Patents by Inventor Rama Mukherjee
Rama Mukherjee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8927023Abstract: The invention relates to a biocompatible, non-biodegradable, and non-toxic polymer of formula (I), comprising of three monomeric units, selected from 1-Vinylpyrrolidne (VP), N-Isopropylactylamide (NIPAM), and ester of Maleic anhydride and Polyethylene glycol (MPEG), cross-linked with a bi-functional vinyl derivative, of high purity and substantially free of respective toxic monomeric contaminants, and a process for preparation thereof. The invention further relates to nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds comprising the polymer of the invention, which are safe, less-toxic and convenient for bedside administration to patients in need thereof. Furthermore, the invention relates to a highly selective method for preparation of nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds.Type: GrantFiled: October 2, 2012Date of Patent: January 6, 2015Assignee: Fresenius Kabi Oncology LimitedInventors: Anand C. Burman, Rama Mukherjee, Dhiraj Khattar, Sanjoy Mullick, Manu Jaggi, Manoj Kumar Singh, Mukesh Kumar, Deepak Prusthy, Pawan Kumar Gupta, Rajendran Praveen, Shobhit Singh
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Publication number: 20130274211Abstract: The invention relates to a biocompatible, non-biodegradable, and non-toxic polymer of formula (I), comprising of three monomeric units, selected from 1-Vinylpyrrolidne (VP), N-Isopropylactylamide (NIPAM), and ester of Maleic anhydride and Polyethylene glycol (MPEG), cross-linked with a bi-functional vinyl derivative, of high purity and substantially free of respective toxic monomeric contaminants, and a process for preparation thereof. The invention further relates to nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds comprising the polymer of the invention, which are safe, less-toxic and convenient for bedside administration to patients in need thereof. Furthermore, the invention relates to a highly selective method for preparation of nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds.Type: ApplicationFiled: October 2, 2012Publication date: October 17, 2013Applicant: Fresenius Kabi Oncology LimitedInventors: Anand C. Burman, Rama Mukherjee, Dhiraj Khattar, Sanjoy Mullick, Manu Jaggi, Manoj Kumar Singh, Mukesh Kumar, Deepak Prusthy, Pawan Kumar Gupta, Rajendran Praveen, Shobhit Singh
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Patent number: 8338562Abstract: The invention relates to a biocompatible, non-biodegradable, and non-toxic polymer of formula (I), comprising of three monomeric units, selected from 1-Vinylpyrrolidone (VP), N-Isopropylacrylamide (NIPAM), and ester of Maleic anhydride and Polyethylene glycol (MPEG), cross-linked with a bi-functional vinyl derivative, of high purity and substantially free of respective toxic monomeric contaminants, and a process for preparation thereof. The invention further relates to nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds comprising the polymer of the invention, which are safe, less-toxic and convenient for bedside administration to patients in need thereof. Furthermore, the invention relates to a highly selective method for preparation of nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds.Type: GrantFiled: December 26, 2006Date of Patent: December 25, 2012Assignee: Fresenius Kabi Oncology LimitedInventors: Anand C. Burman, Rama Mukherjee, Dhiraj Khattar, Sanjoy Mullick, Manu Jaggi, Manoj Kumar Singh, Mukesh Kumar, Deepak Prusthy, Pawan Kumar Gupta, Rajendran Praveen, Shobhit Singh
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Patent number: 8278483Abstract: The present invention provides processes for the synthesis of novel Shikimic acid head-group containing non-toxic cationic amphiphiles capable of facilitating transport of biological macromolecules into cells.Type: GrantFiled: February 7, 2007Date of Patent: October 2, 2012Assignee: Council of Scientific & Industrial ResearchInventors: Yenugonda Venkata Mahidhar, Arabinda Chaudhuri, Rama Mukherjee
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Patent number: 8022055Abstract: The invention relates to novel betulinic acid derivatives of formula (I), wherein R is C(?CH2)CH3 or CH(CH3)2; R2 together with the adjacent carbonyl group forms a carboxylic acid, carboxylic acid ester or amide or substituted amide; R3 or R4 are hydrogen or aryl with the proviso that both are not independently hydrogen or alkyl or R3 and R4 are combined together to form an aryl ring optionally substituted with a group X, wherein X is selected from halogen, alkyl, cyano, nitro, alkoxy, amino or substituted amine; Y is N or O; and R1 is zero when Y is O, and R1 is hydrogen, alkyl or aryl alkyl when Y is N, useful for inhibition of tumor cancer cells.Type: GrantFiled: December 29, 2005Date of Patent: September 20, 2011Assignee: Dabur Pharma LimitedInventors: Rama Mukherjee, Sanjay Kumar Srivastava, Mohammad Jamshed Ahmed Siddiqui, Manu Jaggi, Anu T. Singh, Anand Vardhan, Manoj Kumar Singh, Praveen Rajendran, Hemant Kumar Jajoo, Anand C. Burman, Vivek Kumar, Nidhi Rani, Shiv Kumar Agarwal
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Publication number: 20100222416Abstract: The present invention, in general, relates to use of nm23H1-B gene for diagnosing cancer susceptibility and metastatic progression in colon/colorectal cancer. In particular, the present invention relates to identifying the alteration in the expression of nm23H1-B gene on treatment with chemotherapeutic agents for diagnosing cancer susceptibility and metastatic progression in colon/colorectal cancer.Type: ApplicationFiled: October 6, 2006Publication date: September 2, 2010Inventors: Kapil Maithal, Harish Chandra, Rama Mukherjee
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Patent number: 7781398Abstract: The present invention relates to a combination of peptides that may be used for treatment of cancer. The peptide combination competes for the binding of specific neuropeptides at the plasma membrane and thereby alters the levels of key intracellular molecules implicated in cell proliferation, resulting in a broad spectrum of anticancer activity. The invention also relates to pharmaceutical compositions containing a combination of such peptide analogs.Type: GrantFiled: December 21, 2006Date of Patent: August 24, 2010Assignee: Dabur Pharma Ltd.Inventors: Rama Mukherjee, Anand C. Burman, Anu T. Singh, Manu Jaggi, Sudhanand Prasad, Sarjana Dutt
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Publication number: 20100184651Abstract: The invention relates to fusion proteins useful as therapeutics against cancer. The fusion protein comprises of cell-targeting moiety and apoptosis-inducing moiety. Cell-targeting moiety and apoptosis-inducing moiety are linked by a flexible linker, which are specifically recognized by cancer specific protease and cleaved in situ to release the apoptotic domain. In particular, the invention is illustrated by a recombinant fusion protein between human Vasoactive Intestinal Peptide (VIP) and BH3 domain of Bcl2 family protein, linked by a linker that has site for cancer specific proteases. The fusion protein specifically targets VIP receptor over-expressing cancer cells and induces cell-specific apoptosis after cleavage at the linker site by cancer specific proteases. Such fusion proteins are useful for the delivery of therapeutic/apoptotic moiety (peptides) to specific cells with perturbed expression of, but not limited to neuropeptide receptors.Type: ApplicationFiled: November 16, 2006Publication date: July 22, 2010Applicant: Dabur Pharma LimitedInventors: Kapil Maithal, Dhatchana Moorthy Nachiappan, Rama Mukherjee
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Patent number: 7699987Abstract: A stabilized pharmaceutical composition of anticancer drug and a solvent like Polyethoxylated castor oil (cremophor) also containing any other suitable solubilizer suitable for human administration like dehydrated alcohol, is disclosed. Compositions prepared using this purified polyethoxylated castor oil enhance the stability of paclitaxel in such compositions.Type: GrantFiled: June 8, 2006Date of Patent: April 20, 2010Assignee: Dabur Pharma Ltd.Inventors: Anand C. Burman, Rama Mukherjee, Dinesh Kumar, Dhiraj Khattar, Mukesh Kumar, Praveen Khullar, Perundurai S. Srinivasan, Rajesh Srivastava
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Publication number: 20090318661Abstract: The invention relates to a biocompatible, non-biodegradable, and non-toxic polymer of formula (I), comprising of three monomeric units, selected from 1-Vinylpyrrolidone (VP), N-Isopropylacrylamide (NIPAM), and ester of Maleic anhydride and Polyethylene glycol (MPEG), cross-linked with a bi-functional vinyl derivative, of high purity and substantially free of respective toxic monomeric contaminants, and a process for preparation thereof. The invention further relates to nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds comprising the polymer of the invention, which are safe, less-toxic and convenient for bedside administration to patients in need thereof. Furthermore, the invention relates to a highly selective method for preparation of nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds.Type: ApplicationFiled: December 26, 2006Publication date: December 24, 2009Applicant: Dabur Pharma LimitedInventors: Anand C. Burman, Rama Mukherjee, Dhiraj Khattar, Sanjoy Mullick, Manu Jaggi, Manoj Kumar Singh, Mukesh Kumar, Deepak Prusthy, Pawan Kumar Gupta, Rajendran Praveen, Shobhit Singh
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Publication number: 20090306213Abstract: The present invention provides processes for the synthesis of novel Shikimic acid head-group containing non-toxic cationic amphiphiles capable of facilitating transport of biological macromolecules into cells.Type: ApplicationFiled: February 7, 2007Publication date: December 10, 2009Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCHInventors: Yenugonda Venkata Mahidhar, Arabinda Chaudhuri, Rama Mukherjee
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Publication number: 20090221682Abstract: The invention relates to a fusion gene useful as a therapeutic and prophylactic vaccine against cancer. The fusion gene contains a DNA encoding ubiquitin gene fused to a second DNA encoding growth factor receptors or fragment thereof, over expressed in various types of cancer. In particular, the invention is illustrated by a recombinant fusion gene comprised of mutated ubiquitin gene and modified extra cellular domain of vasoactive intestinal peptide/pituitary adenylate cyclase activating polypeptide receptor-1 (VPAC1). Immunization with the vaccine will break the self-tolerance for the tumor antigen through effective antigen processing and presentation, leading to retardation/regression of tumor growth.Type: ApplicationFiled: December 19, 2006Publication date: September 3, 2009Inventors: Kapil Maithal, Paromita Sengupta, Rama Mukherjee
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Publication number: 20090017105Abstract: Concentrates or proliposomal compositions of poorly water-soluble drugs and compounds, comprising of one or more membrane forming lipids, a membrane stabilizing agent, in a suitable vehicle, and optionally containing a Polyethylene Glycol (PEG)-coupled phospholipid or a mixture thereof and further, optionally containing pharmaceutically acceptable excipients such as antioxidants, buffering agents, acidifying agents etc. are provided, which have superior long term stability. The concentrates of proliposomal compositions instantly form liposomes of the said poorly water-soluble drugs and compounds on rapid injection to a diluting fluid, the liposomal composition so obtained, characterized by a physical stability more than 24 hours, ?95% drug encapsulation and having a particle size diameter of less than 100 nm. The liposomal compositions so obtained can further be directly administered to patients in need of treatment of the poorly water-soluble drugs and compounds.Type: ApplicationFiled: March 11, 2008Publication date: January 15, 2009Inventors: Dhiraj Khattar, Mukesh Kumar, Rama Mukherjee, Anand C. Burman, Minakshi Garg, Manu Jaggi, Anu T. Singh, Anshumali Awasthi
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Publication number: 20080293682Abstract: The invention relates to novel betulinic acid derivatives of formula (I), wherein R is C(?CH2) CH3 or CH(CH3)2; R2 together with the adjacent carbonyl group forms a carboxylic acid, carboxylic acid ester or amide or substituted amide; R3 or R4 are hydrogen or aryl with the proviso that both are not independently hydrogen or alkyl or R3 and R4 are combined together to form an aryl ring optionally substituted with a group X, wherein X is selected from halogen, alkyl, cyano, nitro, alkoxy, amino or substituted amine; Y is N or O; and R1 is zero when Y is O, and R1 is hydrogen, alkyl or aryl alkyl when Y is N, useful for inhibition of tumor cancer cells.Type: ApplicationFiled: December 29, 2005Publication date: November 27, 2008Inventors: Rama Mukherjee, Kumar Srivastava, Mohammad Jamshed Ahmed Siddioui, Manu Jaggi, Anu T. Singh, Anand Vardhan, Manoj Kumar Singh, Praveen Rajendran, Hemant Kumar Jajoo, Anand C. Burman, Vivek Kumar, Nidhi Rani, Shiv Kumar Agarwal
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Publication number: 20070203248Abstract: The invention relates to pharmaceutical compositions comprising 5-Methoxytryptamine or a salt thereof for the prevention and/or treatment of mammalian cardiac tissue damage. 5-Methoxytryptamine and the salts thereof act as free radical scavengers in the prevention and/or treatment of mammalian cardiac tissue damage mediated by free oxygen radicals.Type: ApplicationFiled: April 26, 2007Publication date: August 30, 2007Inventors: Rama Mukherjee, Anu Singh, Kakali Dutta, G.C. Maickap, Anil Shukla, Dhiraj Khattar, Anand Burman
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Publication number: 20070093422Abstract: The present invention relates to a combination of peptides that may be used for treatment of cancer. The peptide combination competes for the binding of specific neuropeptides at the plasma membrane and thereby alters the levels of key intracellular molecules implicated in cell proliferation, resulting in a broad spectrum of anticancer activity. The invention also relates to pharmaceutical compositions containing a combination of such peptide analogs.Type: ApplicationFiled: December 21, 2006Publication date: April 26, 2007Applicant: DABUR RESEARCH FOUNDATIONInventors: Rama Mukherjee, Anand Burman, Anu Singh, Manu Jaggi, Sudhanand Prasad, Sarjana Dutt
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Patent number: 7179937Abstract: The invention relates to the use of derivatives of cyclopentenone for the inhibition or prevention of the growth or multiplication of cancer cells, and to therapeutic compositions containing such compounds. The invention relates more specifically to the use of derivatives of cyclopentenone for the inhibition and/or prevention of cancer of the colon, pancreas, larynx, ovary, duodenum, kidney, oral cavity, prostate, lung, endothelial cells and leukemias.Type: GrantFiled: December 4, 2002Date of Patent: February 20, 2007Assignee: Dabur Research FoundationInventors: Mukund K. Gurjar, Radhika D. Wakharkar, Gautam R. Desiraju, Ashwini Nangia, Jhillu Singh Yadav, Anand C. Burman, Rama Mukherjee, Hanumant Bapu Rao Borate, Srivari Chandrasekhar, Manu Jaggi, Anuo T. Singh, Kamal Kapoor, Sanjay Sarkhel, K. V. V. M. Sairam
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Patent number: 7173006Abstract: The present invention relates to a combination of peptides that may be used for treatment of cancer. The peptide combination competes for the binding of specific neuropeptides at the plasma membrane and thereby alters the levels of key intracellular molecules implicated in cell proliferation, resulting in a broad spectrum of anticancer activity. The invention also relates to pharmaceutical compositions containing a combination of such peptide analogs.Type: GrantFiled: December 23, 2002Date of Patent: February 6, 2007Assignee: Dabur Research FoundationInventors: Rama Mukherjee, Anand C. Burman, Anu T. Singh, Manu Jaggi, Sudhanand Prasad, Sarjana Dutt
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Publication number: 20060226076Abstract: A stabilized pharmaceutical composition of anticancer drug and a solvent like Polyethoxylated castor oil (cremophor) also containing any other suitable solubilizer suitable for human administration like dehydrated alcohol, is disclosed. Compositions prepared using this purified polyethoxylated castor oil enhance the stability of paclitaxel in such compositions.Type: ApplicationFiled: June 8, 2006Publication date: October 12, 2006Inventors: Anand Burman, Rama Mukherjee, Dinesh Kumar, Dhiraj Khattar, Mukesh Kumar, Praveen Khullar, Perundurai Srinivasan, Rajesh Srivastava
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Publication number: 20060217350Abstract: A stable pharmaceutical composition comprising a solution of disodium pamidronate in an aqueous solvent and a process for the preparation thereof. The solution of disodium pamidronate is free of particulate matter and has an alkaline pH. The process for preparation of the stable pharmaceutical composition comprises adding disodium pamidronate and optionally a sugar into an aqueous solvent; heating the said mixture at a temperature in the range of 50° C. to 90° C. to obtain a clear solution. It is cooled to ambient temperature, filtered, filled and stored in a conventional and untreated glass container and sealed with normal elastomeric closure. The sealed container is sterilized by steam sterilization.Type: ApplicationFiled: October 6, 2005Publication date: September 28, 2006Applicant: DABUR PHARMA LTD.Inventors: Dhiraj Khattar, Manish Grover, Mukesh Kumar, Prasanna Kumar Srinivasa Jonnala, Shobhit Singh, Rama Mukherjee, Anand Burman