Patents by Inventor Rama K. Mishra

Rama K. Mishra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CYTOCHROME P450 INHIBITORS AND USES THEREOF
    Publication number: 20180148438
    Abstract: The present invention provides compounds having the general structural formula (I) and pharmaceutically acceptable derivatives thereof, as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases involving fibrosis and proliferation, and where anti-fibrotic or anti-proliferative activity is beneficial.
    Type: Application
    Filed: November 29, 2016
    Publication date: May 31, 2018
    Applicant: Angion Biomedica Corp
    Inventors: Bijoy Panicker, Dong Sung Lim, Rama K. Mishra, Lambertus J.W.M. Oehlen, James G. Tarrant, Xiaokang Zhu, Dawoon Jung
  • ANTIFIBROTIC COMPOUNDS AND USES THEREOF
    Publication number: 20180008581
    Abstract: The present invention provides compounds having the general structural formula (I) and pharmaceutically acceptable derivatives thereof, as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases involving abnormal or excessive fibrosis.
    Type: Application
    Filed: March 19, 2017
    Publication date: January 11, 2018
    Applicant: ANGION BIOMEDICA CORP.
    Inventors: Bijoy PANICKER, Rama K. MISHRA, Dong Sung LIM, Lambertus J.W.M. OEHLEN, Dawoon JUNG
  • SUBSTITUTED HETEROCYCLES AS c-MYC TARGETING AGENTS
    Publication number: 20170253581
    Abstract: Disclosed are substituted heterocycles compounds including substituted pyrazoles, substituted pyrimidines, and substitute triazoles. The substituted heterocycles disclosed herein are shown to be useful in inhibiting c-MYC and may be utilized as therapeutics for treating cancer and cell proliferative disorders.
    Type: Application
    Filed: March 7, 2017
    Publication date: September 7, 2017
    Applicant: Northwestern University
    Inventors: Gary E. Schiltz, Rama K. Mishra, Huiying Han, Sarki A. Abdulkadir
  • SUBSTITUTED AROMATIC N-HETEROCYCLIC COMPOUNDS AS INHIBITORS OF MITOGEN-ACTIVATED PROTEIN KINASE INTERACTING KINASE 1 (MNK1) AND 2 (MNK2)
    Publication number: 20170121326
    Abstract: Disclosed are substituted aromatic N-heterocyclic compounds. The disclosed compounds typically exhibit kinase inhibition activity, for example, and inhibit Mnk1 kinase and/or Mnk2 kinase. The disclosed compounds may be used in pharmaceutical compositions and methods for treating diseases or disorders associated with Mnk1 kinase activity and/or Mnk2 kinase activity, such as cancers, diabetes, autism, and fragile X syndrome.
    Type: Application
    Filed: October 28, 2016
    Publication date: May 4, 2017
    Applicant: Northwestern University
    Inventors: Gary E. Schiltz, Rama K. Mishra, Leonidas C. Platanias, Javier Izquierdo-Ferrer
  • Antifibrotic compounds and uses thereof
    Patent number: 9597321
    Abstract: The present invention provides compounds having the general structural formula (I) and pharmaceutically acceptable derivatives thereof, as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases involving abnormal or excessive fibrosis.
    Type: Grant
    Filed: May 5, 2015
    Date of Patent: March 21, 2017
    Assignee: Angion Biomedica Corp.
    Inventors: Bijoy Panicker, Rama K. Mishra, Dong Sung Lim, Lambertus J. W. M. Oehlen, Dawoon Jung
  • RELAXIN-LIKE COMPOUNDS AND USES THEREOF
    Publication number: 20160152679
    Abstract: The present invention is directed to novel relaxin-like compounds having at least one intramolecular or intramolecular bridge that is a bioisosteric substitution of a cystine.
    Type: Application
    Filed: May 24, 2013
    Publication date: June 2, 2016
    Applicant: ANGION BIOMEDICA CORP.
    Inventors: Prakash Narayan, Rama K. Mishra, E. Siobhan McCormack, Victor M. Garsky, Itzhak D. Goldberg
  • RELAXIN-LIKE PEPTIDES AND USES THEREOF
    Publication number: 20160060322
    Abstract: The present invention is directed to novel peptides that exhibit relaxin activity, and uses thereof for treating diseases such as heart failure and liver, lung, cardiac or kidney fibrosis.
    Type: Application
    Filed: September 10, 2013
    Publication date: March 3, 2016
    Applicant: ANGION BIOMEDICA CORP.
    Inventors: Parkash Narayan, Itzhak D. Goldberg, Rama K. Mishra, E. Siobhan McCormack, Dawoon Jung
  • ANTIFIBROTIC COMPOUNDS AND USES THEREOF
    Publication number: 20150306078
    Abstract: The present invention provides compounds having the general structural formula (I) and pharmaceutically acceptable derivatives thereof, as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases involving abnormal or excessive fibrosis.
    Type: Application
    Filed: May 5, 2015
    Publication date: October 29, 2015
    Applicant: ANGION BIOMEDICA CORP.
    Inventors: Bijoy PANICKER, Rama K. MISHRA, Dong Sung LIM, Lambertus J.W.M. OEHLEN, Dawoon JUNG
  • CYTOCHROME P450 INHIBITORS AND USES THEREOF
    Publication number: 20150158853
    Abstract: The present invention provides compounds having the general structural formula (I) and pharmaceutically acceptable derivatives thereof, as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases involving fibrosis and proliferation, and where anti-fibrotic or anti-proliferative activity is beneficial.
    Type: Application
    Filed: September 23, 2014
    Publication date: June 11, 2015
    Applicant: ANGION BIOMEDICA CORP
    Inventors: Bijoy Panicker, Dong Sung Lim, Rama K. Mishra, Lambertus J.W.M. Oehlen, James G. Tarrant, Xiaokang Zhu, Dawoon Jung
  • Antifibrotic compounds and uses thereof
    Patent number: 9040555
    Abstract: The present invention provides compounds having the general structural formula (I), and pharmaceutically acceptable derivatives thereof, as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases involving abnormal or excessive fibrosis.
    Type: Grant
    Filed: January 26, 2013
    Date of Patent: May 26, 2015
    Assignee: Angion Biomedica Corp.
    Inventors: Bijoy Panicker, Rama K. Mishra, Dong Sung Lim, Lambertus J. W. M. Oehlen, Dawoon Jung
  • ANTIFIBROTIC COMPOUNDS AND USES THEREOF
    Publication number: 20140371234
    Abstract: The present invention provides compounds having the general structural formula (I), and pharmaceutically acceptable derivatives thereof, as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases involving abnormal or excessive fibrosis.
    Type: Application
    Filed: January 26, 2013
    Publication date: December 18, 2014
    Applicant: ANGION BIOMEDICA CORP.
    Inventors: Bijoy Panicker, Rama K. Mishra, Dong Sung Lim, Lambertus J.W.M. Oehlen, Dawoon Jung
  • Cytochrome P450 inhibitors and uses thereof
    Patent number: 8865752
    Abstract: The present invention provides compounds having the general structural formula (I) and pharmaceutically acceptable derivatives thereof, as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases involving fibrosis and proliferation, and where anti-fibrotic or anti-proliferative activity is beneficial.
    Type: Grant
    Filed: July 4, 2013
    Date of Patent: October 21, 2014
    Assignee: Angion Biomedica Corp.
    Inventors: Bijoy Panicker, Dong Sung Lim, Rama K. Mishra, Lambertus J. W. M. Oehlen, James G. Tarrant, Xiaokang Zhu, Dawoon Jung
  • CYTOCHROME P450 INHIBITORS AND USES THEREOF
    Publication number: 20140018401
    Abstract: The present invention provides compounds having the general structural formula (I) and pharmaceutically acceptable derivatives thereof, as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases involving fibrosis and proliferation, and where anti-fibrotic or anti-proliferative activity is beneficial.
    Type: Application
    Filed: July 4, 2013
    Publication date: January 16, 2014
    Applicant: ANGION BIOMEDICA CORP
    Inventors: Bijoy Panicker, Dong Sung Lim, Rama K. Mishra, Lambertus J.W.M. Oehlen, James G. Tarrant, Xiaokang Zhu, Dawoon Jung
  • Biaryl substituted heterocycle inhibitors of LTA4H for treating inflammation
    Patent number: 8598359
    Abstract: The present invention relates to a chemical genus of biaryl substituted heterocycle inhibitors of LTA4H (leukotriene A4 hydrolase) useful for the treatment and prevention and prophylaxis of inflammatory diseases and disorders.
    Type: Grant
    Filed: June 11, 2008
    Date of Patent: December 3, 2013
    Assignee: Decode Genetics EHF
    Inventors: Vincent Sandanayaka, Jasbir Singh, Mark Gurney, Bjorn Mamat, Peng Yu, Louis Bedell, Lei Zhao, Rama K. Mishra
  • Cytochrome P450 inhibitors and uses thereof
    Patent number: 8513291
    Abstract: The present invention provides compounds having the general structural formula (I) and pharmaceutically acceptable derivatives thereof, as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases involving fibrosis and proliferation, and where anti-fibrotic or anti-proliferative activity is beneficial.
    Type: Grant
    Filed: June 1, 2011
    Date of Patent: August 20, 2013
    Assignee: Angion Biomedica Corp.
    Inventors: Bijoy Panicker, Lambertus J. W. M. Oehlen, James G. Tarrant, Dong Sung Lim, Xiaokang Zhu, Dawoon Jung, Rama K. Mishra
  • CYTOCHROME P450 INHIBITORS AND USES THEREOF
    Publication number: 20130102643
    Abstract: The present invention provides compounds having the general structural formula (I) and pharmaceutically acceptable derivatives thereof, as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases involving fibrosis and proliferation, and where anti-fibrotic or anti-proliferative activity is beneficial.
    Type: Application
    Filed: June 1, 2011
    Publication date: April 25, 2013
    Inventors: Bijoy Panicker, Lambertus J.W.M. Oehlen, James G. Tarrant, Dong Sung Lim, Xiaokang Zhu, Dawoon Jung, Rama K. Mishra
  • SMALL MOLECULE MODULATORS OF CYTOKINE ACTIVITY
    Publication number: 20100137285
    Abstract: The present invention provides compounds having formula (I) or (II): and pharmaceutically acceptable derivatives thereof, wherein m, p, R1, R2, R3 and R4 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of diseases, disorders or conditions associated with HGF/SF or other cytokine activity.
    Type: Application
    Filed: November 30, 2009
    Publication date: June 3, 2010
    Applicant: ANGION BIOMEDICA CORP.
    Inventors: David E. Zembower, Jasbir Singh, Rama K. Mishra
  • Small molecule modulators of cytokine activity
    Patent number: 7648978
    Abstract: The present invention provides compounds having formula (I) or (II): and pharmaceutically acceptable derivatives thereof, wherein m, p, R1, R2, R3 and R4 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of diseases, disorders or conditions associated with HGF/SF or other cytokine activity.
    Type: Grant
    Filed: September 28, 2005
    Date of Patent: January 19, 2010
    Assignee: Angion Biomedica Corp.
    Inventors: David E. Zembower, Jasbir Singh, Rama K. Mishra
  • BIARYL SUBSTITUTED HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION
    Publication number: 20090163462
    Abstract: The present invention relates to a chemical genus of biaryl substituted heterocycle inhibitors of LTA4H (leukotriene A4 hydrolase) useful for the treatment and prevention and prophylaxis of inflammatory diseases and disorders.
    Type: Application
    Filed: June 11, 2008
    Publication date: June 25, 2009
    Applicant: deCODE genetics, ehf
    Inventors: Vincent SANDANAYAKA, Jasbir Singh, Mark Gurney, Bjorn Mamat, Peng Yu, Louis Bedell, Lei Zhao, Rama K. Mishra
  • Biaryl substituted heterocycle inhibitors of LTA4H for treating inflammation
    Patent number: 7402684
    Abstract: The present invention relates to a chemical genus of biaryl substituted heterocycle inhibitors of LTA4H (leukotriene A4 hydrolase) useful for the treatment and prevention and prophylaxis of inflammatory diseases and disorders.
    Type: Grant
    Filed: June 23, 2006
    Date of Patent: July 22, 2008
    Assignee: deCODE genectics ehf.
    Inventors: Vincent Sandanayaka, Jasbir Singh, Mark Gurney, Bjorn Mamat, Peng Yu, Louis Bedell, Lei Zhao, Rama K. Mishra