Abstract: The present invention provides nucleic acid molecules comprising a MeCP2 expression cassette, the expression cassette comprising, in operable linkage from 5? to 3?: a 5? transcriptional control region comprising a promoter capable of driving transcription in neural cells; an open reading frame encoding a MeCP2 protein; translation control signals; a 3? untranslated region (3?UTR) comprising one or more of: (i) a binding site for mir-22; (ii) a binding site for mir-19; (iii) a binding site for miR-132; (iv) a binding site for miR124; and (v) an AU-rich element; and transcriptional termination signals; wherein the MeCP2 expression cassette is not more than about 5 kb in length. The invention further provides viral vectors, especially vectors derived from adeno-associated virus (AAV), for use in therapeutic delivery of such expression cassettes.

Abstract: A drive train for a wind-up injection device is described. The drive train includes a torsional energy storage adapted to be loaded or unloaded by a rotatable element, a rotatable user handle, a rotationally driveable expelling mechanism adapted to expel the liquid drug, and a clutch element coupled with the torsional energy storage via the rotatable element and including a ratchet for maintaining the rotatable element at one of a number of discrete angular positions against the torque of the torsional energy storage. The clutch element is adapted to transmit the torque from the user handle to the torsional energy storage, or alternatively from the torsional energy storage to the expelling mechanism. The ratchet is switchable from one position to an adjacent position by a torque transmitted from the user handle to the torsional energy storage. The drive train is adapted to dampen torque peaks visco-elastically and/or visco-frictionally.

Abstract: A button for a drug delivery device with a reduced operating loudness includes a plate-like button body forming a touch surface, wherein the plate-like button body is coupled by an axial supporting member to a noise-generating interface of the drug delivery device and movable into a longitudinal direction of the drug delivery device, wherein the plate-like button body includes a material composite with at least one first component consisting of a first material and at least one second component consisting of a second material different from the first material, wherein the at least one first component and the at least one second component are coupled via at least one coupling plane that is at least sectionwise slanted or perpendicular to the longitudinal direction. Further, the disclosure describes a button assembly for a drug delivery device which is shock resistant.

Abstract: Methods and systems are provided for manufacturing a hydraulic engine mount. During assembly, one or more gel caps may be inserted into a chamber of the engine mount, the chamber is then filled with a fluid and sealed to allow the gel caps to dissolve. Upon dissolving, the gel caps may release air bubbles to reduce pressure differentials across the engine mount to reduce occurrence of cavitation and NVH issues.

Abstract: Methods and systems are provided for manufacturing a hydraulic engine mount. During assembly, one or more gel caps may be inserted into a chamber of the engine mount, the chamber is then filled with a fluid and sealed to allow the gel caps to dissolve. Upon dissolving, the gel caps may release air bubbles to reduce pressure differentials across the engine mount to reduce occurrence of cavitation and NVH issues.

Abstract: Novel structural materials composed of industrial hemp fiber with recycled high density polyethylene (HDPE) as well as methods for the production of the same are disclosed. The material's mechanical strength outperforms that of conventional lumber and could compete with glass fiber reinforced composites, particularly in tensile strength. In addition, this material offers many other significant advantages including insect free, high moisture resistance, no harmful chemical treatments, and no rapid corrosion in water environments.

Abstract: In one embodiment, a pallet comprises a top deck comprising a substrate having a first surface and a second surface, wherein the substrate comprises a first plastic material; and a layer disposed on the second surface of the substrate, wherein the layer comprises a composition comprising reinforcing fibers, polyimide fibers, and polymeric binder fibers, wherein the polymeric binder fibers have a melting point that is lower than the polyimide fibers; a bottom deck; and supporting columns disposed between the second surface and the bottom deck.

Abstract: Novel structural materials composed of industrial hemp fiber with recycled high density polyethylene (HDPE) as well as methods for the production of the same are disclosed. The material's mechanical strength outperforms that of conventional lumber and could compete with glass fiber reinforced composites, particularly in tensile strength. In addition, this material offers many other significant advantages including insect free, high moisture resistance, no harmful chemical treatments, and no rapid corrosion in water environments.

Abstract: A resorbable screw fastener and a method of firing with an applicator capable of applying a surgical fastener to tissue in order to form tissue connection to secure objects to tissue, the fastener including a body portion having a helical thread, a head portion disposed at the proximal end of the body portion. The resorbable screw fastener is 100% resorbed in vivo during a period of time ranging from about 14 days to about one year after implantation.

Abstract: Novel structural materials composed of industrial hemp fiber with recycled high density polyethylene (HDPE) as well as methods for the production of the same are disclosed. The material's mechanical strength outperforms that of conventional lumber and could compete with glass fiber reinforced composites, particularly in tensile strength. In addition, this material offers many other significant advantages including insect free, high moisture resistance, no harmful chemical treatments, and no rapid corrosion in water environments.

Abstract: A resorbable screw fastener and a method of firing with an applicator capable of applying a surgical fastener to tissue in order to form tissue connection to secure objects to tissue, the fastener including a body portion having a helical thread, a head portion disposed at the proximal end of the body portion. The resorbable screw fastener is 100% resorbed in vivo during a period of time ranging from about 14 days to about one year after implantation.

Abstract: A resorbable screw fastener and a method of firing with an applicator capable of applying a surgical fastener to tissue in order to form tissue connection to secure objects to tissue, the fastener including a body portion having a helical thread, a head portion disposed at the proximal end of the body portion. The resorbable screw fastener is 100% resorbed in vivo during a period of time ranging from about 14 days to about one year after implantation.

Abstract: A scroll compressor may be provided with a check valve interposed between a balance chamber and a discharge chamber. The check valve may allow balance chamber pressure to remain low during start-up of the compressor. Low balance chamber pressure may allow an orbiting scroll to remain unclamped to a fixed scroll thereby reducing torque required to initiate rotation of the orbiting scroll. After steady-state operational speed is reached the check valve may close and the scrolls may be clamped together to produce a desired steady-state operating condition for the compressor.

Abstract: A resorbable screw fastener and a method of firing with an applicator capable of applying a surgical fastener to tissue in order to form tissue connection to secure objects to tissue, the fastener including a body portion having a helical thread, a head portion disposed at the proximal end of the body portion. The resorbable screw fastener is 100% resorbed in vivo during a period of time ranging from about 14 days to about one year after implantation.

Abstract: A scroll compressor may be provided with a check valve interposed between a balance chamber and a discharge chamber. The check valve may allow balance chamber pressure to remain low during start-up of the compressor. Low balance chamber pressure may allow an orbiting scroll to remain unclamped to a fixed scroll thereby reducing torque required to initiate rotation of the orbiting scroll. After steady-state operational speed is reached the check valve may close and the scrolls may be clamped together to produce a desired steady-state operating condition for the compressor.

Abstract: Methods and systems for securely connecting a client computer having a secure boot device to a remote server over a communications network are disclosed. One method includes booting a client computer from a trusted set of processing modules stored in the secure boot device, verifying the contents of the trusted set of processing modules prior to execution of these processing modules, and providing authentication information from data stored upon the secure boot device to an authentication server to establish a secure connection to the remote server. The method also includes establishing the secure connection with the remote server using encryption keys stored on the secure boot device, and transferring data between the client computer and the remote server over the secure connection to perform transactions initiated by a user of the client computer. In the disclosed method, the remote server utilizes encryption keys associated with a unique ID from the secure boot device.

Abstract: Novel structural materials composed of industrial hemp fiber with recycled high density polyethylene (HDPE) as well as methods for the production of the same are disclosed. The material's mechanical strength outperforms that of conventional lumber and could compete with glass fiber reinforced composites, particularly in tensile strength. In addition, this material offers many other significant advantages including insect free, high moisture resistance, no harmful chemical treatments, and no rapid corrosion in water environments.

Abstract: A resorbable screw fastener and a method of firing with an applicator capable of applying a surgical fastener to tissue in order to form tissue connection to secure objects to tissue, the fastener including a body portion having a helical thread, a head portion disposed at the proximal end of the body portion. The resorbable screw fastener is 100% resorbed in vivo during a period of time ranging from about 14 days to about one year after implantation.

Abstract: A resorbable screw fastener and a method of firing with an applicator capable of applying a surgical fastener to tissue in order to form tissue connection to secure objects to tissue, the fastener including a body portion having a helical thread, a head portion disposed at the proximal end of the body portion. The resorbable screw fastener is 100% resorbed in vivo during a period of time ranging from about 14 days to about one year after implantation.

Abstract: The present invention automates the process of receiving transportation documentation and producing advance loading manifests therefrom to optimize load planning and dynamic product shipment and delivery control. Methods provide for receipt of the transportation documentation, initial preparation, and transmission of the documentation from on board a vehicle or while the vehicle is in transit.