Abstract: There is disclosed a power conversion circuit comprising a transformer having a primary side driven by an input section and a secondary side connected to first and second self-driven synchronous rectifiers. A shutdown section includes a control section adapted to detect a predetermined condition and means for shorting a winding of the transformer upon detection of the predetermined condition.

Abstract: There is disclosed a power conversion circuit comprising a transformer having a primary side driven by an input section and a secondary side connected to first and second self-driven synchronous rectifiers. A shutdown section includes a control section adapted to detect a predetermined condition and means for shorting a winding of the transformer upon detection of the predetermined condition.

Abstract: There is disclosed a power conversion circuit including self synchronous rectifiers and a rapid shutdown section. When power is removed from the power conversion circuit, the rapid shutdown section prevents self oscillation of the self synchronous rectifiers. As a result, power is not drawn from the output and dissipated in the power conversion circuit.

Abstract: There is disclosed a power conversion circuit including self synchronous rectifiers and a rapid shutdown section. When power is removed from the power conversion circuit, the rapid shutdown section prevents self oscillation of the self synchronous rectifiers. As a result, power is not drawn from the output and dissipated in the power conversion circuit.

Abstract: The present invention provides methods and compositions for the integration of a nucleotide sequence of interest into the genome. Specifically, the methods of the present invention comprise contacting a lentiviral vector with the plasma membrane of an oocyte, early stage embryo, or blastula under conditions that permit the entry of the viral vector and the subsequent integration of the nucleotide sequence of interest into the genome. The methods further comprise culturing the oocyte or embryo contacted with the lentiviral vector under conditions that allow for the formation of a pre-implantation embryo. Subsequently, the pre-implantation embryo can be transferred into a recipient vertebrate where it is allowed to develop into at least one genetically modified animal. The methods and compositions of the invention thereby allow for the production of genetically modified animals, particularly, vertebrates, and particularly mammals.