Patents by Inventor Ramamoorthy Belagaje

Ramamoorthy Belagaje has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for using a novel transcriptional- and translational-activating sequence in streptomyces
    Patent number: 4752577
    Abstract: The present invention is a method for expressing functional polypeptides in Streptomyces using a recombinant DNA expression vector comprising a novel transcriptional- and translational- activating sequence. The novel activating sequence can be synthesized by conventional methods and used in Streptomyces expression vectors. One such vector, plasmid pFJ350, expresses and confers hygromycin resistance in Streptomyces host cells.
    Type: Grant
    Filed: September 13, 1984
    Date of Patent: June 21, 1988
    Assignee: Eli Lilly and Company
    Inventors: Ramamoorthy Belagaje, Jeffrey T. Fayerman, Mark A. Richardson
  • Derivative of the tryptophan operon for expression of fused gene products
    Patent number: 4738921
    Abstract: The present invention comprises improved derivatives of the tryptophan operon useful for expressing fused gene products in E. coli and relate organism. Two of the improved derivatives disclosed are encoded on 0.43 and 0.55 kb EcoRI restriction fragments from plasmids pCZ20 and pLEBGH2 (in strains NRRL B-15881 and NRRL B-15882), respectively. The modified derivatives have been placed on recombinant DNA cloning and expression vectors. A variety of expression vectors have been constructed that drive expression of fused gene products. Two novel gene sequences, encoding insulin-like growth factors I and II, have been expressed with the modified tryptophan operon system.
    Type: Grant
    Filed: September 27, 1984
    Date of Patent: April 19, 1988
    Assignee: Eli Lilly and Company
    Inventors: Ramamoorthy Belagaje, Janet K. Epp, JoAnn Hoskins, Hansen M. Hsiung, George L. Long, Brigitte E. Schoner
  • Transcription terminators
    Patent number: 4710464
    Abstract: The present transcription terminators are DNA sequences characterized by their ability to terminate the transcription of DNA sequences. The present sequences are portable, have a variety of restriction endonuclease sites and are useful in controlling the expression in hosts of DNA sequences coding for prokaryotic, eukaryotic and viral proteins and polypeptides.
    Type: Grant
    Filed: September 27, 1984
    Date of Patent: December 1, 1987
    Assignee: Eli Lilly and Company
    Inventors: Ramamoorthy Belagaje, Stuart A. Kuhstoss, R. Nagaraja Rao