harris, III, James M. Kress, David Bruce Repke, Russell Stephen Stabler
  • Dibenzoxazepinone derivatives and uses thereof
    Patent number: 7229984
    Abstract: Compounds of the Formula I: wherein m, n, k, A, X, Y, Z, Ar, R1, R2, R3, and R4 are as defined herein. The compounds are useful as 5-HT6 receptor antagonists. Also provided are compositions comprising, methods of using, and methods of making the subject compounds.
    Type: Grant
    Filed: December 9, 2005
    Date of Patent: June 12, 2007
    Assignee: Roche Palo Alto LLC
    Inventors: Ralph New Harris, III, James M. Kress, David Bruce Repke, Russell Stephen Stabler
  • Heterocyclylalkylamines as muscarinic receptor antagonists
    Patent number: 7094778
    Abstract: This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I: wherein X, Y, and Z are O, S or NR5, and the other substituents are as defined in the specification; and prodrugs, individual isomers, racemic or non-racemic mixtures of isomers, and pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.
    Type: Grant
    Filed: October 14, 2003
    Date of Patent: August 22, 2006
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Charles Alois Dvorak, Lawrence Emerson Fisher, Keena Lynn Green, Ralph New Harris, III, Hans Maag, Anthony Prince, David Bruce Repke, Russell Stephen Stabler
  • 4-piperazinyl benzenesulfonyl indoles and uses thereof
    Patent number: 7022708
    Abstract: This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula I: wherein R1, R2, R3, R4, and R5 are as defined herein; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.
    Type: Grant
    Filed: October 16, 2003
    Date of Patent: April 4, 2006
    Assignee: Roche Palo Alto LLC
    Inventors: Robin Douglas Clark, Ralph New Harris, III, David Bruce Repke
  • Quinolinone derivatives and uses thereof
    Patent number: 6943169
    Abstract: The invention provides compounds of the formula: and pharmaceutically acceptable salts or prodrugs thereof, wherein m, p, q, r, A, E, X, Y, R1, R4, R5, R6, R7, R8, R9 and are as defined herein. The invention also provides methods for preparing, compositions comprising, and methods for using compounds of formula I.
    Type: Grant
    Filed: March 10, 2004
    Date of Patent: September 13, 2005
    Assignee: Roche Palo Alto LLC
    Inventors: David Bruce Repke, Russell Stephen Stabler, Ralph New Harris, III
  • New indole derivatives with 5-HT6 receptor affinity
    Publication number: 20040248902
    Abstract: This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula I: 1
    Type: Application
    Filed: June 25, 2004
    Publication date: December 9, 2004
    Inventors: Colin Charles Beard, Robin Douglas Clark, Lawrence Emerson Fisher, Ralph New Harris, David Bruce Repke
  • Quinolinone derivaties and uses thereof
    Publication number: 20040186092
    Abstract: The invention provides compounds of the formula: 1
    Type: Application
    Filed: March 10, 2004
    Publication date: September 23, 2004
    Applicant: Roche Palo Alto LLC
    Inventors: David Bruce Repke, Russell Stephen Stabler, Ralph New Harris
  • 4-piperazinylindole derivatives with 5-HT6 receptor affinity
    Patent number: 6790848
    Abstract: This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula I: wherein R3 is SO2—Ar, Ar is aryl or heteroaryl; and R1, R2, R4 and R5 are as defined herein; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.
    Type: Grant
    Filed: June 14, 2002
    Date of Patent: September 14, 2004
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Andrew John Briggs, Robin Douglas Clark, Ralph New Harris, III, David Bruce Repke, Douglas Leslie Wren
  • Indole derivatives with 5HT6 receptor affinity
    Patent number: 6787535
    Abstract: This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula I: wherein one of R5, R6 or R7 is a group of general Formula B, wherein W is a —CH— group or a nitrogen atom, and the other substituents are as defined herein; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.
    Type: Grant
    Filed: June 6, 2002
    Date of Patent: September 7, 2004
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Colin Charles Beard, Robin Douglas Clark, Lawrence Emerson Fisher, Ralph New Harris, III, David Bruce Repke, David George Putman
  • 4-Piperazinyl benzenesulfonyl indoles and uses thereof
    Publication number: 20040087593
    Abstract: This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula I: 1
    Type: Application
    Filed: October 16, 2003
    Publication date: May 6, 2004
    Inventors: Robin Douglas Clark, Ralph New Harris, David Bruce Repke
  • Heterocyclylalkylamines as muscarinic receptor antagonists
    Publication number: 20040087581
    Abstract: This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I: 1
    Type: Application
    Filed: October 14, 2003
    Publication date: May 6, 2004
    Inventors: Charles Alois Dvorak, Lawrence Emerson Fisher, Keena Lynn Green, Ralph New Harris, Hans Maag, Anthony Prince, David Bruce Repke, Russell Stephen Stabler
  • Heterocyclylalkylamines as muscarinic receptor antagonists
    Patent number: 6667301
    Abstract: This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I: wherein X, Y, and Z are O, S or NR5, and the other substituents are as defined in the specification; and prodrugs, individual isomers, racemic or non-racemic mixtures of isomers, and pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.
    Type: Grant
    Filed: May 22, 2001
    Date of Patent: December 23, 2003
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Charles Alois Dvorak, Lawrence Emerson Fisher, Keena Lynn Green, Ralph New Harris, III, Hans Maag, Anthony Prince, David Bruce Repke, Russell Stephen Stabler
  • New indole derivatives with 5HT6 receptor affinity
    Publication number: 20030073700
    Abstract: This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula I: 1
    Type: Application
    Filed: June 6, 2002
    Publication date: April 17, 2003
    Inventors: Colin Charles Beard, Robin Douglas Clark, Lawrence Emerson Fisher, Ralph New Harris, David Bruce Repke
  • 4-piperazinylindole derivatives with 5-HT6 receptor affinity
    Publication number: 20030045527
    Abstract: This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula I: 1
    Type: Application
    Filed: June 14, 2002
    Publication date: March 6, 2003
    Inventors: Andrew John Briggs, Robin Douglas Clark, Ralph New Harris, David Bruce Repke, Douglas Leslie Wren
  • Heterocyclylalkylamines as muscarinic receptor antagonists
    Publication number: 20020004501
    Abstract: This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I: 1
    Type: Application
    Filed: May 22, 2001
    Publication date: January 10, 2002
    Inventors: Charles Alois Dvorak, Lawrence Emerson Fisher, Keena Lynn Green, Ralph New Harris, Hans Maag, Anthony Prince, David Bruce Repke, Russell Stephen Stabler
  • 2-arylethyl-(piperidin-4-ylmethyl)amine derivatives
    Patent number: 6319920
    Abstract: This invention relates to muscarinic receptor antagonist compounds selected from the group of compounds represented by Formula I: wherein the substituents are as defined in the specification; and their pharmaceutically acceptable salts, individual isomers or a racemic or non-racemic mixture; pharmaceutical compositions containing them; and methods for their use as therapeutic agents.
    Type: Grant
    Filed: February 1, 1999
    Date of Patent: November 20, 2001
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Joan Marie Caroon, Robin Douglas Clark, Michael Patrick Dillon, Ralph New Harris, III, Sharathchandra Surendra Hegde, Clara Jeou Jen Lin, Hans Maag, David Bruce Repke