Patents by Inventor Ramakrishna Mukkamala
Ramakrishna Mukkamala has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10136823Abstract: A method is provided for determining blood pressure for a subject using a sphygmomanometer. The method includes: measuring an oscillometric cuff pressure waveform of the subject using the sphygmomanometer; representing the measured waveform with a physical model accounting for mechanics of the cuff, an artery and coupling between the cuff and the artery; determining the model unknowns from the measured waveform; and determining blood pressure for the subject using the determined model.Type: GrantFiled: August 28, 2013Date of Patent: November 27, 2018Assignee: Board of Trustees of Michigan State UniversityInventors: Ramakrishna Mukkamala, Jiankun Liu, Jin-Oh Hahn
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Publication number: 20180303351Abstract: A system includes an imaging device that captures multichannel image data from a region of interest on a patient, one or more processors, and memory storing instructions. The memory storing instructions cause the one or more processors to receive the multichannel image data from the imaging device, such that the multichannel image data includes an image signal representative of plethysmographic waveform data for the region of interest and specular noise in the multichannel image data. Furthermore, the memory storing instructions cause the one or more processors to generate a projection matrix associated with the multichannel image data and iterate values of the projection matrix to remove the specular noise to generate a representative physiological signal, such that the representative physiological signal has an improved signal-to-noise ratio relative to the image signal and the representative physiological signal is a representative plethysmographic waveform.Type: ApplicationFiled: April 20, 2017Publication date: October 25, 2018Inventors: Lalit Keshav Mestha, Gayathri Seenumani, Pengfei Meng, Ramakrishna Mukkamala
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Publication number: 20180289288Abstract: A method and apparatus for monitoring arterial properties, including systolic and diastolic pressure levels, of a subject is provided, in which a hardware processor receives and analyzes ballistocardiogram (BCG) data of the subject. A non-transient computer readable medium, accessible by the hardware processor, contains instructions that, when executed by the hardware processor, identify features of the BCG waveform and determine the arterial properties therefrom. For example, a diastolic pressure level may be determined from a time interval between the ‘I’ and ‘J’ peaks of the waveform and a systolic pressure level determined from the amplitude difference between the ‘J’ and ‘K’ peaks of the waveform in combination with the ‘I-J’ time interval or amplitude difference. A physical mechanism for the BCG data is disclosed that enables other arterial properties of the subject to be determined from the BCG data alone or from the BCG data in combination with other measurements.Type: ApplicationFiled: April 6, 2018Publication date: October 11, 2018Applicants: UNIVERSITY OF MARYLAND AT COLLEGE PARK, BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITYInventors: Chang-Sei KIM, Stephanie OBER, Jin-Oh HAHN, Ramakrishna Mukkamala, Omer T. INAN
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Publication number: 20180256045Abstract: Most automatic cuff blood pressure (BP) measurement devices are based on oscillometry. These devices estimate BP from the envelopes of the cuff pressure oscillations using fixed ratios. The values of the fixed ratios represent population averages, so the devices may be accurate only in subjects with normal BP levels. A patient-specific oscillometric BP measurement method was developed. The idea was to represent the cuff pressure oscillation envelopes with a physiologic model and then estimate the patient-specific parameters of the model, which includes BP levels, by optimally fitting it to the envelopes.Type: ApplicationFiled: September 9, 2016Publication date: September 13, 2018Applicants: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY, UNIVERSITY OF MARYLANDInventors: Jiankun LIU, Mohsen MOSLEHPOUR, Jin-Oh HAHN, Ramakrishna MUKKAMALA
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Patent number: 10052070Abstract: A method is provided for determining a central aortic pressure waveform. The method includes: measuring two or more peripheral artery pressure waveforms; analyzing the signals so as to extract common features in the measured waveforms; and determining an absolute central aortic pressure waveform based on the common features.Type: GrantFiled: November 19, 2012Date of Patent: August 21, 2018Assignee: Board of Trustees of Michigan State UniversityInventors: Ramakrishna Mukkamala, Gokul Swamy, Qi Ling, Tongtong Li
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Patent number: 9289133Abstract: The present invention provides methods and apparatus for determining a dynamical property of the systemic or pulmonary arterial tree using long time scale information, i.e., information obtained from measurements over time scales greater than a single cardiac cycle. In one aspect, the invention provides a method and apparatus for monitoring cardiac output (CO) from a single blood pressure signal measurement obtained at any site in the systemic or pulmonary arterial tree or from any related measurement including, for example, fingertip photoplethysmography. According to the method the time constant of the arterial tree, defined to be the product of the total peripheral resistance (TPR) and the nearly constant arterial compliance, is determined by analyzing the long time scale variations (greater than a single cardiac cycle) in any of these blood pressure signals.Type: GrantFiled: October 13, 2010Date of Patent: March 22, 2016Inventors: Richard J. Cohen, Ramakrishna Mukkamala, Derin A. Sherman
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Publication number: 20140066788Abstract: A method is provided for determining pulse transit time of a subject as a function of blood pressure. The method includes: measuring a proximal waveform indicative of the arterial pulse at a proximal site of the subject; measuring a distal waveform indicative of the arterial pulse at a distal site of the subject; defining a relationship between the proximal waveform and the distal waveform in terms of unknown parameters of a nonlinear model; determining the unknown parameters of the nonlinear model from the measured proximal waveform and the measured distal waveform; and determining pulse transit time for the subject as a function of blood pressure from the parameters of the nonlinear model. The nonlinear model can account for arterial compliance and peripheral wave reflection, where the arterial compliance depends on blood pressure.Type: ApplicationFiled: August 27, 2013Publication date: March 6, 2014Applicant: Board of Trustees of Michigan State UniversityInventors: Ramakrishna Mukkamala, Mingwu Gao
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Publication number: 20140066793Abstract: A method is provided for determining blood pressure for a subject using a sphygmomanometer. The method includes: measuring an oscillometric cuff pressure waveform of the subject using the sphygmomanometer; representing the measured waveform with a physical model accounting for mechanics of the cuff, an artery and coupling between the cuff and the artery; determining the model unknowns from the measured waveform; and determining blood pressure for the subject using the determined model.Type: ApplicationFiled: August 28, 2013Publication date: March 6, 2014Applicant: Board of Trustees of Michigan State UniversityInventors: Ramakrishna Mukkamala, Jiankun Liu, Jin-Oh Hahn
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Publication number: 20130184595Abstract: Methods are presented for determining pulse transit time (PTT) and/or pulse wave velocity (PWV) of a subject by application of parametric system identification to proximal and distal arterial waveforms. The two waveforms are measured from the subject. A system is defined that relates the proximal arterial waveform to the distal arterial waveform (or vice versa) in terms of the unknown parameters of a parametric mathematical model. The model parameters are determined from the measured waveforms using system identification. PTT between the proximal and distal arterial sites is then determined from the system model. PWV may also be determined by dividing the distance between measurement sites (D) by PTT.Type: ApplicationFiled: August 12, 2011Publication date: July 18, 2013Applicant: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITYInventors: Ramakrishna Mukkamala, Da Xu, Guanqun Zhang, Mingwu Gao, Mohsen Moslehpour
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Patent number: 8343061Abstract: A method is provided for determining a central aortic pressure waveform. The method includes: measuring two or more peripheral artery pressure waveforms; analyzing the signals so as to extract common features in the measured waveforms; and determining an absolute central aortic pressure waveform based on the common features.Type: GrantFiled: March 15, 2007Date of Patent: January 1, 2013Assignee: Board of Trustees of Michigan State UniversityInventors: Ramakrishna Mukkamala, Gokul Swamy, Qi Ling, Tongtong Li
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Patent number: 8282569Abstract: A method is provided for determining ejection fraction. The method includes: measuring a physiologic signal indicative of blood pressure; analyzing the physiologic signal at more than one time instance so as to extract information present in its temporal variations; and determining ejection fraction based in part on the extracted information.Type: GrantFiled: March 15, 2007Date of Patent: October 9, 2012Assignee: Board of Trustees of Michigan State UniversityInventor: Ramakrishna Mukkamala
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Patent number: 8273031Abstract: Method and apparatus are introduced for determining proportional cardiac output (CO), absolute left atrial pressure (LAP), and/or other important hemodynamic variables from a contour of a circulatory pressure waveform or related signal. Certain embodiments of the invention provided herein include the mathematical analysis of a pulmonary artery pressure (PAP) waveform or a right ventricular pressure (RVP) waveform in order to determine beat-to-beat or time-averaged proportional CO, proportional pulmonary vascular resistance (PVR), and/or LAP. The invention permits continuous and automatic monitoring of critical hemodynamic variables with a level of invasiveness suitable for routine clinical application. The invention may be utilized, for example, to continuously monitor critically ill patients with pulmonary artery catheters installed and chronically monitor heart failure patients instrumented with implanted devices for measuring RVP.Type: GrantFiled: December 23, 2009Date of Patent: September 25, 2012Assignees: Board of Trustees Operating Michigan State University, Massachusetts Institute Of TechnologyInventors: Richard Cohen, Ramakrishna Mukkamala
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Publication number: 20110263989Abstract: A method is provided for determining a central aortic pressure (AP) wave-form for a subject. The method includes measuring a peripheral artery pressure (PAP) waveform from the subject, employing a distributed model to define a pressure-to-pressure transfer function relating PAP to AP and a pressure-to-flow transfer function relating PAP to a central arterial flow in terms of the same unknown parameters, estimating the unknown parameters by finding the pressure-to-flow transfer function, which when applied to the measured PAP waveform, minimizes the magnitude of the central arterial flow waveform during diastole, and applying the pressure-to-pressure transfer function with the estimated parameters to determine an AP waveform for the subject.Type: ApplicationFiled: May 27, 2009Publication date: October 27, 2011Inventors: Ramakrishna Mukkamala, Gokul Swamy, Nicholas Bari Olivier
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Publication number: 20110034813Abstract: The present invention provides methods and apparatus for determining a dynamical property of the systemic or pulmonary arterial tree using long time scale information, i.e., information obtained from measurements over time scales greater than a single cardiac cycle. In one aspect, the invention provides a method and apparatus for monitoring cardiac output (CO) from a single blood pressure signal measurement obtained at any site in the systemic or pulmonary arterial tree or from any related measurement including, for example, fingertip photoplethysmography. According to the method the time constant of the arterial tree, defined to be the product of the total peripheral resistance (TPR) and the nearly constant arterial compliance, is determined by analyzing the long time scale variations (greater than a single cardiac cycle) in any of these blood pressure signals.Type: ApplicationFiled: October 13, 2010Publication date: February 10, 2011Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITYInventors: Richard J. Cohen, Ramakrishna Mukkamala, Derin A. Sherman
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Patent number: 7815578Abstract: The present invention provides methods and apparatus for determining a dynamical property of the systemic or pulmonary arterial tree using long time scale information, i.e., information obtained from measurements over time scales greater than a single cardiac cycle. In one aspect, the invention provides a method and apparatus for monitoring cardiac output (CO) from a single blood pressure signal measurement obtained at any site in the systemic or pulmonary arterial tree or from any related measurement including, for example, fingertip photoplethysmography. According to the method the time constant of the arterial tree, defined to be the product of the total peripheral resistance (TPR) and the nearly constant arterial compliance, is determined by analyzing the long time scale variations (greater than a single cardiac cycle) in any of these blood pressure signals.Type: GrantFiled: September 22, 2003Date of Patent: October 19, 2010Assignees: Massachusetts Institute of Technology, Board of Trustees of Michigan State UniversityInventors: Richard J. Cohen, Ramakrishna Mukkamala, Derin A. Sherman
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Publication number: 20100099993Abstract: Method and apparatus are introduced for determining proportional cardiac output (CO), absolute left atrial pressure (LAP), and/or other important hemodynamic variables from a contour of a circulatory pressure waveform or related signal. Certain embodiments of the invention provided herein include the mathematical analysis of a pulmonary artery pressure (PAP) waveform or a right ventricular pressure (RVP) waveform in order to determine beat-to-beat or time-averaged proportional CO, proportional pulmonary vascular resistance (PVR), and/or LAP. The invention permits continuous and automatic monitoring of critical hemodynamic variables with a level of invasiveness suitable for routine clinical application. The invention may be utilized, for example, to continuously monitor critically ill patients with pulmonary artery catheters installed and chronically monitor heart failure patients instrumented with implanted devices for measuring RVP.Type: ApplicationFiled: December 23, 2009Publication date: April 22, 2010Inventors: Richard J. COHEN, Ramakrishna Mukkamala
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Patent number: 7666144Abstract: Method and apparatus are introduced for determining proportional cardiac output (CO), absolute left atrial pressure (LAP), and/or other important hemodynamic variables from a contour of a circulatory pressure waveform or related signal. Certain embodiments of the invention provided herein include the mathematical analysis of a pulmonary artery pressure (PAP) waveform or a right ventricular pressure (RVP) waveform in order to determine beat-to-beat or time-averaged proportional CO, proportional pulmonary vascular resistance (PVR), and/or LAP. The invention permits continuous and automatic monitoring of critical hemodynamic variables with a level of invasiveness suitable for routine clinical application. The invention may be utilized, for example, to continuously monitor critically ill patients with pulmonary artery catheters installed and chronically monitor heart failure patients instrumented with implanted devices for measuring RVP.Type: GrantFiled: February 21, 2006Date of Patent: February 23, 2010Assignees: Board of Trustees Operating Michigan State University, Massachusetts Institute of TechnologyInventors: Richard J. Cohen, Ramakrishna Mukkamala
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Publication number: 20090131804Abstract: A method is provided for determining a central aortic pressure waveform. The method includes: measuring two or more peripheral artery pressure waveforms; analyzing the signals so as to extract common features in the measured waveforms; and determining an absolute central aortic pressure waveform based on the common features.Type: ApplicationFiled: March 15, 2007Publication date: May 21, 2009Inventors: Ramakrishna Mukkamala, Gokul Swamy, Qi Ling, Tongtong Li
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Publication number: 20090112113Abstract: A method is provided for determining ejection fraction.Type: ApplicationFiled: March 15, 2007Publication date: April 30, 2009Applicant: Board of Trustees of Michigan State UniversityInventor: Ramakrishna Mukkamala
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Publication number: 20070197921Abstract: Method and apparatus are introduced for determining proportional cardiac output (CO), absolute left atrial pressure (LAP), and/or other important hemodynamic variables from a contour of a circulatory pressure waveform or related signal. Certain embodiments of the invention provided herein include the mathematical analysis of a pulmonary artery pressure (PAP) waveform or a right ventricular pressure (RVP) waveform in order to determine beat-to-beat or time-averaged proportional CO, proportional pulmonary vascular resistance (PVR), and/or LAP. The invention permits continuous and automatic monitoring of critical hemodynamic variables with a level of invasiveness suitable for routine clinical application. The invention may be utilized, for example, to continuously monitor critically ill patients with pulmonary artery catheters installed and chronically monitor heart failure patients instrumented with implanted devices for measuring RVP.Type: ApplicationFiled: February 21, 2006Publication date: August 23, 2007Inventors: Richard J. Cohen, Ramakrishna Mukkamala