Patents by Inventor Ralph Weisheit

Ralph Weisheit has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for determining alkaline phosphatase and eliminating haemoglobin disturbances
    Patent number: 6720163
    Abstract: The invention concerns a method for the determination of alkaline phosphatase in a sample by optical measurement in which interference by free haemoglobin or blood substitutes is eliminated by means of certain wavelength combinations, a method for eliminating interference caused by free haemoglobin or blood substitutes in a determination of alkaline phosphatase and the use of certain wavelength combinations to eliminate interference by free haemoglobin or blood substitutes.
    Type: Grant
    Filed: April 6, 2001
    Date of Patent: April 13, 2004
    Assignee: Roche Diagnostics GmbH
    Inventors: Ralph Weisheit, Wolfgang Treiber
  • Method for determining alkaline phosphatase
    Patent number: 6713275
    Abstract: The invention concerns a method for the determination of alkaline phosphatase in a sample by optical measurement which is characterized in that a main measurement wavelength of 450±10 nm in combination with the rate blank procedure is used to eliminate haemoglobin interference, a method for eliminating interference by free haemoglobin or blood substitutes and the use of the combination of a main measurement wavelength with the rate blank procedure to eliminate interference by free haemoglobin or blood substitutes in the determination of alkaline phosphatase.
    Type: Grant
    Filed: April 6, 2001
    Date of Patent: March 30, 2004
    Assignee: Roche Diagnostics GmbH
    Inventors: Ralph Weisheit, Wolfgang Treiber
  • Method for the analysis of medical samples containing haemoglobin
    Patent number: 6207459
    Abstract: The invention concerns a method for the determination of an analyte in a sample containing free haemoglobin in which the determination is carried out by an optical measurement and the value measured for the analyte concentration is mathematically corrected. This method is in particular suitable for determining the parameters total protein, iron and albumin in a medical sample e.g. in a serum or plasma sample. The correction of the measured value for the analyte concentration is achieved by the steps (a) measuring the blank value of the sample to be analysed, (b) measuring the blank value of a haemoglobin-free reference sample, (c) measuring the uncorrected value for the analyte concentration and (d) correcting the value obtained in step (c) by correlation with the values obtained in step (a) and (b) in order to obtain the corrected value for the analyte concentration.
    Type: Grant
    Filed: November 20, 1998
    Date of Patent: March 27, 2001
    Assignee: Roche Diagnostics GmbH
    Inventors: Ralph Weisheit, Lieselotte Schellong
  • Method and reagent for the determination of iron
    Patent number: 5763281
    Abstract: In order to determine iron in serum by releasing the bound iron through addition of a protein denaturing agent, reduction of the released iron to Fe.sup.2+, addition of a color reagent solution and photometric measurement of the color complex that forms, a mixture of a denaturing agent containing urea or a urea derivative and a fatty alcohol polyglycol ether are added to the sample solution.
    Type: Grant
    Filed: July 11, 1996
    Date of Patent: June 9, 1998
    Assignee: Boehringer Mannheim GmbH
    Inventors: Ralph Weisheit, Renate Luz