Patents by Inventor Ralph V. Clayman

Ralph V. Clayman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220304766
    Abstract: Provided herein are methods for treating nephrolithiasis and protecting the urothelium and inner lining of the kidney from thermal damage during lithotripsy by use of a thermosensitive bio-adhesive hydrogel. The described method dramatically improved the efficiency and effectiveness of stone clearance compared to conventional techniques while providing protection to the urothelium from potentially damaging temperature spikes.
    Type: Application
    Filed: March 24, 2022
    Publication date: September 29, 2022
    Applicants: UROGEN PHARMA LTD., The Regents of the University of California
    Inventors: Ralph V. CLAYMAN, Pengbo Jiang, Mark Schoenberg, Omer Tsipori
  • Publication number: 20220265350
    Abstract: The present technology relates to ureteroscopy, laser ablation of ureteral and renal stone, capture and removal of stone fragments. In one embodiment, the device includes an optical instrument operably connected to a large vacuum channel that is about 1.5 mm to about 8.0 mm in width. In another embodiment, the device includes two single-time use disposable or potentially reusable units, such as a large vacuum endoscope removal tip and a wireless and modular battery-powered handpiece.
    Type: Application
    Filed: May 6, 2022
    Publication date: August 25, 2022
    Inventors: Ralph V. Clayman, Kamaljot S. Kaler, Andrew Emon Heidari, Roshan M. Patel, Jamie Landman, Pengbo Jiang
  • Publication number: 20220126066
    Abstract: Various embodiments herein comprise a handheld load sensing device. In one embodiment, the device comprises a force sensor (e.g., a mechanical spring or an electromechanical load cell) adapted to receive a force, an input/output interface, and an adjustable attachment mechanism adapted to reversibly attach a surgical device. In another embodiment, the force sensor detects the amount of force applied during the deployment of the surgical device in a patient and outputs a force value representative thereof via the input/output interface. Also provided herein are methods of making and using load sensing devices.
    Type: Application
    Filed: January 7, 2022
    Publication date: April 28, 2022
    Inventors: Ralph V. Clayman, Kamaljot S. Kaler, Jamie Landman, Michael John Klopfer, Guann-Pyng Li
  • Publication number: 20190357762
    Abstract: The present technology relates to ureteroscopy, laser ablation of ureteral and renal stone, capture and removal of stone fragments. In one embodiment, the device includes an optical instrument operably connected to a large vacuum channel between 1.5 mm and 8.0 mm in width. In another embodiment, the device includes two single-time use disposable or potentially reusable units, such as a large vacuum endoscope removal tip and wireless and modular battery powered hand piece.
    Type: Application
    Filed: May 23, 2019
    Publication date: November 28, 2019
    Inventors: Ralph V. Clayman, Kamaljot S. Kaler, Andrew E. Heidari
  • Publication number: 20190274698
    Abstract: Provided herein are devices related to the removal of uroliths, including kidney, ureteral and/or bladder stones. In one embodiment, the device comprises a mesh or sponge that is removably connected to a catheter, adapted for the removal of urolith fragments of the size 2 mm or less. In one embodiment, the device includes a catheter that is either solid or hollow, the latter for the irrigation of various types of fluid (either standard irrigation fluid (e.g. saline or water) or a material (e.g. blood, fibrin glue, etc.) that would form a clot like substance within the interstices of the device thereby increasing its ability to entrap fragments within the interstices of the basket or nearby.
    Type: Application
    Filed: January 21, 2019
    Publication date: September 12, 2019
    Applicant: The Regents of the University of California
    Inventors: Kamaijot Kaler, Daniel Meller, Roshan M. Patel, Ralph V. Clayman
  • Publication number: 20190076209
    Abstract: The invention relates to medical devices and methods of use thereof, such as for example, ureteroscopy. In one embodiment, the device is a safety ureteral access sheath and interventional catheter insertion with a force meter and a force disengagement mechanism. In another embodiment, the invention provides a method of examination or treatment for a condition in a subject, comprising providing a device comprising a ureteral access sheath (UAS) operably linked to a force meter and a force disengagement mechanism, and using the device to examine or treat the subject.
    Type: Application
    Filed: September 11, 2018
    Publication date: March 14, 2019
    Applicant: The Regents of The University of California
    Inventors: Ralph V. Clayman, Kam Kaler, Michael Klopfer
  • Publication number: 20180311468
    Abstract: Provided herein is a load sensing device. In one embodiment, the device comprises a load cell adapted to receive a force, an input/output interface, and an adjustable attachment mechanism adapted to reversibly attach a surgical device. In another embodiment, the load cell detects the amount of force applied during the deployment of the surgical device in a patient and outputs a force value representative thereof via the input/output interface. Also provided herein are methods of making and using load sensing devices.
    Type: Application
    Filed: April 26, 2018
    Publication date: November 1, 2018
    Inventors: Ralph V. Clayman, Kamaljot S. Kaler, Jaime Landman, Michael J. Klopfer, Guann-Pyng Li
  • Patent number: 9155859
    Abstract: A ureteral access sheath adapted for insertion into a urethra includes an elongate tube extending between a proximal end and a distal end. A handle assembly is disposed at the proximal end and includes enlarged portions which inhibit migration of the sheath into the urethra. The enlarged portions are shaped like the bell of a horn with a concave, distally-facing outer surface and a convex, proximally-facing inner surface. The inner surface functions as a funnel while the outer surface is sized and configured to receive adjacent fingers of a user's hand held in its natural position. In an associated method, this shape of the handle assembly facilitates maintaining the sheath in a stationary position during insertion and removal of instrumentation. The handle assembly can be movable on the tube to facilitate variation of the sheath length.
    Type: Grant
    Filed: September 11, 2012
    Date of Patent: October 13, 2015
    Assignee: Applied Medical Resources Corporation
    Inventors: Gary R. Dulak, Ralph V. Clayman
  • Publication number: 20130006058
    Abstract: A ureteral access sheath adapted for insertion into a urethra includes an elongate tube extending between a proximal end and a distal end. A handle assembly is disposed at the proximal end and includes enlarged portions which inhibit migration of the sheath into the urethra. The enlarged portions are shaped like the bell of a horn with a concave, distally-facing outer surface and a convex, proximally-facing inner surface. The inner surface functions as a funnel while the outer surface is sized and configured to receive adjacent fingers of a user's hand held in its natural position. In an associated method, this shape of the handle assembly facilitates maintaining the sheath in a stationary position during insertion and removal of instrumentation. The handle assembly can be movable on the tube to facilitate variation of the sheath length.
    Type: Application
    Filed: September 11, 2012
    Publication date: January 3, 2013
    Applicant: Applied Medical Resources Corporation
    Inventors: Gary R. Dulak, Ralph V. Clayman
  • Patent number: 8308710
    Abstract: A high-flow low-pressure irrigation system for directing a fluid to and recovering the fluid from an area within a body, the irrigation system comprising a sheath defining a sheath lumen and a flexible catheter disposed in and through the sheath lumen. The catheter defines a catheter lumen and comprises a plurality of apertures at a distal portion that curls in a pigtail configuration. The fluid is directed and outputted to the body area through the catheter lumen and the apertures, and the outputted fluid is recovered and returned through the sheath lumen.
    Type: Grant
    Filed: August 29, 2002
    Date of Patent: November 13, 2012
    Assignee: Applied Medical Resources Corporation
    Inventors: Jaime Landman, Ralph V. Clayman, Richard C Ewers
  • Patent number: 8282622
    Abstract: A ureteral access sheath adapted for insertion into a urethra includes an elongate tube extending between a proximal end and a distal end. A handle assembly is disposed at the proximal end and includes enlarged portions which inhibit migration of the sheath into the urethra. The enlarged portions are shaped like the bell of a horn with a concave, distally-facing outer surface and a convex, proximally-facing inner surface. The inner surface functions as a funnel while the outer surface is sized and configured to receive adjacent fingers of a user's hand held in its natural position. In an associated method, this shape of the handle assembly facilitates maintaining the sheath in a stationary position during insertion and removal of instrumentation. The handle assembly can be movable on the tube to facilitate variation of the sheath link in situ.
    Type: Grant
    Filed: January 9, 2007
    Date of Patent: October 9, 2012
    Assignee: Applied Medical Resources Corporation
    Inventors: Gary R. Dulak, Ralph V. Clayman
  • Patent number: 7316677
    Abstract: A ureteral access sheath adapted for insertion into a urethra includes an elongate tube extending between a proximal end and a distal end. A handle assembly is disposed at the proximal end and includes enlarged portions which inhibit migration of the sheath into the urethra. The enlarged portions are shaped like the bell of a horn with a concave, distally-facing outer surface and a convex, proximally-facing inner surface. The inner surface functions as a funnel while the outer surface is sized and configured to receive adjacent fingers of a user's hand held in its natural position. In an associated method, this shape of the handle assembly facilitates maintaining the sheath in a stationary position during insertion and removal of instrumentation. The handle assembly can be movable on the tube to facilitate variation of the sheath link in situ.
    Type: Grant
    Filed: July 17, 2002
    Date of Patent: January 8, 2008
    Assignee: Applied Medical Resources Corporation
    Inventors: Gary R. Dulak, Ralph V. Clayman
  • Patent number: 7135015
    Abstract: A ureteral access sheath adapted for insertion into a urethra includes an elongate tube extending between a proximal end and a distal end. A handle assembly is disposed at the proximal end and includes enlarged portions which inhibit migration of the sheath into the urethra. The enlarged portions are shaped like the bell of a horn with a concave, distally-facing outer surface and a convex, proximally-facing inner surface. The inner surface functions as a funnel while the outer surface is sized and configured to receive adjacent fingers of a user's hand held in its natural position. In an associated method, this shape of the handle assembly facilitates maintaining the sheath in a stationary position during insertion and removal of instrumentation. The handle assembly can be movable on the tube to facilitate variation of the sheath link in situ.
    Type: Grant
    Filed: June 13, 2001
    Date of Patent: November 14, 2006
    Assignee: Applied Medical Resources Corporation
    Inventors: Gary R. Dulak, Ralph V. Clayman
  • Patent number: 6945950
    Abstract: A ureteral stent for assisting movement of urine along a patient's ureter and into the patient's bladder. The stent includes an elongated tubular segment extending toward the bladder from a kidney end region for placement in the renal cavity to a bladder end region. A central lumen connects at least one opening at the first end region to at least one opening in the bladder end region. Thin flexible tail(s) are attached to the bladder end region of the tubular segment at a point outside the bladder so as to receive urine from the opening in the bladder end region and to transport urine from there across the ureter/bladder junction and into the bladder. The tails include an elongated external urine-transport surface configured to transport urine. The transporting surface(s) are configured to extend along at least part of the ureter, across the ureter/bladder junction, and into the bladder.
    Type: Grant
    Filed: September 12, 2003
    Date of Patent: September 20, 2005
    Assignee: Boston Scientific SciMed, Inc.
    Inventors: Ralph V. Clayman, Alyssa J. Dassa, Christopher Fishbein, Douglas E. Godshall, Willet F. Whitemore, III
  • Patent number: 6849069
    Abstract: A ureteral stent for assisting movement of urine along a patient's ureter and into the patient's bladder. The stent includes an elongated tubular segment extending toward the bladder from a kidney end region for placement in the renal cavity to a bladder end region. A central lumen connects at least one opening at the first end region to at least one opening in the bladder end region. Thin flexible tail(s) are attached to the bladder end region of the tubular segment at a point outside the bladder so as to receive urine from the opening in the bladder end region of the tubular segment and to transport urine from there across the ureter/bladder junction and into the bladder. The tails include an elongated external urine-transport surface sized and configured to transport urine along the ureter. The urine transporting surface(s) are sized and configured to extend along at least part of the ureter, across the ureter/bladder junction, and from there into the bladder.
    Type: Grant
    Filed: November 6, 1996
    Date of Patent: February 1, 2005
    Assignee: Boston Scientitfic Corporation
    Inventors: Ralph V. Clayman, Alyssa J. Dassa, Christopher Fishbein, Douglas E. Godshall, Willet F. Whitmore, III
  • Publication number: 20040199048
    Abstract: A medical device for viewing inside a body and for retrieving an object from a location within the body, the medical device comprising an endoscope having a tube defining a working channel and a basket engageable with the object. In one embodiment of the invention, the basket does not require a sheath and is disposed through the working channel such that the endoscope operates to contain or activate the sheathless basket. In another embodiment of the invention, a single push wire with a collar at its end is used in place of a sheath to control the opening and closing of the basket. In another embodiment of the invention, a tapered and funnel-shaped sheath surrounding the basket is used to contain or activate the basket. The invention minimizes the basket crossing profile so as to improve fluid flow in the working channel.
    Type: Application
    Filed: April 8, 2004
    Publication date: October 7, 2004
    Inventors: Ralph V Clayman, Nabil Hilal, Edward D Pingleton, Richard C Ewers
  • Publication number: 20040181175
    Abstract: A urological guidewire includes a core formed of a first metallic material and extending toward an end of the guidewire. A coil having a plurality of convolutions is disposed around the core at the end of the guidewire, the coil being formed of a second metallic material different than the first metallic material. A mechanical interlock is formed to inhibit separation of the different materials forming the coil and the core. The mechanical interlock may include an enlargement at the end of the core and a bonding material fixing the enlargement to the coil. The convolutions may include a penultimate convolution with a first radius of curvature and an ultimate convolution having a second, shorter radius of curvature to form a bridge. In this case, portions of the core can be bent back on themselves and directed over or around the bridge to form the mechanical interlock.
    Type: Application
    Filed: January 13, 2004
    Publication date: September 16, 2004
    Inventors: Ralph V. Clayman, Edward D. Pingleton, Frans Vandenbroek, Ghassan Sakakine
  • Patent number: 6773432
    Abstract: An electrosurgical instrument includes a handle with a hollow elongate configuration and an electrosurgical assembly having ends disposed within the hollow handle and forming a continuous loop moveable by operation of the handle between an enlarged state and a contracted state. An electrosurgical element included in the assembly has an outer surface and axis and a lumen extending along the axis. Transverse portions of the element define a plurality of slots extending transverse to the axis and providing fluid communication between the lumen and the outer surface of the element. The element includes an insulated backbone and a plurality of ribs disposed to extend in space relationship to each other transverse to the backbone. A method of manufacture includes the step of creating slots in the element to define the ribs in the backbone.
    Type: Grant
    Filed: April 5, 2002
    Date of Patent: August 10, 2004
    Assignee: Applied Medical Resources Corporation
    Inventors: Ralph V. Clayman, William C. Collyer, Jaime Landman
  • Publication number: 20040127820
    Abstract: A urological guidewire includes a core formed of a first metallic material and extending toward an end of the guidewire. A coil having a plurality of convolutions is disposed around the core at the end of the guidewire, the coil being formed of a second metallic material different than the first metallic material. A mechanical interlock is formed to inhibit separation of the different materials forming the coil and the core. The mechanical interlock may include an enlargement at the end of the core and a bonding material fixing the enlargement to the coil. The convolutions may include a penultimate convolution with a first radius of curvature and an ultimate convolution having a second, shorter radius of curvature to form a bridge. In this case, portions of the core can be bent back on themselves and directed over or around the bridge to form the mechanical interlock.
    Type: Application
    Filed: December 12, 2003
    Publication date: July 1, 2004
    Inventors: Ralph V. Clayman, Edward D. Fingleton, Frans Vandenbroek, Ghassan Sakakine
  • Publication number: 20040092857
    Abstract: A ureteral stent for assisting movement of urine along a patient's ureter and into the patient's bladder. The stent includes an elongated tubular segment extending toward the bladder from a kidney end region for placement in the renal cavity to a bladder end region. A central lumen connects at least one opening at the first end region to at least one opening in the bladder end region. Thin flexible tail(s) are attached to the bladder end region of the tubular segment at a point outside the bladder so as to receive urine from the opening in the bladder end region of the tubular segment and to transport urine from there across the ureter/bladder junction and into the bladder. The tails include an elongated external urine-transport surface sized and configured to transport urine along the ureter. The urine transporting surface(s) are sized and configured to extend along at least part of the ureter, across the ureter/bladder junction, and from there into the bladder.
    Type: Application
    Filed: September 12, 2003
    Publication date: May 13, 2004
    Inventors: Ralph V. Clayman, Alyssa J. Dassa, Christopher Fishbein, Douglas E. Godshall, Willett F. Whitmore