Patents by Inventor Ralph Wilfred Paul

Ralph Wilfred Paul has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mini-E1A gene and gene products
    Patent number: 6683059
    Abstract: The present invention provides methods and compositions for the suppression of oncogenic transformation, tumorigenesis and metastasis. The present invention discloses functional domains of E1A responsible for the suppression of transformation, and provides mini-E1A constructs that can be used for tumor suppression. The invention also discloses methods for the novel use of mini-E1A in combination with chemotherapeutic drugs and/or tyrosine kinase inhibitors.
    Type: Grant
    Filed: November 21, 2000
    Date of Patent: January 27, 2004
    Assignee: Board of Regents, The University of Texas System
    Inventors: Mien-Chie Hung, Hua Chen, Dihua Yu, Ralph Wilfred Paul, Aaron Garth Loomis, Daniel Nathan Andrew LaFoc
  • Stable lipid-comprising durg delivery complexesand methods for their production
    Publication number: 20030212031
    Abstract: Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the prior art admixture method and upon purification, the complexes produced by the method of this invention are 50 to 500 fold more concentrated than the complexes formed by admixture. The method described herein provides for the large scale production of lipid-comprising drug delivery systems useful for gene therapy and other applications.
    Type: Application
    Filed: April 29, 2003
    Publication date: November 13, 2003
    Inventors: Leaf Huang, Xiang Gao, Frank L. Sorgi, Ralph Wilfred Paul, David L. Sloane, Aaron Garth Loomis
  • Stable lipid-comprising drug delivery complexes and methods for their production
    Patent number: 6008202
    Abstract: Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the prior art admixture method and upon purification, the complexes produced by the method of this invention are 50 to 500 fold more concentrated than the complexes formed by admixture. The method described herein provides for the large scale production of lipid-comprising drug delivery systems useful for gene therapy and other applications.
    Type: Grant
    Filed: September 29, 1997
    Date of Patent: December 28, 1999
    Assignees: University of Pittsburgh, Targeted Genetics Corporation
    Inventors: Leaf Huang, Xiang Gao, Frank L. Sorgi, Ralph Wilfred Paul, David L. Sloane, Aaron Garth Loomis