Patents by Inventor Ralph Sperling

Ralph Sperling has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10775374
    Abstract: The invention presents a stationary phase for detecting at least one specific analyte in a mixture. The stationary phase includes a solid phase divided into a plurality of zones for transporting liquid by capillary force. The solid phase includes at least one first zone suitable for receiving a liquid sample, a second zone on which a receptor is immobilized, wherein the receptor is suitable for binding to a ligand, and a third zone on which quantum dots are immobilized, function as FRET donors and are linked to at least one suitable FRET acceptor via at least one oligonucleotide linker. The stationary phase exhibits improved detection sensitivity and allows simultaneous and multiparametric detection of a wide variety of analytes. The invention proposes uses of the stationary phase and also presents a method for detecting at least one specific analyte in a mixture.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: September 15, 2020
    Assignee: Fraunhofer-Gesellschaft zur förderung der angewandten Forschung e.V.
    Inventors: Ralph Sperling, Ralf Himmelreich, Tobias Schunck, Raphael Thiermann
  • Publication number: 20070134679
    Abstract: The present invention discloses a method for separating nanoparticles with a controlled number of active groups is disclosed. First, a plurality of nanoparticles are provided, wherein the surface of the nanoparticle comprises a plurality of first active groups. Next, a plurality of functional ligands are provided, wherein the functional ligand comprises at least one second active group and at least one third active group. Then, a binding process is performed to bind the nanoparticle with the functional ligand, wherein the first active group connects with the second active group. After the binding process, a separation process is performed to isolate a plurality of nanoparticles with a controlled number of the third active groups. The controlled number is integers from 0 to 10.
    Type: Application
    Filed: December 14, 2005
    Publication date: June 14, 2007
    Inventors: Walter Chang, Jimmy Li, Ralph Sperling, Teresa Pellegrino, Wolfgang Parak